Maurice Kumalo’s Post

Discover this Q&A, where Thomas Kipping, Ph.D., Head of 3D Printing and Solubility Enhancement, sheds light on the evolution, current state, and future prospects of #3Dprinting in pharma, in conversation with Pharma‘s Almanac to discuss the topic of additive manufacturing, commonly known as 3D printing, and how it is reshaping pharmaceutical manufacturing. Unlike traditional oral solid dose (OSD) manufacturing, 3D printing offers unparalleled flexibility in designing drug prototypes, final dosage forms enabling precision dosing and the creation of complex release kinetics. This technology is especially valuable during early R&D, for creating innovative dosage forms and streamlining the supply of clinical trial material. Our raw materials portfolio plays a leading role in the 3D printing space, establishing collaborations and developing products to realize the potential of additive manufacturing. #solidformulation #formulation #osd #drugdevelopment

In this new Q&A on Pharma's Almanac, MilliporeSigma’s Thomas Kipping, sheds light on the evolution, current state, and future prospects of 3D printing in pharma, including applications for creating innovative dosage forms and streamlining the supply of clinical trial material. #pharma #3dprinting #additivemanufacturing #clinicalsupply #osd #pharmaceuticalinnovation

Discover this Q&A, where Thomas Kipping, Ph.D., Head of 3D Printing and Solubility Enhancement, sheds light on the evolution, current state, and future prospects of 3D printing in pharma, in conversation with Pharma’s Almanac's to discuss the topic of additive manufacturing, commonly known as 3D printing, and how it is reshaping pharmaceutical manufacturing. Unlike traditional oral solid dose (OSD) manufacturing, 3D printing offers unparalleled flexibility in designing drug prototypes, final dosage forms enabling precision dosing and the creation of complex release kinetics. This technology is especially valuable during early R&D, for creating innovative dosage forms and streamlining the supply of clinical trial material. Our raw materials portfolio plays a leading role in the 3D printing space, establishing collaborations and developing products to realize the potential of additive manufacturing. #solidformulation #formulation #osd #drugdevelopment

Discover this Q&A, where Thomas Kipping, Ph.D., Head of 3D Printing and Solubility Enhancement, sheds light on the evolution, current state, and future prospects of 3D printing in pharma, in conversation with Pharma’s Almanac's to discuss the topic of additive manufacturing, commonly known as 3D printing, and how it is reshaping pharmaceutical manufacturing. Unlike traditional oral solid dose (OSD) manufacturing, 3D printing offers unparalleled flexibility in designing drug prototypes, final dosage forms enabling precision dosing and the creation of complex release kinetics. This technology is especially valuable during early R&D, for creating innovative dosage forms and streamlining the supply of clinical trial material. Our raw materials portfolio plays a leading role in the 3D printing space, establishing collaborations and developing products to realize the potential of additive manufacturing. #solidformulation #formulation #osd #drugdevelopment

Discover this Q&A, where Thomas Kipping, Ph.D., Head of 3D Printing and Solubility Enhancement, sheds light on the evolution, current state, and future prospects of 3D printing in pharma, in conversation with Pharma’s Almanac's to discuss the topic of additive manufacturing, commonly known as 3D printing, and how it is reshaping pharmaceutical manufacturing. Unlike traditional oral solid dose (OSD) manufacturing, 3D printing offers unparalleled flexibility in designing drug prototypes, final dosage forms enabling precision dosing and the creation of complex release kinetics. This technology is especially valuable during early R&D, for creating innovative dosage forms and streamlining the supply of clinical trial material. Our raw materials portfolio plays a leading role in the 3D printing space, establishing collaborations and developing products to realize the potential of additive manufacturing. #solidformulation #formulation #osd #drugdevelopment

