MRI Sikho’s Post

https://lnkd.in/eWEQHjte Article title: A Brief Editorial on Clinical Presentation and Treatment of Radiation Retinopathy Following Plaque Brachytherapy of Choroidal Melanoma   Author(s): Kiran Turaka and Aruna Turaka*   Journal: Journal of Clinical Research and Ophthalmology   Journal ISSN: 2455-1414 Editorial: Treatment of choroidal melanoma with radiation plaque brachytherapy (Iodine, (I125) avoids enucleation, salvages the globe, preserves the vision, achieves better local tumor control and prevents metastasis [1,2]. However, it can lead to complications such as keratitis, iris neovascularisation, cataract, radiation optic neuropathy, retinopathy, maculopathy and vitreous hemorrhage. Radiation retinopathy (RR) is one of the expected, common complications following external beam radiation, plaque brachytherapy of choridal melanoma, retinoblastoma, choroidal metastasis and orbital tumors.1,2 The common risk factors in the development of RR are posterior choroidal melanoma nearer to the fovea (< 3 mm from fovea), large choroidal tumors (base > 10mm), tumors limited to the choroid with no anterior uveal involvement, high radiation dose, use of radioisotope Iridium (Ir192) over I125, co-existing diabetes mellitus, hypertension, and use of radiosensitisers (such as chemotherapy) [1-3]. #Aflibercept #AntiVEGFTherapy #LaserPhotocoagulation #RadiationRetinopathy #Ranibizumab #OphthalmologySubspecialties #Optometry #VisualScience #PharmacologyInEyeDiseases #BasicSciences #PrimaryEyeCare #SecondaryEyeCare #PatientSafety #QualityImprovements #NeuroOphthalmology #MedicalEyeCare #SurgicalEyeCare #GlaucomaFilteringProcedure #OcularDrugDesign #ClinicalPsychophysics #DiabeticRetinopathy #CataractSurgery #RefractiveSurgery #PVRStudies #LowVision #PterygiaStudies #PupilLightReflex #Peertechz #PeertechzPublications #SecondaryCataractStudies #RetinalDiseases #RetinalSurgery #SubstancePStudies #Cornea #ExternalEyeDisease #DefensinsForCorneaTransplants #CraniofacialClinic #OptometryClinic #OphthalmicGeneticsClinic #NeuroOphthalmologyClinic #Oculoplastics #TearingDisordersClinic #PediatricRetinaClinic #CornealNeovascularization #ImmunologicalMechanisms #MolecularMechanisms #LaserTherapyInOphthalmology #ImagingInOphthalmology #OcularImmunology #VisionAndOphthalmology #NeuroOphthalmology

📃Scientific paper: Left parathyroid carcinoma with secondary hyperparathyroidism: a case report Abstract: Background Parathyroid carcinoma is a rare disease with a frequency of 0.005% of all malignancies [1, 2]. Various aspects of its pathogenesis, diagnosis, and treatment remain poorly understood. Furthermore, cases with secondary hyperparathyroidism are fewer. In this case report, we describe a case of left parathyroid carcinoma with secondary hyperparathyroidism. Case presentation The patient was a 54-year-old woman who had been on hemodialysis since the age of 40 years. At 53 years of age, her calcium levels were high, and she was diagnosed with drug-resistant secondary hyperparathyroidism and was referred to our hospital for surgical treatment. Blood tests revealed calcium levels of 11.4 mg/dL and intact parathyroid hormone (PTH) levels of 1007 pg/mL. Neck ultrasonography revealed a 22-mm large round hypoechoic mass, partially indistinct margins, and D/W ratio > 1 at the left thyroid lobe. Computed tomography scans revealed a 20-mm nodule at the left thyroid lobe. No enlarged lymph nodes or distant metastases were noted. ^99mTc-hexakis-2-methoxyisobutylisonitrile scintigraphy revealed an accumulation at the superior pole of the left thyroid lobe. Laryngeal endoscopy revealed paralysis of the left vocal cord, signifying recurrent nerve palsy due to parathyroid carcinoma. Based on these results, a diagnosis of secondary hyperparathyroidism and suspected left parathyroid carcinoma was made, and the patient underwent surgery. Pathology results revealed hyperplasia... Continued on ES/IODE ➡️ https://etcse.fr/zCV ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

Perhaps it will be interesting to know the size of met, size of resection cavity as well as V12 Gy and V18Gy.

