Medicines for Malaria Venture’s Post

https://lnkd.in/d5rAYECh Are you a scholar at Leaders of Africa with focus in Malaria and wondered if targeted drug administration works and need for new policy formulation. Read here👇

A new modelling study co-authored by MMV’s Director for Access & Product Management André Tchouatieu MD aims to provide guidance on new and alternative seasonal #malaria chemoprevention (#SMC) drugs and their target product profiles.     The study finds that although efficacy is crucial for reduction in malaria prevalence, chemoprevention development should select drug candidates for their duration of protection for maximum effect.     Read “Design and selection of drug properties to increase the public health impact of next-generation seasonal malaria chemoprevention: a modelling study” in The Lancet Global Health: bit.ly/3PemqNv 

🌟New in IJAA🌟 Azithromycin disrupts apicoplast biogenesis in replicating and dormant liver stages of the relapsing malaria parasites Plasmodium vivax and Plasmodium cynomolgi (Amanzougaghene et al) On the occasion of hashtag #WorldMalariaDay we are sharing this new article from ISAC Journal, IJAA. Highlights • A major obstacle to Plasmodium vivax eradication is its ability to cause relapse by the activation of hypnozoites. • The use of 8-aminoquinolines to kill hypnozoites is restricted by potential toxicity. • The apicoplast is the site of metabolic functions crucial to the survival of the malaria parasite. • This study presents evidence that azithromycin renders the hypnozoites unable to cause relapses by disrupting the apicoplast. • This work identifies apicoplast functions as potential drug targets in quiescent hypnozoites. Read more ⬇ https://lnkd.in/eKHe7Nru hashtag #Malaria #parasite #zoonoses #onehealth #multidrugresistance #infectionprevention #publichealth #globalhealth #healthcare #antibiotics #antibioticresistance #antimicrobials #InfectiousDisease

TTA and TLA Market 2024-2032 In the context of malaria treatment, "TTA" and "TLA" are not standard abbreviations or terms that are widely recognized. However, in the absence of specific context related to malaria treatment, "TTA" could potentially refer to "Tafenoquine" and "TLA" could refer to "Tafenoquine Liver Assessment." Click To get SAMPLE PDF of TTA and TLA Market @ https://lnkd.in/eWHsuBbh The Major Players Covered in this Report: Beckman Siemens Dade Roche OCD Abbot Autobio Mindry Thermo Fisher Hitachi Tecan Tomtec HTF Market Intelligence Consulting Pvt Ltd DKS Global Research #TTA #TLA #avon #crags #saasahike #plettitsafeeling #cragscarnivores #tsitsikammatourismassociation #plettpredators #medical

Targeting malaria with cholesterol attached drugs The researchers have developed a trojan horse method that tricks malaria parasites into ingesting a fatal dose of drugs by exploiting the parasite’s need for cholesterol to survive. By attaching cholesterol to drugs, the scientists can “smuggle” the drugs into the parasite where they can exert their killing effect. Lead researcher said the trojan horse method of smuggling drugs into the parasites is three to 25 times more effective at eliminating the parasites compared to drugs that aren’t attached to cholesterol. According to the scientists, this new drug delivery system of coupling drugs with cholesterol could also be used to treat other diseases including giardia, an intestinal disease responsible for causing diarrhoea. #ScienceMission #sciencenewshighlights https://lnkd.in/g-pUAQJS

April 25, 2024 World Malaria Day   #World #Malaria Day, annual observance held on April 25 to raise awareness of the global effort to control and ultimately eradicate malaria. #Malaria exists in more than 100 countries worldwide. #Malaria is preventable with the use of medicines and other precautionary measures, such as #insecticide-treated bed nets and indoor insecticide spraying.   HORIBA Medical has developed #infectious screening flags (#Yumizen h500 & #Yumizen h550) from full blood count data, based on innovative and contemporary machine-learning techniques and thousands of measurement points. The clinical performances of these flags have been assessed through on-site validation studies performed for #malaria (both #Plasmodium #vivax and #Plasmodium #falciparum) and #dengue with high #clinical sensitivity and specificity.   For further information on our products aiding these conditions, please visit our website link below and scroll down to Hematology and select CBC to find Yumizen h500 & Yumizen h550.   https://lnkd.in/dTm8cEhh

Antimalarial drug resistance remains one of the biggest challenges facing the #malaria elimination agenda. As part of MMV’s new 2024–2030 strategy, we aim to work with partners to address resistance by preserving existing antimalarials, developing and delivering new drug combinations and shortening treatment regimes.    In this video, filmed during the launch of our strategy at the 8th MIM Society Conference, MMV’s Wiweka Kaszubska, PhD and Novartis’ Nekoye Otsyula discuss this key strategic pillar and how it supports the global malaria elimination agenda. Learn more about our strategy and the goals it has set for the next 5 years: bit.ly/MMV_strategy 

We are thrilled to share insights about Arthelad (Dihydroartemisinin, 40mg piperaquine, 320mg) in the fight against malaria - providing an effective and well-tolerated option for patients. Why Arthelad? Efficacy: This combination therapy has shown high effectiveness against Plasmodium falciparum, the most deadly malaria parasite. Reduced Resistance: By combining two drugs with different mechanisms of action, Arthelad helps reduce the likelihood of resistance developing. Safety Profile: Clinical studies have demonstrated a favorable safety profile, making it a suitable choice for many patients. Local Manufacturing: Proudly manufactured locally, Arthelad ensures high quality and contributes to the local economy while making essential medicines more accessible As we continue to battle malaria globally, Arthelad reminds us of the importance of quality and affordable options in improving health outcomes. Let’s keep raising awareness and supporting efforts to eliminate malaria for good! #LaiderInternational #Orphesic #Arthelad #Flucap

https://lnkd.in/drN3wtGq The emergence of drug resistant onychomycosis in Africa is of concern and informs the need to prioritise research in this area to improve diagnostics and the availability of antifungal susceptibility testing

🚨 Bounty Alert: Earn 150$ in $RSC per Peer-Review. Could a Common Antibiotic Revolutionize Malaria Treatment and Overcome Drug Resistance? Write a peer review on Malaria Parasite Resistance To Azithromycin to earn 460 $RSC. https://lnkd.in/dheSaPGS Could PtGe clusters be the solution to CO self-poisoning in catalysts? Provide a peer review for this article and also earn 460$ in RSC. https://lnkd.in/dDefBCPz Are traditional targeted protein degradation methods falling short? Peer review this article on Protein Degradation for a 420 $RSC reward. https://lnkd.in/d74W7YPz These are the most recent peer-review bounties on @ResearchHub. Explore the live feed for more bounty opportunities. ⬇️ https://lnkd.in/duK7EF7H