Molecular Designs’ Post

I am excited to share that our review paper on the Immunomicrotope Concept is featured on the September cover of Trends in Parasitology. The term "immunomicrotope," coined by us, describes how tissue microenvironments and diverse metabolic factors influence the fate of Leishmania parasites. In this issue of Trends in Parasitology, we highlight key cellular and molecular players in cutaneous and visceral leishmaniasis, focusing on parasite control and persistence. The cover art, Vasily Kandinsky’s Circles in a Circle (1923), beautifully captures the complexity of the immunomicrotope, symbolizing immune cells, parasites, cytokines, and blood vessels at the infection site.

#editorchoice 📢 Recurrent Loss of #Macrodomain Activity in Host Immunity and Viral Proteins 👨🎓 by Sofia E. Delgado-Rodriguez et al. 🔗 Full article: https://lnkd.in/gYUMA-xm 👉 This article belongs to the Special Issue: #ADPRibosylation in Pathogens https://lnkd.in/gjJ-SPmC The evolutionary and functional data reveal an unexpected turnover in macrodomain activity in both host antiviral proteins and viral proteins. #alphaviruses #coronaviruses

Microbiomes are an interesting topic of research, since these communities of microorganisms influence the way different environments exist, the way they do. This is relevant for humans as we too have our unique #microbiome, in the skin, gut, lungs and other sites. While we know some of the roles the microbiome plays (protection against pathogens, metabolic regulation, promoting immune system development), there is still much to be learnt. Due to my interest in #autoimmunity, I came across this paper which highlights the role of the human gut microbiome on therapies for autoimmune diseases, taking the case of Methotrexate, an immunosuppressant. Sharing this paper so you may also read what I found interesting. https://lnkd.in/dTWvbZdR

Rapid PCR: Faster Diagnosis for Infections Speed is key in diagnosing infections. Traditional methods are slow. Thankfully, rapid PCR offers a breakthrough. This technique analyzes genetic material, quickly detecting pathogens in respiratory & gastro infections. Unlike traditional PCR, it separates samples for increased accuracy. This allows for: Faster results: Get answers within hours, not days. Multiplexing: Test for multiple pathogens at once. Improved sensitivity: Detect even rare pathogens. Rapid PCR can revolutionize diagnostics. Faster, precise results mean better patient care, targeted treatment, and a stronger fight against infectious diseases. #RapidPCR #DiagnosticsRevolution #MolecularBiology #AccurateDiagnosis #FasterResults #BetterPatientCare #InfectiousDisease #RespiratoryIllness #GastroHealth #HealthcareTech

Did you know that we can use viruses to kill bacteria? 🦠   Phages, or bacteriophages, are viruses that specifically and selectively target bacteria. That means they offer a promising alternative or adjunct to antibiotics, to help kill bacteria and potentially save a life from an infection. 🎯💊   🔍 We are very excited to invite you to join the webinar “Vintage Innovation: Towards Broader Use of Bacteriophages in AMR,” focusing on the use of phages to combat AMR within the One Health framework. 🌍🔬   This webinar, led by WHO Regional Office for Europe in collaboration with the Global AMR R&D Hub, is the first in a series of three and will focus on human health. It features a panel discussion with expert scientists, clinicians, regulators, and funders in the area. 🧑🔬👩⚕️🏥   Speakers: Dr. Radu Botgros, European Medicines Agency Dr. Mariam Dadiani, The George Eliava Institute of Bacteriophages, Microbiology and Virology, Georgia Dr. Jean-Paul Pirnay, Queen Astrid Military Hospital, Belgium Dr. Shawna McCallin, Universitätsklinik Balgrist, Switzerland Dr. Mercedes Gonzalez Moreno, Leibniz HKI, Germany – INCATEurope   Moderated by: Pr Frédéric Laurent, Institut des Agents Infectieux - Hospices Civils de Lyon - HCL, Civils de Lyon Centre International de Recherche en Infectiologie, Lyon, France.   Register now! ✅ 📅 Date: April 18  ⏰ Time: 13:00 - 14:30 CEST  🔗 Register here: https://lnkd.in/d-i43Yig   #PhageTherapy #HealthInnovation #AMR #OneHealth #WHOWebinar  Tine Rikke Jorgensen Keti (Ketevan) Kandelaki Danilo Lo-Fo-Wong Lesley Ogilvie

