Michael Pecota’s Post

"Revolutionizing Pharma: 3D Printing Technology The pharmaceutical industry is undergoing a significant transformation, and 3D printing is playing a key role in this change. Three printing technologies are making a significant impact: 1.⁠ ⁠Fused Deposition Modeling (FDM) •⁠ ⁠Creating personalized pills and capsules •⁠ ⁠Tailoring drug release and absorption •⁠ ⁠Enhancing patient compliance with customized dosing 1.⁠ ⁠Inkjet Printing •⁠ ⁠Developing precision-printed pills and transdermal patches •⁠ ⁠Enabling precise drug dosing and delivery •⁠ ⁠Facilitating individualized medicine 1.⁠ ⁠Powder Bed Fusion (PBF) •⁠ ⁠Producing complex drug delivery systems •⁠ ⁠Creating implantable devices and drug-eluting stents •⁠ ⁠Enabling localized drug delivery and treatment These 3D printing technologies are revolutionizing pharma by: •⁠ ⁠Enhancing drug efficacy and safety •⁠ ⁠Improving patient outcomes and compliance •⁠ ⁠Streamlining manufacturing and supply chain processes Embracing these innovations will be crucial for pharma companies to stay ahead of the curve and deliver on the promise of personalized, patient-centric care. Share your thoughts on the impact of 3D printing in pharma! Let's continue the conversation! #Pharma #3DPrinting #FDM #InkjetPrinting #PBF #PersonalizedMedicine #PatientCentricCare"

2024 PHARMACEUTICAL HOT TOPICS: Additive Manufacturing (3D Printing) 💠FOREWORD 💠 Three-dimensional (#3D) printing was discovered in the 1980s, and many industries have embraced it, but the #pharmaceuticalindustry is slow or reluctant to adopt it. The first patent on 3D printing was issued in 1986 to Charles Hull, founder of 3D systems and first commercial 3D printer was available in 1988. The advancements in the pharmaceutical field have accelerated the development of novel active pharmaceutical ingredients (#API), most of which are hydrophobic with low bioavailability and a narrow therapeutic window. The conventional dosage forms that follow the #onesizefitsallrule pose challenges in delivering API's with a narrow therapeutic window. These dosage forms do not consider the #pharmacokineticvariability, especially in pediatric and geriatric patients, often leading to either subtherapeutic action or adverse effects caused by underdose and overdose, respectively. As a result, there is a growing demand for the development of pharmaceutical formulations intended to deliver API within the therapeutic range. ‼️The use of 3D printing helps in formulating the API with a narrow therapeutic index, leading to precise doses. Furthermore, conventional dosage forms' limited drug loading capacity restricts its scope in #longactingformulations. However, the 3D-printed drug-eluting systems can incorporate large quantities of the drug and control the drug release over a period, which has gained attention over the decades. 💠Three-dimensional (3D) printing💠 3D printing, also known as #additivemanufacturing (AM), is a printing technology that builds objects layer by layer, replicating the computer-aided design (#CAD) model. Under supremacy in precision, high drug-loading, and producing complex structures, this technology is highly capable of addressing the limitations associated with conventional dosage forms and producing effective personalized medicines and medical devices. #Stereolithography (#SLA), a vat-photopolymerization technique, that uses a laser beam, is known for its ability to fabricate complex 3D structures ranging from micron-size needles to life-size organs, because of its high resolution, precision, accuracy, and speed. Due to its excellent advantages, this technology could transform the conventional “one dose fits all” concept to bring a #digitalizedpatientcentricmedication into reality. More details in the article cited below https://lnkd.in/dkJ_qF9W 💠 FDA Guidance and Resources💠 Technical Considerations for Additive Manufactured Medical Devices https://lnkd.in/dPrnXQPu If you like this post follow me on LinkedIn

https://lnkd.in/ewzjaiQf "Here are just a few potential advantages of 3D drug printing—a new system for manufacturing drugs and treatments onsite at pharmacies, healthcare facilities, and other remote locations..." Stringent quality controls will of course be required, but there are also enormous advantages including make-to-order.