📃Scientific paper: Left parathyroid carcinoma with secondary hyperparathyroidism: a case report Abstract: Background Parathyroid carcinoma is a rare disease with a frequency of 0.005% of all malignancies [1, 2]. Various aspects of its pathogenesis, diagnosis, and treatment remain poorly understood. Furthermore, cases with secondary hyperparathyroidism are fewer. In this case report, we describe a case of left parathyroid carcinoma with secondary hyperparathyroidism. Case presentation The patient was a 54-year-old woman who had been on hemodialysis since the age of 40 years. At 53 years of age, her calcium levels were high, and she was diagnosed with drug-resistant secondary hyperparathyroidism and was referred to our hospital for surgical treatment. Blood tests revealed calcium levels of 11.4 mg/dL and intact parathyroid hormone (PTH) levels of 1007 pg/mL. Neck ultrasonography revealed a 22-mm large round hypoechoic mass, partially indistinct margins, and D/W ratio > 1 at the left thyroid lobe. Computed tomography scans revealed a 20-mm nodule at the left thyroid lobe. No enlarged lymph nodes or distant metastases were noted. ^99mTc-hexakis-2-methoxyisobutylisonitrile scintigraphy revealed an accumulation at the superior pole of the left thyroid lobe. Laryngeal endoscopy revealed paralysis of the left vocal cord, signifying recurrent nerve palsy due to parathyroid carcinoma. Based on these results, a diagnosis of secondary hyperparathyroidism and suspected left parathyroid carcinoma was made, and the patient underwent surgery. Pathology results revealed hyperplasia... Continued on ES/IODE ➡️ https://etcse.fr/zCV ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

SINGLE-FRACTION vs FRACTIONATED Pre-OP RADIOSURGERY (SRS) for Resected BRAIN METASTASES: A PROPS-BM International Multicenter Cohort Study Roshan S Prabhu et al., Int J Radiat Oncol Biol Phys, 2024 Mar https://lnkd.in/dGvnHXfy 404 patients with 416 resected brain metastases: *SINGLE FRACTION SRS (SF-SRS) was used for 78.5% of them *MULTIFRACTION SRS (MF-SRS) was used for 21.5% of patients - Median DOSE was 15 Gy in 1 fraction for SF-SRS and 24 Gy in 3 fractions for MF-SRS - SF-SRS was associated with HIGHER cavity LOCAL RECURRENCE compared with MF-SRS (at 2 years LC was 16.3% for the SF-SRS group vs 2.9% for the M-SRS group) - NO DIFFERENCE in TOXICITY, MENINGEAL DISEASE, or OVERALL SURVIVAL between cohorts CONCLUSIONS: Preoperative MULTIFRACTION RADIOSURGERY was associated with significantly REDUCED RISK of cavity LOCAL RECURRENCE. There was NO DIFFERENCE in TOXICITY, MENINGEAL DISEASE, or OVERALL SURVIVAL based on fractionation. MULTIFRACTION RADIOSURGERY may be a PREFERRED option for NEOADJUVANT radiation therapy of resected BRAIN METASTASES. Additional confirmatory studies are needed. #Radiosurgery #SRS #Fractionation #SingleFraction #FractianatedSRS #BrainMetastasis #Neoadjuvant #preoperation #SurgicalResection #Surgery

