Maurizio Molinari’s Post

NEET - 2014 -15 SOLVED PAPER; ENDOCRINE GLANDS; MOMENT OF INERTIA; RADIUS OF GYRATION; DIESTION #NEETMADEEASYKOTA, #PHYSICSMADEEASYKOTA, #CHEMISTRYMADEEASYKOTA, #BIOLOGYMADEEASYKOTA

Looking at this graphic, one can see why SGLT2is are so powerful in heart failure. It appears that they complement the good things many diuretics bring to the table while improving on those that are drawbacks, such as improving magnesium ans lowering uric acid. One day there will be a great paper that discusses all of the underlying pathophysiologic changes SGLT2is address. Until then, IMHO Dr. Inzucchi’s explanation in the EMPA-REG OUTCOME paper still stands the test of time.

🔔 New issue! Featuring articles on cell differentiation, potassium channels, and more: ✍️ Review: Enzyme-centered approaches for cyclic oligo-nucleotide research ✳️ Editor’s Choice: 3D structure of Tetrahymena Vint domain 🎨 On the cover: Cryo-EM reconstruction of Slo1 channel Read the issue here: bit.ly/49Sofai

Our recent article on Si-based anode and NMC cell with pre-lithiation strategies. An Important and Useful paper for practical cell development.

This week’s #ChemSciPicks is a fantastic Edge article by Maike Lundahl et al. (University of Washington, USA), titled: ‘Exploring the influence of H-bonding and ligand constraints on thiolate ligated non-heme iron mediated dioxygen activation’. In this manuscript, Maike Lundahl et al. quantitatively examine the formation of a well-characterized, reactive, O2-derived thiolate ligated FeIII-superoxo using low-temperature stopped-flow kinetics. The reported kinetic results afford an experimentally determined reaction coordinate that illustrates the influence of H-bonding and ligand constraints on the kinetic barrier to dioxygen activation, an essential step in biosynthetic pathways critical to life. You can read the paper in full and for free here: https://lnkd.in/eQmwUxRz

Acynonapyr, discovered by Nippon Soda Co., Ltd., is a novel acaricide with N-pyridyloxy azabicycle as a unique core structure. The current study determines the activity of acynonapyr and its analogs on calcium-activated potassium (KCa2) channels in two-spotted spider mites using electrophysiological techniques. Comparison of T. urticae acaricidal activity with inhibitory activity against TurKCa2 suggests that the TurKCa2 channels are the primary toxicological targets. And the best part, Acynonapyr was found to exert a limited or no inhibitory effect on Homo sapiens KCa2 channel. https://lnkd.in/gPPcDFrf

ACYNONAPYR, A NEW CLASS OF ACARICIDES CONTAINING AN AZABICYCLO RING Resistance to insecticides and acaricides is a major impediment to effectively controlling insect pests worldwide. These pests include the two-spotted spider mite Tetranychus urticae (T. urticae), which exists globally. This polyphagous herbivore causes major agricultural problems and can develop resistance to the agents above. Acynonapyr is a novel class of acaricides containing an azabicyclo ring. Acynonapyr - and its analogs - are active on calcium-activated potassium (KCa2) channels in two-spotted spider mites using electrophysiological techniques (patch-clamp). The effect of acynonapyr on Homo sapiens KCa2 (HsaKCa2.2) channels are limitated up to 10 μM. #acynopapyr #acaricides

Check out our recent publication on the "beneficial" degradation of photocatalyst and its impact on the halogen-atom-transfer reaction, published in Angewandte Chemie as an accepted article!

Hello! I'm excited to share my first paper from the Davies group, where I am the first author. The paper explores the reactivity of donor-acceptor carbenes towards [2.2]paracyclophanes ([2.2]PCP). Our work involved the Rh(II)-catalyzed regioselective asymmetric cyclopropanation of donor-acceptor carbenes to prepare chiral [2.2]PCP. This was achieved through the kinetic resolution of mono-substituted [2.2]PCP or the desymmetrization of pseudo-para disubstituted [2.2]PCP. Additionally, we demonstrated that this class of chiral [2.2]PCP can be used as a ligand for a new dirhodium tetracarboxylate catalyst, showing good asymmetric induction in cyclopropanation. Lastly, I want to express my deep honor and pride in being a member of the Davies group. Check it our here: https://lnkd.in/erxAuV7Z

Dynamic-to-static chirality: In their new article in @J_A_C_S, Ito, Jin, et al. report a suppression of the solution-state dynamic chirality and stabilization of homochirality with activation of circularly polarized luminescence in the solid-state by crystallization of azahelicene complexes of gold. Read the full article: