MedChemExpress LLC’s Post

🌟🌟Oxygen Levels and Angiogenesis: A Delicate Balance 🙌 📌Angiogenesis, the formation of new blood vessels, is a vital process that relies heavily on oxygen levels. When oxygen levels are high, angiogenesis is suppressed, but when oxygen levels drop, angiogenesis is activated. Here's how it works: - High oxygen levels (normoxia): HIF-1α is degraded, preventing the activation of pro-angiogenic genes. - Low oxygen levels (hypoxia): HIF-1α is stabilized, activating pro-angiogenic genes like VEGF, promoting angiogenesis. This balance is crucial in healthy tissues, but cancer cells exploit this mechanism to promote tumor growth and angiogenesis. Understanding this relationship can lead to new therapeutic strategies for cancer treatment. #Angiogenesis #OxygenLevels #HIF1alpha #VEGF #CancerResearch"

"Proline is a nonessential amino acid, and its metabolism has been implicated in numerous malignancies. Together with a direct role in regulating cancer cells’ proliferation and survival, proline metabolism plays active roles in shaping the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) display high rates of proline biosynthesis to support the production of collagen for the extracellular matrix (ECM). Indeed, impaired proline metabolism in CAFs results in reduced collagen deposition and compromises the growth and metastatic spread of cancer. Moreover, the rate of proline metabolism regulates intracellular reactive oxygen species (ROS) levels, which influence the production and release of cytokines from cancer cells, contributing toward an immune-permissive TME. Hence, targeting proline metabolism is a promising anticancer strategy that could improve patients’ outcome and response to immunotherapy." Excellent review by a collaboration of University of Leicester, Cancer Research UK (CRUK) and University of Glasgow

Every week our scientific team features a publication that uses one or more product(s) available from BIOZOL that we find noteworthy. THIS WEEK: ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation (Sun et al., 2023) Proteolysis-targeting chimeras (PROTACs) are an emerging technology for therapeutic intervention, but options to target cell surface proteins and receptors remain limited. Here we introduce ROTACs, bispecific WNT- and BMP-signaling-disabled R-spondin (RSPO) chimeras, which leverage the specificity of these stem cell growth factors for ZNRF3/RNF43 E3 transmembrane ligases, to target degradation of transmembrane proteins. (…) Learn more: https://hubs.li/Q027GTns0 InVivoSIM anti-human PD-L1 (Atezolizumab Biosimilar) # SIM0009 manufactured by our partner Bio X Cell is featured in this study. #cancer #tumortherapeutics #proteindegradation #lysosome #LYTAC #PROTAC #ZNRF3 #RNF43 #Rspondin #PDL1

🔔 New insight on targeted inhibition of TGF-β signaling 🔔 🔬 Brewer et al., have recently developed a bifunctional molecule named BDPIC (bromoTAG-dTAG proximity-inducing chimera). It is capable of targeted dephosphorylation of SMAD3, the key regulator of TGF-β, impeding TGF-β-induced transcriptional responses, such as the transcription of SERPINE-1 which encodes plasminogen activator inhibitor 1. The molecule, thus, has good therapeutic potential in diseases where TGF-β dysregulation has been implicated, including fibrosis and cancer. Congratulations Authors 👏 👏 👏 👉 Read the full-text: https://lnkd.in/d-mPk-3R ✨ At Antibodies.com, we are happy to find our product, Anti-Smad3 (phospho Ser208) Antibody (A94166), citation in this interesting article (iScience. 2024 Aug 16; 27(8):110423). 🚀 Discover more, for less https://lnkd.in/dF8vGenH

🔥 𝘍𝘰𝘤𝘶𝘴 𝘰𝘯 𝘮𝘪𝘵𝘰𝘤𝘩𝘰𝘯𝘥𝘳𝘪𝘢𝘭 𝘮𝘦𝘵𝘢𝘣𝘰𝘭𝘪𝘴𝘮 #4 𝗠𝗶𝘁𝗼𝗰𝗵𝗼𝗻𝗱𝗿𝗶𝗮𝗹 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗿𝗲𝘄𝗶𝗿𝗶𝗻𝗴 𝗮𝗻𝗱 𝗰𝗵𝗲𝗺𝗼𝗿𝗲𝘀𝗶𝘀𝘁𝗮𝗻𝗰𝗲 There is ample evidence that metabolic reprogramming drives a number of cancers, and determines response to therapy. Mitochondrial metabolism is of course part of the puzzle - after all, alterations in energy metabolism are known to be important in cancer for a hundred years. However, our knowledge keeps evolving. This brand-new review discusses the most recent science as well as concepts for targeting mitochondrial metabolism as a means to overcome resistance to therapy in acute myeloid leukemia. https://lnkd.in/dXYyA6kA Full citation: Feng L, Zhang PY, Gao W, Yu J and Robson SC (2023) Targeting chemoresistance and mitochondria-dependent metabolic reprogramming in acute myeloid leukemia. Front. Oncol. 13:1244280. doi: 10.3389/fonc.2023.1244280. Freely available under a Creative Commons license: https://lnkd.in/d72Y4gs6 #science #metabolism #oncology #pharmacology #precisionmedicine

Lactate dehydrogenase A (LDHA) promotes glioblastoma progression by facilitating interaction between tumor cells and macrophages. Inhibiting LDHA disrupts this interaction, suppressing tumor growth and reducing macrophage infiltration. LDHA and its downstream signals are suggested as potential biomarkers and therapeutic targets for glioblastoma treatment. 💯 ✨ 🎉 🎊 #naturejournals #naturecommunications #glioblastoma #cancerresearch #2024goals 🤲 https://lnkd.in/dDywzfCm

𝗔𝗿𝗲 𝘆𝗼𝘂 𝗹𝗼𝗼𝗸𝗶𝗻𝗴 𝗳𝗼𝗿 𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗲𝘀 𝘄𝗶𝘁𝗵 𝗮 𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝘁𝗮𝗿𝗴𝗲𝘁 – 𝗹𝗶𝗸𝗲 𝗩𝗘𝗚𝗙-𝘁𝗮𝗿𝗴𝗲𝘁𝗶𝗻𝗴 𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗲𝘀?   The Vascular Endothelial Growth Factor (VEGF) is a protein that drives the growth of blood vessels. Although this is good for the human body, in diseases like #cancer, too much VEGF can lead to excessive blood vessel growth, aiding tumor progression. Molecules targeting VEGF are vital for inhibiting this process, slowing #tumor growth, and enhancing treatment effectiveness in conditions like cancer and other related diseases.   Get access to these and other approved molecules from original drugs in our online shop and discover the potential of clinical-grade molecules to improve research outcomes!   #evidentic #antibody #mab #clinicalgrade #researchanddevelopment #drugdevelopment #drugdiscovery #betterhealth 

𝗦𝘁𝗿𝗮𝘁𝗲𝗴𝗶𝗲𝘀 𝘁𝗼 𝘁𝗮𝗿𝗴𝗲𝘁 𝗺𝗮𝗰𝗿𝗼𝗽𝗵𝗮𝗴𝗲 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺 𝗶𝗻 𝗵𝗲𝗽𝗮𝘁𝗼𝗰𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗰𝗮𝗿𝗰𝗶𝗻𝗼𝗺𝗮 (𝗛𝗖𝗖) If the reactions to my post yesterday are any indication, quite a few of you are intereted in macrophages - so let's stick to that topic! This review is more focused than yesterdays, specifically discussing macrophage metabolism in the context of hepatocellular carcinoma. It also highlights strategies to harness those processes therapeutically. In my humble opinion, metabolism is of obvious relevance to a cancer that affects one of the, if not THE most essential metabolic organ. https://lnkd.in/drEzhFvq Full citation: Huang, J., Wu, Q., Geller, D.A. et al. Macrophage metabolism, phenotype, function, and therapy in hepatocellular carcinoma (HCC). J Transl Med21, 815 (2023). https://lnkd.in/d4Jh-8qh. Picture: figure 3 from the publication. Freely available under a Creative Commons license: https://lnkd.in/d72Y4gs6 #science #metabolism #oncology #pharmacology #precisionmedicine

#mustread Our anti-LDHD antibody was cited in a study on soft-tissue sarcoma research. The main goal of the study was to investigate the antitumoral effects of PRMT5 inhibition in soft-tissue sarcoma. PRMT5 is a member of the nine-member PRMT family enzymes, which serve as “writers” of post-translational modifications (PTMs) controlling oncogenic processes, including tumor intrinsic and extrinsic microenvironmental signaling pathways. Our anti-LDHD Triple A polyclonal antibody (HPA0417669) was used in western blot (WB) on sarcoma cell lines as one of the critical proteins involved in glycolysis. Read more here: PRMT5 function and targeting in cancer https://lnkd.in/dPjNYqCf #atlasantibodies #cancerresearch #primaryantibodies #tripleapolyclonals

Malignant #melanoma represents the most fatal #skin #cancer due to its aggressive biological behavior and high metastatic potential. In this #review, the authors summarized novel #tumor metabolic pathways and tumor-host metabolic crosstalk mechanisms leading to melanoma progression and drug resistance, with an overview on their translational potential as novel therapeutic targets. 📝 Metabolic Interplay between the Immune System and Melanoma Cells: Therapeutic Implications — Indini et al. Full text is available ➡️ https://lnkd.in/dyh4zNUg #biomarkers #medicalsciences #health #cancertreatment #medicine #metabolism