Museum für Naturkunde Berlin’s Post

The Double-Edged Sword of Aging: Cellular Phenomena in Wound Healing Cellular senescence is a common phenomenon in living organisms. In wound care, however, it appears to play a negative role, impeding the wound healing processes in older subjects. Phenomena in living tissue that are beneficial at a younger age but detrimental in old age are typically genetic, known as antagonistic pleiotropy. Yet, senescence, while not a genetic issue, still falls under the same category Level 5 wound issues. ( "regulatory issues" contrary to anatomical or physiological issues (Level 4)). This brings us to an intriguing question: How do we refer to these antagonistic cellular phenomena, like senescence and micro-fibrosis due to the resolution of inflammation, which aren't strictly genetic but have similar impacts? One possible term could be "cellular antagonistic phenomena," highlighting the cellular processes that act beneficially early in life but become problematic later on. Understanding these phenomena helps us better appreciate the complex interplay between our biology and aging. It also underscores the importance of research in developing targeted interventions to mitigate these late-life challenges. What are your thoughts on these cellular trade-offs? Have you noticed any age-related changes in healing processes? Let us discuss via the comments! #woundmedicine #science #evolution #aging #biology #woundcare #cellularphenomena

🔓NEW #OpenAccess review in American Journal of Physiology - Cell Physiology: Exploring the role of urinary extracellular vesicles in kidney physiology, aging, and disease progression (Cristina Grange et al.) https://ow.ly/4XRc50QbXgJ #renalinjury #renalrubularcells #exosomes

🤔What if mammals could regenerate?! 😳 Turns out its more possible than we knew prior to studying the African spiny mouse (Acomys spp.) 🐭!!! EEEP so cute!!!! 🥰 This tiny mammal has an extraordinary ability to regenerate skin, complete with hair follicles and sweat glands, after injury, challenging the long-held belief that mammals have limited regenerative potential 🌱🔬. Imagine the possibilities – from healing wounds with unprecedented efficiency to developing innovative treatments for a range of conditions. The future of regenerative medicine looks promising! 🌟 What's even more exciting is the potential for this research to impact human medicine. Ashley Seifert, a developmental biologist, believes that the ability to regenerate damaged tissue could be activated in humans too. "By looking at the common genetic blueprints that exist across vertebrates, we hope to find the ones that we could activate in humans," he explains. "We just need to figure out how to dial the process in mammals back to do something the entire system already knows how to do." This insight could pave the way for groundbreaking advancements in medical science 🧬💉. This means that luckily for us humans and mice were derive from a common mammalian ancestor and we may be able to turn on the right set of genes to have a similar effect! If scientists continue to dive deeper into understanding the genetic and molecular pathways behind this ability. Who knows what doors this could open for enhancing human health and recovery? 🚪💡 #RegenerativeMedicine #AfricanSpinyMouse #MedicalInnovation #Biotechnology #Genetics #StemCellResearch #HealthcareInnovation #FutureOfMedicine #NatureInspired #ScienceDaily #HealingPower #MammalianRegeneration #TissueEngineering #BiomedicalScience For more fascinating details on this, check out the full article from Nature: [African spiny mice can regrow lost skin |Nature] https://lnkd.in/dE6HpCSG

Liver cells robustly adapt to nutrient fluctuations, but the subcellular remodeling involved isn’t fully understood. Gunes Parlakgul, M.D., Gökhan Hotamışlıgil, Ana Paula Arruda, and colleagues analyzed the spatial organization of mouse liver cells' organelles as nutrients fluctuate. During fasting, the endoplasmic reticulum wrapped mitochondria in large flat sheets within cells from some of the liver’s zones but not others, in a process dependent on RRBP1. In cells from obese mice, fasting failed to produce the same subcellular changes. Described in Nature Communications, the findings highlight the role of molecular architecture in liver cells' metabolic flexibility. #BroadInstitute #Science #ScienceNews #Research #ScientificResearch

Study reveals molecular mechanisms behind hibernation in mammals . Researchers have characterized changes in the structure of motor proteins, called myosins, and energy consumption that occur during hibernation, highlighting key differences in large and small hibernators. #ScienceDailynews #InnovativeResearch #NextGenScience #ExploringFrontiers

It's well known that crosstalk between the gut and the brain plays a role in numerous diseases and that gut microbiota is a key player in this communication. However, the mechanism through which the microbiota influences the development and function of the gut-brain axis remains largely unknown. In this review published in Nature, researchers explore how modulation of the gut and brain's barriers by gut microbiota can constitute an important channel of communication across the gut–brain axis. They discuss how barrier malfunction can contribute to various diseases and how understanding the molecular and cellular basis of the communication across the axis can help us gain a more accurate perspective of conditions such as "leaky gut." Check it out below and let me know your thoughts. #GastroHealth #GIHealth #DGBI

🔬 New research discovery! An intriguing pilot study using ultrasound shear wave elastography to assess the elasticity of intestinal stricture areas in Crohn's disease patients. Check out the details in the article. https://lnkd.in/dT4MnMVg #Crohns #Research #Gastroenterology #TurkishJournalofGastroenterology #TJG

SOCIALIZED MITOCHONDRIA: MITONUCLEAR CROSSTALK IN STRESS Traditionally, mitochondria are considered sites of energy production. However, recent studies have suggested that mitochondria are signaling organelles that are involved in intracellular interactions with other organelles. Remarkably, stressed mitochondria appear to induce a beneficial response that restores mitochondrial function and cellular homeostasis. 

Interesting article. Mysterious mitochondria. There are many discussions around this topic, yet we are still far from unlocking the complexity of processes created by nature. "As emphasized by Steve Jobs, there is a wealth of novel molecular biology evidence that seems unlikely to be connected, such as mitochondria-derived peptides, open reading frames, mitochondria-to-nucleus signaling, and mitochondrial stress. Will these dots connect in the future, and, if so, are we in a new era in which science and medicine will adopt a mitochondria-centric view? When that time comes, the mysteries of midi-chlorians in the Star Wars1 may unfold."

#PaperSpotlight: On April 12, 2024, researchers from the University of Oregon, The State University of New Jersey (Rutgers), The Buck Institute for Research on Aging, and the National Institute on Aging published a new research paper in Aging's Volume 16, Issue 7, entitled, “The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background.” “The ultimate goal of exploiting model organisms to screen for anti-aging interventions is to identify treatments that might translate to healthy lifespan extension in humans.” #PressRelease: https://lnkd.in/eXqp5BBC #aging #healthspan #lifespan #nematodes #genetics #newstudy #openaccess #openscience #peerreviewed #journal #publication #publishing #meded