3D printing of pharmaceuticals is the future! We are excited to be a part of it..check out this article to hear from our expert Thomas Kipping about this paradigm-shifting technology https://lnkd.in/ebvd5DzR

Insightful article in the field of 3D drug printing and thanks for the high regard of Triastek！#3DPrinting #drugdevelopment

This is a great advancement in pharmaceutical industry that is going to usurp personalized medicine. A new technique for 3D printing medication has enabled the printing of multiple drugs in a single tablet, paving the way for personalized pills that can deliver timed doses. The team have developed a cutting-edge method that enables the fabrication of customized pharmaceutical tablets with tailored drug release profiles, ensuring more precise and effective treatment options for patients. Using Multi-Material InkJet 3D Printing (MM-IJ3DP), tablets can be printed that release drugs at a controlled rate, determined by the tablet's design. This is made possible by a novel ink formulation based on molecules that are sensitive to ultraviolet light. When printed, these molecules form a water-soluble structure. The drug release rate is controlled by the unique interior structure of the tablet, allowing for timing the dosage release. This method can print multiple drugs in a single tablet, allowing for complex medication regimens to be simplified into a single dose. This breakthrough not only highlights the potential of 3D printing in revolutionizing drug delivery but also opens up new avenues for the development of next-generation personalized medicines. While promising, the technology faces challenges, including the need for more formulations that support a wider range of materials. The ongoing research aims to refine these aspects, enhancing the feasibility of MM-IJ3DP for widespread application. This technology will be particularly beneficial in creating medication that needs to release drugs at specific times, making it ideal for treating diseases, where timing and dosage accuracy are crucial. The ability to print 56 pills in a single batch demonstrates the scalability of this technology, providing a strong potential for the production of personalized medicines. #healthcarecosts #persanolizedmedicine #healthyaging #longevity

The Rise of 3D Printed Drugs. Imagine being able to take personalized 3D printed tablets tailored for you. Researchers from the Centre for Additive Manufacturing (CfAM) at University of Nottingham used Multi-material Inkjet 3D printing (MM-IJ3DP) to create tablets with a variety of medicines timed to be released a specific times, "enbaling highly customized drug delivery sytems with unparalleled precision." This will also simplify medication regimes and allow for highly personalized medicines for specific patients. Work continues to expand the number of drugs that can be printed. 3Dnatives Centre for Additive Manufacturing (CfAM) at University of Nottingham Yinfeng He University of Nottingham Felicity Rose #3dprinting #3dprinteddrugs #personalizedmecidine #medicine #pharmaceuticals #healthcare #customization #research #futurist #trendforecasting

In this new Q&A on Pharma's Almanac, MilliporeSigma’s Thomas Kipping, sheds light on the evolution, current state, and future prospects of 3D printing in pharma, including applications for creating innovative dosage forms and streamlining the supply of clinical trial material. #pharma #3dprinting #additivemanufacturing #clinicalsupply #osd #pharmaceuticalinnovation

How will 3D printing transform pharmaceutical manufacturing? Have a look at my recent discussion with David Alvaro from Pharma's Almanac. #pharma #manufacturing #additivemanufacturing #3Dprinting

Innovating the Future of Pharmaceuticals: A New Chapter in 3D Printing and AI Excited to unveil our latest milestone in pharmaceutical innovation: a book chapter titled "3D Printing of Pharmaceutical Products Using AI Technology," published in a prestigious volume accessible here: https://lnkd.in/dP64K8pT. This chapter represents a significant advance in the field, blending AI with 3D Printing (Additive Manufacturing) to redefine what's possible in drug production and personalized medicine. We delve into how this cutting-edge integration overcomes traditional barriers in 3D printing, such as enhancing production speeds, enabling automation, and facilitating the creation of complex, custom-tailored drug formulas. Our collaborative effort sheds light on the untapped potential of AI and Machine Learning to revolutionize pharmaceutical manufacturing, offering a blueprint for future innovations that prioritize efficiency, precision, and patient-specific care. This work not only paves the way for individualized medication solutions but also sets a new standard for the industry, moving us towards a more personalized, patient-centric healthcare model. I have heartfelt gratitude to my co-authors, Anand Kumar S, Sneha Sharma, and Dr Rajkumar Velu, for their unwavering dedication and profound insights. We are proud to contribute to this transformative journey in healthcare technology. #3DPrinting #AIinPharma #AdditiveManufacturing #PharmaceuticalManufacturing #DigitalHealth #InnovationInHealthcare