🚨 A large plethora of research has indicated that volatile organic compounds (VOCs) in breath can be associated with infectious diseases and therefore could be used as non-invasive biomarkers. Pathogenic microbes can alter the VOCs in breath by altering metabolic pathways due to the host’s immune response. Also, with certain pathogens like bacteria and fungi, their own endogenous metabolic processes can affect the VOCs found in breath 🌬️ 📑 Our ‘Infectious Disease Hub’ provides a library of useful resources about how breath analysis can be used to collect and analyze biomarkers of infectious diseases. Head over to our hub to find out more👇: https://ow.ly/xPWT50SyusQ #infectiousdisease #biomarkers #breathanalysis

Pathogens, including viruses, bacteria, fungi, and parasites, remodel metabolism of their host to acquire the nutrients they need to proliferate. Thus, host cells are often perceived asmere exploitable nutrient pools during infection. Mounting reports challenge this perception and instead suggest that host cells can actively reprogram their metabolism to the detriment of the microbial invader. In this review, we present metabolic mechanisms that host cells use to defend against pathogens. We highlight the contribution of domesticated bacteria to host defenses and discuss examples of host–pathogen arms races that are derived from metabolic conflict #clinical research # microbiota # metabolic # science

UK researchers have successfully used a virus-based therapy to fight off infections from multi-drug-resistant bacteria in mice, marking another important step in tackling antibiotic resistance. The study at the University of Liverpool, focused on the bacteria Pseudomonas aeruginosa, which is on the World Health Organization (WHO)’s list of ‘priority pathogens’ that pose the biggest risk to human health. The bacteria is responsible for major hospital-acquired infections and has developed resistance to multiple antibiotics – meaning drugs no longer work to kill the bacteria. Using mice, the researchers tested a therapy based on bacteria-killing viruses known as bacteriophages. This phage therapy has already been touted as an alternative to antibiotics, but previously it was not understood how well it would work against P. aeruginosa in the body. Read more: https://lnkd.in/eaiCXKZD #AnimalResearch #AntibioticResistance #AntimicrobialResistance #AMR #Antibiotics #PhageTherapy #Mice

The Critical Role of Detecting Intestinal Parasites The ability to accurately identify intestinal parasites is not just a diagnostic requirement; it's important in the global fight against infectious diseases. At Goffin Molecular Technologies, we understand the urgency and importance of this mission. Our BIOSYNEX AMPLIQUICK® Protozoans and BIOSYNEX AMPLIQUICK® Helminths kits are at the forefront of molecular diagnostics, offering unmatched precision in identifying these pathogens. 🧬 BIOSYNEX AMPLIQUICK® is specifically engineered to detect 10 protozoans and 10 Helminths, utilizing real-time PCR technology. This advanced method ensures high sensitivity and specificity, providing critical support for timely and accurate diagnosis. With pre-filled microplates and streamlined PCR technology, we aim to reduce turnaround times while ensuring diagnostic accuracy. In doing so, we contribute to the global effort to control and eliminate the public health threat posed by intestinal parasites. For more information on how these diagnostic kits can impact your laboratory operations, please contact us at sales@goffinmt.com #GoffinMolecularTechnologies #MolecularDiagnostics #GlobalHealth #PublicHealthInnovation #BIOSYNEXAMPLIQUICK

#KnowledgeisPower Register for this webinar on “Vintage Innovation: Towards Broader Use of Bacteriophages in AMR,” focusing on the use of phages to combat AMR within the One Health framework.