𝐆𝐥𝐚𝐮𝐜𝐨𝐦𝐚 𝐩𝐚𝐭𝐢𝐞𝐧𝐭𝐬. 𝐊𝐞𝐞𝐩 𝐚𝐧 𝐞𝐲𝐞… 𝐨𝐧 𝐃𝐫𝐲 𝐄𝐲𝐞! Dry eye disease (DED) has been found to occur at a higher prevalence in individuals with glaucoma than in individuals without glaucoma. Research exploring the link between glaucoma and dry eye has suggested a few potential reasons. 👁️𝐒𝐡𝐚𝐫𝐞𝐝 𝐑𝐢𝐬𝐤 𝐅𝐚𝐜𝐭𝐨𝐫𝐬: certain systemic diseases or conditions like autoimmune disorders, aging, hormonal changes, or environmental factors might increase the risk of developing both glaucoma and dry eye. However, the specific cause-and-effect relationship remains uncertain. 👁️𝐀𝐥𝐭𝐞𝐫𝐚𝐭𝐢𝐨𝐧𝐬 𝐢𝐧 𝐓𝐞𝐚𝐫 𝐅𝐢𝐥𝐦 𝐂𝐨𝐦𝐩𝐨𝐬𝐢𝐭𝐢𝐨𝐧: research suggests some glaucoma patients might have alterations in the composition of their tear film, such as changes in tear osmolarity or inflammatory markers. These alterations could contribute to the development of dry eye symptoms. 👁️𝐎𝐜𝐮𝐥𝐚𝐫 𝐒𝐮𝐫𝐟𝐚𝐜𝐞 𝐂𝐡𝐚𝐧𝐠𝐞𝐬: high intraocular pressure associated with glaucoma might affect the ocular surface and tear film stability, potentially leading to dry eye symptoms. Additionally, the structural changes in the optic nerve and eye tissues due to glaucoma could indirectly impact the ocular surface and tear film dynamics. 𝐕𝐈𝐒𝐔𝐟𝐚𝐫𝐦𝐚 𝐨𝐟𝐟𝐞𝐫𝐬 𝐚 𝐜𝐨𝐦𝐩𝐫𝐞𝐡𝐞𝐧𝐬𝐢𝐯𝐞 𝐫𝐚𝐧𝐠𝐞 𝐨𝐟 𝐩𝐫𝐨𝐝𝐮𝐜𝐭𝐬 𝐭𝐚𝐫𝐠𝐞𝐭𝐢𝐧𝐠 𝐯𝐚𝐫𝐢𝐨𝐮𝐬 𝐞𝐲𝐞 𝐜𝐨𝐧𝐝𝐢𝐭𝐢𝐨𝐧𝐬, 𝐢𝐧𝐜𝐥𝐮𝐝𝐢𝐧𝐠 𝐠𝐥𝐚𝐮𝐜𝐨𝐦𝐚. Understanding how these glaucoma products complement each other "connect the dots” to a better understanding of the disease. References: 1. Nijm LM, Schweitzer J, Gould Blackmore J. Glaucoma and Dry Eye Disease: Opportunity to Assess and Treat. Clin Ophthalmol. 2023 Oct 17;17:3063-3076. doi: 10.2147/OPTH.S420932. PMID: 37869041; PMCID: PMC10590113. 2. Baudouin C. Labbe A. Liang H. et al., "Preservatives in eyedrops: the good, the bad and the ugly", Progress in Retinal and Eye Research, 2010 3. Elhusseiny AM, et al., "The association between dry eye and glaucoma medications", Clinical Ophthalmology, 2019. 4. Gomes JAP, et al., "Recent Developments in Dry Eye Disease Treatment: A Review", Clinical & Experimental Ophthalmology, 2020 5. Weinreb RN, et al., "Primary Open-Angle Glaucoma", Nature Reviews Disease Primers, 2016

📃Scientific paper: Left parathyroid carcinoma with secondary hyperparathyroidism: a case report Abstract: Background Parathyroid carcinoma is a rare disease with a frequency of 0.005% of all malignancies [1, 2]. Various aspects of its pathogenesis, diagnosis, and treatment remain poorly understood. Furthermore, cases with secondary hyperparathyroidism are fewer. In this case report, we describe a case of left parathyroid carcinoma with secondary hyperparathyroidism. Case presentation The patient was a 54-year-old woman who had been on hemodialysis since the age of 40 years. At 53 years of age, her calcium levels were high, and she was diagnosed with drug-resistant secondary hyperparathyroidism and was referred to our hospital for surgical treatment. Blood tests revealed calcium levels of 11.4 mg/dL and intact parathyroid hormone (PTH) levels of 1007 pg/mL. Neck ultrasonography revealed a 22-mm large round hypoechoic mass, partially indistinct margins, and D/W ratio > 1 at the left thyroid lobe. Computed tomography scans revealed a 20-mm nodule at the left thyroid lobe. No enlarged lymph nodes or distant metastases were noted. ^99mTc-hexakis-2-methoxyisobutylisonitrile scintigraphy revealed an accumulation at the superior pole of the left thyroid lobe. Laryngeal endoscopy revealed paralysis of the left vocal cord, signifying recurrent nerve palsy due to parathyroid carcinoma. Based on these results, a diagnosis of secondary hyperparathyroidism and suspected left parathyroid carcinoma was made, and the patient underwent surgery. Pathology results revealed hyperplasia... Continued on ES/IODE ➡️ https://etcse.fr/zCV ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

