MD Biosciences Neuro’s Post

Discover the breakthroughs in translational pig models in our latest whitepaper! Pigs are highly valuable research models due to their remarkable resemblance to human physiology. Pigs offer clinically relevant data, short lead times, and competitive pricing. Download the whitepaper to learn more about pig models for pain, inflammation, and wound healing, as well as successful therapeutic studies using the POP model. https://hubs.la/Q02x4zPl0 #preclinicalresearch #drugdevelopment #translationalresearch #woundhealing #neuroinflammation #neuropathicpain #neurodegeneration

Tucson Biotech Bike Ride #6 took place on Saturday, March 30th with Zachary S. Brooks, PhD, EMBA from UGenome AI and Nicholas King from Critical Path Institute (C-Path). The next Tucson Biotech Bike Ride will take place on Saturday, April 28th starting at 7am. #ThisIsTucson, #techlauncharizona, #ugenomeai, #theracea, #metfora, #bioinformatics , #biotech, #genetics, #science, #medicine, #drugdiscovery, #radiopharmaceuticals, #lifesciences, #health, #pharma, #bloodtesting, #CPath, #CPAD, #CPP, #NSAM, #neuroscience, #globalhealth, #alzheimers, #parkinsons, #drugdevelopment, #datasharing, #collaboration, #clinicaltrials, #FDA, #EMA

Learn how humanized mouse models are revolutionizing drug discovery by effectively replicating human physiology and aiding in predicting responses to immunomodulatory compounds. Use the link below to register for this webinar which is happening on August 14th 11 am ET: https://lnkd.in/gVcZCTsD #humanized #mouse #preclinical #research #drugdevelopment

#callforpapers to the #specialissue in Methods and Protocols MDPI "Feature Papers in Methods and Protocols 2024". 🙌If you have suitable papers, please contact with Eunice Fu (eunice.fu@mdpi.com) Welcome to submit your manuscript here: https://lnkd.in/gHvJVv-G Submission deadline: 31 December 2024 Guest Editor: Prof. Dr. Fernando Albericio from University of KwaZulu-Natal #methods #protocols #lifesciences #chemistry #medical #biomedical #publichealth #biology #openaccess #cells #imaging #nanotechnology #genomics #tissue #physiology #organoids #proteomics #biophysics

🔔 Out now! Our blog post detailing the culture of primary human hepatocytes in both 2D and complex models for the advancement of drug discovery, ADME, toxicity, DDI, and tissue engineering. https://lnkd.in/eHQmdhVF Talk with our experts to discover how to leverage our primary human hepatic cells to empower your sciences: info@mosaiccellsci.com

A Bruker Avance IVDr* spectrometer was used by gastroenterology clinical researchers to demonstrate that a high urine #hippurate concentration is a general marker of metabolic health, and in the context of obesity induced by high-fat diets, hippurate contributes to metabolic improvements, highlighting its potential as a mediator of metabolic health. Read the article: https://lnkd.in/d5mcDBuR Learn more about Bruker Avance IVDr and #NMR* clinical research solutions and applications: https://lnkd.in/dRuWSXXT BMJ *Bruker NMR Instruments are for Research Use Only. Not for Use in Clinical Diagnostic Procedures. #Metabolomics #Urology #Gastroenterology

We had a great time at the 𝗖𝘂𝗿𝗲 𝗖𝗟𝗖𝗡𝟰 𝗦𝗰𝗶𝗲𝗻𝘁𝗶𝗳𝗶𝗰 𝗠𝗲𝗲𝘁𝗶𝗻𝗴, connecting with leading scientists and learning about the latest advancements in CLC transporter research, including functional models in rodents, new approaches using iPSC models, and updated genetic profiling of affected families. Inspired by the discussions, we are excited to share our new flyer highlighting the characterization of ClC-7, ClC-K, and ClC from E. coli using solid-supported membrane (SSM)-based electrophysiology. If you're researching 𝗖𝗹𝗖 𝘁𝗿𝗮𝗻𝘀𝗽𝗼𝗿𝘁𝗲𝗿𝘀, we invite you to try your samples on our SSME platforms, called SURFE2R, free of charge. You will gain insights on: ✅ Transporter activity of ClCs ✅ pH dependence of transport ✅ Ion selectivity ✅ Pharmacology Download our flyer and learn more about ClC electrophysiology here: https://lnkd.in/eiQwxvBv Cure CLCN4 #CureCLCN4 #Research #MembraneTransporters #SURFE2R #Electrophysiology #DrugDiscovery #ClC #SSME

“But mouse models are cheaper”   A frequently heard argument. Not even to start mentioning the lack of translatability to humans and general ethical considerations in line with the need to replace animal testing overall, but what about other species? Non-human primates are still being used for a variety of preclinical safety testing. However, the translatability is more than often faulty again, the experiments are much more expensive & time consuming. So even if you want to put all the ethical considerations aside, there is also a financial impact when relying on non-human primates in testing for more complex drugs such as biopharmaceuticals or LNPs. #drugdiscovery #3Rs #preclinical

Struggling to recreate the human physiology in vitro? 💬 We have interviewed Natalia Sánchez Romero, R&D Director at BeCytes, who has given some insights about the necessity of creating in vitro models that approximate in vivo behavior and BeCytes options to recreate the hepatic microenvironment. BeCytes has developed a cell procuring service that offers liver cells, including both primary hepatocytes and non-parenchymal cells. These cells enable the creation of reliable 3D liver models for research purposes. Our cells are produced under rigorous QC standards and fully characterized, including 3D/spheroid qualification. 🔵 Don't miss it! https://lnkd.in/dvW-Vs2v #livermodels #cellculture #hepaticcells #BeCytesBiotechnologies

Pain hypersensitivity includes molecular mediation of transient receptor potential canonical 5 (TRPC5) channels in rodent and human sensory neurons, suggesting inhibition of TRPC5 to reduce experience of pain.(Science Translational Medicine 5/26/2021)