MOLECUBES NV’s Post

On July 11, at 4 PM CEST, don't miss the free webinar "Hypoxia in the Tumor Immune Microenvironment (TIME)". Prof. Zaver M. Bhujwalla, at Johns Hopkins Medicine, will review in vivo (e.g. PET/MR) and cellular and molecular (e.g. MRI/NMR spectroscopy) preclinical studies that provide new insights into varied tumor profiles/types and the underlying interplay in PD-L1 status, hypoxia, and fibroblasts in the tumor microenvironment. Such insights pave the way for improved therapies. Learn more & register: https://lnkd.in/d4SqybUe #NMR #MRI #Imaging #PreclinicalImaging #Hypoxia #Oncology

On July 11, at 4 PM CEST, don't miss the free webinar "Hypoxia in the Tumor Immune Microenvironment (TIME)". Prof. Zaver M. Bhujwalla, at Johns Hopkins Medicine, will review in vivo (e.g. PET/MR) and cellular and molecular (e.g. MRI/NMR spectroscopy) preclinical studies that provide new insights into varied tumor profiles/types and the underlying interplay in PD-L1 status, hypoxia, and fibroblasts in the tumor microenvironment. Such insights pave the way for improved therapies. Learn more & register: https://lnkd.in/dwpNG5Sx #NMR #MRI #Imaging #PreclinicalImaging #Hypoxia #Oncology

On July 11, at 4 PM CEST, don't miss the free webinar "Hypoxia in the Tumor Immune Microenvironment (TIME)". Prof. Zaver M. Bhujwalla, at Johns Hopkins Medicine, will review in vivo (e.g. PET/MR) and cellular and molecular (e.g. MRI/NMR spectroscopy) preclinical studies that provide new insights into varied tumor profiles/types and the underlying interplay in PD-L1 status, hypoxia, and fibroblasts in the tumor microenvironment. Such insights pave the way for improved therapies. Learn more & register: https://lnkd.in/d8iCUiqx #NMR #MRI #Imaging #PreclinicalImaging #Hypoxia #Oncology

On July 11, at 4 PM CEST, don't miss the free webinar "Hypoxia in the Tumor Immune Microenvironment (TIME)". Prof. Zaver M. Bhujwalla, at Johns Hopkins Medicine, will review in vivo (e.g. PET/MR) and cellular and molecular (e.g. MRI/NMR spectroscopy) preclinical studies that provide new insights into varied tumor profiles/types and the underlying interplay in PD-L1 status, hypoxia, and fibroblasts in the tumor microenvironment. Such insights pave the way for improved therapies. Learn more & register: https://lnkd.in/du8VG8yW #NMR #MRI #Imaging #PreclinicalImaging #Hypoxia #Oncology

Be sure to join our upcoming webinar titled "Hypoxia in the Tumor Immune Microenvironment (TIME)!" Registration details are in the link below. #preclinicalimaging #oncology #nuclearimaging

Tomorrow, July 11, at 4 PM CEST, don't miss the free webinar "Hypoxia in the Tumor Immune Microenvironment (TIME)". Prof. Zaver M. Bhujwalla, at Johns Hopkins Medicine, will review in vivo (e.g. PET/MR) and cellular and molecular (e.g. MRI/NMR spectroscopy) preclinical studies that provide new insights into varied tumor profiles/types and the underlying interplay in PD-L1 status, hypoxia, and fibroblasts in the tumor microenvironment. Such insights pave the way for improved therapies. Learn more & register: https://lnkd.in/d5x-Ryzh #NMR #MRI #Imaging #PreclinicalImaging #Hypoxia #Oncology

Tomorrow, July 11, at 4 PM CEST, don't miss the free webinar "Hypoxia in the Tumor Immune Microenvironment (TIME)". Prof. Zaver M. Bhujwalla, at Johns Hopkins Medicine, will review in vivo (e.g. PET/MR) and cellular and molecular (e.g. MRI/NMR spectroscopy) preclinical studies that provide new insights into varied tumor profiles/types and the underlying interplay in PD-L1 status, hypoxia, and fibroblasts in the tumor microenvironment. Such insights pave the way for improved therapies. Learn more & register: https://lnkd.in/dzAeDm-q #NMR #MRI #Imaging #PreclinicalImaging #Hypoxia #Oncology

A groundbreaking study published in the Journal of Hematology and Oncology unveils a novel pathway to combat tumor formation. Titled "Cytoplasmic Retention of CDC6 Induces Premature Senescence in Immortalized Cells and Suppresses Tumor Formation in Mice," this research sheds light on the crucial role of CDC6 in regulating senescence. 🧬 Senescence, a potent defense mechanism against tumor development, has long intrigued scientists. However, tumors often evade this process once formed, necessitating fresh approaches. This study reveals that CDC6, a cell cycle regulator, relocates from the nucleus to the cytoplasm during senescence, offering a promising avenue for intervention. 🔍 Using innovative techniques, researchers tagged CDC6 with an estrogen receptor (ER), effectively trapping it in the cytoplasm. The results were striking: cytoplasmic CDC6 not only halted cell proliferation but also triggered senescence-associated changes. Excitingly, it thwarted the transformation of mouse fibroblasts by oncogenes and suppressed tumor formation in mice. 📚 For those intrigued by the intricate interplay between cellular mechanisms and tumorigenesis, delve deeper into the study here: https://lnkd.in/g3WtK-6B #Research #Senescence #Tumorigenesis #CellBiology #ScienceTwitter

Did you miss the webinar "Hypoxia in the Tumor Immune Microenvironment (TIME)"? Watch the recording here: https://lnkd.in/drfmPfH5 Prof. Zaver M. Bhujwalla, at Johns Hopkins Medicine, reviews in vivo (e.g. PET/MR) and cellular and molecular (e.g. MRI/NMR spectroscopy) preclinical studies that provide new insights into varied tumor profiles/types and the underlying interplay in PD-L1 status, hypoxia, and fibroblasts in the tumor microenvironment. Such insights pave the way for improved therapies. #NMR #MRI #Imaging #PreclinicalImaging #Hypoxia #Oncology

📍 Nano-bio interaction of magnetic nanoparticles with cells in a tumor at the single-cell level    Pershina et al. studied penetration and distribution of PEGylated iron oxide magnetic nanoparticles (MNPs) unmodified or modified with the pH low insertion peptide (a ligand for smart targeting of the tumor acidic microenvironment) in vivo in a 4T1 mouse tumor.     Highlights  📍An scRNAseq-based approach yielded unbiased data on MNPs’ distribution among tumor cell populations.  📍Vascular burst and endothelial transcytosis can explain MNPs’ extravasation in a tumor.  📍MNPs preferentially interact with Trem2+ macrophages in a tumor and are promising for cell reprogramming.  📍Monocytes can pass MNPs on to epithelial cancer cells.  📍Conjugation with pHLIP affected MNP biodistribution in vivo. ➡ More details: https://lnkd.in/eFpxDcEB #spatialomics #spatialbiology #singlecellanalysis #singlecell