Choroidal Metastasis from Cutaneous Melanoma with Optic Nerve and Retinal Invasion: ▪️Approximately 5% of patients with cutaneous melanoma develop distant metastases via lymphatic spread, most commonly to the lungs, liver skin, and brain, with the 5-year survival rate of approximately 22% . ▪️Very rarely, metastatic cutaneous melanoma can involve the eye and orbit, accounting for less than 5% of all ocular and orbital metastases. ▪️In cases of metastatic cutaneous melanoma to the eye, the most common primary tumor location is the trunk, followed by the upper and lower extremities, and least commonly the head and neck. ▪️Intraocular metastases are more common than extraocular metastases.  ▪️The uvea is involved in approximately 75% of cases, but other reported sites include the orbit, retina, vitreous, optic nerve, conjunctiva, and anterior chamber. ▪️Cutaneous melanoma choroidal metastases typically grow in a more rapid and aggressive manner than do primary uveal melanomas, and are often multifocal. ▪️The typical presenting symptoms in patients with intraocular metastatic cutaneous melanoma include decreased vision, floaters, pain, and red eye.  ▪️Patients may present with diplopia if the extraocular muscles are involved.  ▪️Secondary ocular complications have been reported in more than half of all affected patients, including iris neovascularization, glaucoma, uveitis, and vitreous detachment or hemorrhage. Credit: www.karger.com Photo credit: aao Ophthalmology J.

A new study highlights how MicroGenDX’s Next-Generation Sequencing (NGS) vastly improves pathogen detection in urine compared to standard urine cultures. Key Findings: -Higher Sensitivity: NGS detected pathogens in 51.7% of cases versus 43.3% by standard culture. -Enhanced Accuracy: NGS has a sensitivity of 83.3%, identifying more potential pathogens and preventing postoperative UTIs. Why It Matters: Postoperative urinary tract infections are a serious complication after stone removal procedures. Traditional urine cultures take over 48 hours and often miss certain bacteria. NGS provides faster, more comprehensive results, identifying even small amounts of bacteria, including nonculturable ones. Recommended Approach: Using NGS alongside standard cultures combines the strengths of both methods, ensuring the most accurate diagnosis and optimal treatment planning. Impact on Patient Care: Integrating NGS into preoperative evaluations can elevate patient care, accurately identifying pathogens and antibiotic resistance genes for better treatment and reduced postoperative complications. MicroGenDX is leading the way in advancing diagnostic methods for urologic surgeries, setting a new standard in pathogen detection. Read the study here: https://loom.ly/svZ_H_Q #MedicalInnovation #NextGenSequencing #MicroGenDX #Urology #HealthcareAdvancements

Bone Sarcoma: What You Need To Know In a recent article on OnlyMyHealth, Dr. Rohit Lamba, Head of Department and Senior Consultant, Bone, Joint Replacement and Orthopaedics at SHALBY Sanar International Hospitals, explains the complexities of bone sarcoma, or osteosarcoma. This rare cancer affects connective tissues, primarily in the arms and legs, and is most common in teenagers and young adults. Dr. Lamba emphasizes early detection and comprehensive treatment, including chemotherapy and limb-sparing surgery, as crucial for managing this aggressive cancer. Learn more about symptoms, diagnosis, and advancements in treatment. Read the full article for detailed insights: https://lnkd.in/gk89VyYE #BoneSarcoma #Osteosarcoma #CancerAwareness #ShalbySanarInternationalHospitals #HealthEducation Rohit Lamba