Matteo Siciliano’s Post

One Man Journal Club : Day 17 Adaptive Deep Brain Stimulation(DBS) This study tested a dual algorithm for adaptive DBS to account for sleep effects on biomarkers in Parkinson's patients. 4 Parkinson's patients had electrodes implanted in subcortical and cortical areas. One detector used cortical alpha and theta power to track sleep state with a single threshold. Another detector tracked Parkinsonian motor signs using subcortical biomarkers relative to two thresholds. Detector parameters were optimized using patient training data across wake/sleep and medication cycles. Performance was tested using algorithm state logs downloaded daily from patients at home over 47 days. The sleep detector achieved high concordance (mean 88%) with patient reported sleep state. It successfully switched to sleep mode during sleep across 47 days of testing. The motor sign detector adjusted stimulation based on medication fluctuations when patients were awake. Discriminating sleep is crucial for chronic embedded adaptive DBS, as biomarkers are influenced by sleep. This study demonstrates a crucial development in the field of adaptive deep brain stimulation for neurological and psychiatric indications. The dual detector design elegantly overcomes this issue by allowing independent tracking of sleep and disease states on different timescales appropriate for each. Enabling adaptive DBS systems to respond intelligently to sleep could improve outcomes and quality of life for patients. #neurosurgery #deepbrainstimulation #adaptivelearning #parkinsons #mentalhealth

Shown by us 10 years ago .. Upregulation of Chaperone proteins and consequent removal of beta amyloid in AD mice by 1072nm https://lnkd.in/exyc-cdq

THE BRAIN-DRAIN I Was encouraged to see the published studies over the past year, to attest to PBMs ability to increase lymphatics of the brain. We have seen many studies to show it’s advantages in neurological health and cognition. I have long promoted the real benefits of thorough lymph drainage and vagus work, and so too to promote the enormous benefits of ACCURATE PBM (it biphasic so accuracy is crucial). To be able to trust a therapy like PBM, that has so many benefits, to increase cleansing and detoxification of the brain is a game changer in wellness. Our specialised and unique protocols of care put PBM as a pivotal element of every facility we install. To us, PBM is as important to humans as Oxygen itself: You need both to trigger ATP (PBM being the right light). However, knowing when, how, why, in what order to use it and to incorporate it into a real care plan, is what makes all the difference and delivers accelerated results and outcomes for ultimate, reliable effects. #glymphatics #lymph #mentalhealth #PBM #integratedtherapy #wellness #ATP #alzheimers #dementia #braindrain #betaamyloid

Shown by us 10 years ago .. Upregulation of Chaperone proteins and consequent removal of beta amyloid in AD mice by 1072nm https://lnkd.in/exyc-cdq

Interesting article from Aaron Dorman on the use of light therapy as a "washing machine" to increase the removal of beta-amyloid during sleep. It is said that this Beta-amyloid build-up is what causes Alzheimer's. 🧠 "The use of a specific kind of low-level infrared light therapy labeled photobiomodulation technology — PBM, for short — successfully stimulated faster removal of beta-amyloid in mice with Alzheimer’s, a recent study showed, a “very promising” result for future, human therapies." #lighttherapy #alzheimers #neuroscience Read more here 🔗 https://lnkd.in/dyegHQGq

"I will give you this sedative, and you will sleep like a baby... 🛌😴👶" 💤 Sedatives are often used to induce sleep in patients, but did you know they don't produce any patterns resembling natural sleep? The patient may be "unconscious," but they're not truly "sleeping." 🛏️ Using AI 🤖 and EEG brain 🧠waveforms, we demonstrate that sedatives like propofol and sevoflurane do not mimic natural sleep, while dexmedetomidine produces sleep-like patterns to some extent. The proposed AI framework can also be used in clinical trials to test sleep-promoting drugs in real-time, instead of waiting months for the analysis. 🎉Congratulations to the amazing team (Michel Struys Sowmya Ramaswamy, PhD Hugo Vereecke Merel Kuizenga Maud Weerink)for this outstanding multidisciplinary achievement, combining AI, anaesthesiology, neurology, and sleep research!👏🧠💡 #AI #Sleep #Anesthesiology #EEG #Neurology #SleepMedicine #MachineLearning https://lnkd.in/gMCPgZP3

🧠 Exciting Breakthrough in Consciousness Research! 🌟 A new study has unveiled an innovative technique that allows anesthesiologists to track changes in consciousness. This breakthrough not only enhances medical procedures like surgery but also deepens our understanding of the human mind, especially in states of sleep, coma, and anesthesia. Can we tap into this for learning and training? Christian S. Guay, M.D. | Massachusetts General Hospital | Harvard Medical School | Massachusetts Institute of Technology | Emery N. Brown | Scientific American | Neuroscience News | Medical Research Council | Anesthesiology News | American Anesthesiology | ScienceDaily | Cognitive Science | Psychology Today | Daisy Yuhas #ConsciousnessStudies #BrainResearch #AnestheticAdvances #NeuralScience #MedicalInnovations #SurgicalCare #PatientSafety #EEGResearch #MindfulMedicine #HealthcareTechnology #CognitiveFunction #SleepStudies #ComaResearch #NeurologicalAdvancements #MindBodyConnection #SedationScience #ClinicalNeuroscience #BrainFunction #MindConsciousness #NeurologyBreakthroughs

Our extensive critical and narrative review on the enigma of sleep-related paroxysmal motor episodes (SPMEs) is now online in Epilepsia. We have reviewed all the original articles from 1970s starting with the original descriptions of pavor nocturnus, nocturnal paroxysmal dystonia to the newer terms of nocturnal frontal lobe epilepsy and sleep-related hypermotor epilepsy. This is not a homogenous clinical syndrome and clinicians must refrain from assuming that all SPMEs are epileptic in nature. This is a heterogenous syndrome with likely varying underlying causes, including non-epileptic like parasomnias. #Epilepsy #EEG #Seizure #Neurophysiology #Neurology https://lnkd.in/dCMx76ws

During the 2024 American Academy of Neurology Annual Meeting, Eisai US unveiled groundbreaking research on DAYVIGO (lemborexant), demonstrating its effectiveness in addressing insomnia-related concerns. Two highlighted posters showcased significant findings: one emphasized the enhancement of morning alertness in individuals with insomnia disorder, indicating notable increases in alertness ratings and a higher proportion of subjects transitioning towards alertness post-treatment with DAYVIGO compared to placebo. The other poster outlined the response and remission rates of DAYVIGO in older adults with insomnia and objective short sleep, revealing substantial enhancements in sleep outcomes. Explore more about recent advancements in the Insomnia market: https://lnkd.in/gTkV9szz #AAN2024 #EisaiInc #DAYVIGO #Lemborexant #InsomniaTreatment #NeurologyConference

📢 Review Paper Sharing-Vol. 22 No. 5 💕 Title: Derailment of Sleep Homeostatic Plasticity Affects the Most Plastic Brain Systems and Carries the Risk of Epilepsy 🤵 Authors: Peter Halász*, Igor Timofeev, Anna Szűcs 🔔 Full Text: https://lnkd.in/guY-c88D 🔑 Keywords: sleep homeostatic plasticity epileptic derailment of functional brain networks system epilepsy 😎Welcome to your reading! #Parkinsons #ParkinsonsDisease #Neurology #BrainHealth #MovementDisorders #Dopamine #NeurodegenerativeDiseases #Healthcare #Research #Awareness #Treatment #SupportGroups #PatientCare #Therapeutics #MentalHealth #Neuroscience #CureParkinsons #BrainMapping #Neurobiology #BrainInjury #NeuroscienceNews #NeuroImaging