𝗔𝗺𝗼𝗿𝗽𝗵𝗼𝘂𝘀 𝘀𝗼𝗹𝗶𝗱 𝗱𝗶𝘀𝗽𝗲𝗿𝘀𝗶𝗼𝗻 𝗼𝗳 𝗮 𝗯𝗶𝗻𝗮𝗿𝘆 𝗳𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝘄𝗶𝘁𝗵 𝗳𝗲𝗹𝗼𝗱𝗶𝗽𝗶𝗻𝗲 𝗮𝗻𝗱 𝗛𝗣𝗠𝗖 𝗳𝗼𝗿 𝟯𝗗 𝗽𝗿𝗶𝗻𝘁𝗲𝗱 𝗳𝗹𝗼𝗮𝘁𝗶𝗻𝗴 𝘁𝗮𝗯𝗹𝗲𝘁𝘀 This study focuses on the combination of three-dimensional printing (3DP) and amorphous solid dispersion (ASD) technologies for the manufacturing of gastroretentive floating tablets. Employing hot melt extrusion (HME) and fused deposition modeling (FDM), the study investigates the development of drug-loaded filaments and 3D printed (3DP) tablets containing felodipine as model drug and hydroxypropyl methylcellulose (HPMC) as the polymeric carrier. Prior to fabrication, solubility parameter estimation and molecular dynamics simulations were applied to predict drug-polymer interactions, which are crucial for ASD formation. Physical bulk and surface characterization complemented the quality control of both drug-loaded filaments and 3DP tablets. The analysis confirmed a successful amorphous dispersion of felodipine within the polymeric matrix. Furthermore, the low infill percentage and enclosed design of the 3DP tablet allowed for obtaining low-density systems. This structure resulted in buoyancy during the entire drug release process until a complete dissolution of the 3DP tablets (more than 8 h) was attained. The particular design made it possible for a single polymer to achieve a zero-order controlled release of the drug, which is considered the ideal kinetics for a gastroretentive system. Accordingly, this study can be seen as an advancement in ASD formulation for 3DP technology within pharmaceutics. Continue reading here: https://lnkd.in/eBY79sp6 by: Gloria Mora Castaño, Mónica Millán-Jiménez, Andreas Niederquell, Monica Schönenberger, Fatemeh Shojaie, Pharm.D, Martin Kuentz, Isidoro Caraballo #3dprinting #excipients #pharmaceuticals

🌟 Revolutionizing Medication with 3D Printing! 💊✨ 🖨️ Researchers at the University of Nottingham's Centre for Additive Manufacturing and the School of Pharmacy have developed an innovative technique using Multi-Material InkJet 3D Printing (MM-IJ3DP) to fabricate personalized pharmaceutical tablets. This cutting-edge method allows for the printing of multiple drugs in a single tablet, enabling timed doses and personalized medication regimens. 📅🕒 🔬 Key Highlights: Precision Treatment: Custom tablets with tailored drug release profiles for more effective treatment. Innovative Technology: Utilizing a novel ink formulation sensitive to ultraviolet light, creating water-soluble structures within the tablet. Simplified Medication Regimens: Print multiple drugs in a single tablet, simplifying complex medication schedules. Scalability: Ability to print 56 pills in a single batch, demonstrating strong potential for large-scale production. 💬 Dr. Yinfeng He, Assistant Professor in the Faculty of Engineering's Centre for Additive Manufacturing, states, "This is an exciting step forward in the development of personalized medication. This breakthrough not only highlights the potential of 3D printing in revolutionizing drug delivery but also opens up new avenues for next-generation personalized medicines." 📈 While promising, the technology faces challenges, including the need for more formulations to support a wider range of materials. Ongoing research aims to refine these aspects, enhancing the feasibility of MM-IJ3DP for widespread application. 🌍 Professor Felicity Rose from the School of Pharmacy emphasizes, "The future of prescribed medication lies in a personalized approach. A single pill approach would simplify taking multiple medications at different times, and this research is an exciting step towards that." #Pharmaceuticals #3DPrinting #PersonalizedMedicine #HealthcareInnovation #DrugDelivery #MedicalResearch #AdditiveManufacturing #FutureOfMedicine #UniversityOfNottingham #Pharmacy #Innovation #Healthcare

Discover this Q&A, where Thomas Kipping, Ph.D., Head of 3D Printing and Solubility Enhancement, sheds light on the evolution, current state, and future prospects of 3D printing in pharma, in conversation with Pharma’s Almanac's to discuss the topic of additive manufacturing, commonly known as 3D printing, and how it is reshaping pharmaceutical manufacturing. Unlike traditional oral solid dose (OSD) manufacturing, 3D printing offers unparalleled flexibility in designing drug prototypes, final dosage forms enabling precision dosing and the creation of complex release kinetics. This technology is especially valuable during early R&D, for creating innovative dosage forms and streamlining the supply of clinical trial material. Our raw materials portfolio plays a leading role in the 3D printing space, establishing collaborations and developing products to realize the potential of additive manufacturing. #solidformulation #formulation #osd #drugdevelopment

Discover this Q&A, where Thomas Kipping, Ph.D., Head of 3D Printing and Solubility Enhancement, sheds light on the evolution, current state, and future prospects of 3D printing in pharma, in conversation with Pharma’s Almanac's to discuss the topic of additive manufacturing, commonly known as 3D printing, and how it is reshaping pharmaceutical manufacturing. Unlike traditional oral solid dose (OSD) manufacturing, 3D printing offers unparalleled flexibility in designing drug prototypes, final dosage forms enabling precision dosing and the creation of complex release kinetics. This technology is especially valuable during early R&D, for creating innovative dosage forms and streamlining the supply of clinical trial material. Our raw materials portfolio plays a leading role in the 3D printing space, establishing collaborations and developing products to realize the potential of additive manufacturing. #solidformulation #formulation #osd #drugdevelopment

How will 3D printing transform pharmaceutical manufacturing? Have a look at my recent discussion with David Alvaro from Pharma's Almanac. #pharma #manufacturing #additivemanufacturing #3Dprinting