Nagendra K Chaturvedi’s Post

Should be 2nd paper on HybridDIA (or here call Hybrid-PRM/DIA), this paper is from Prof. Wollscheid's group. Simliar to 1st paper from Prof. Olsen's group, HybridDIA show higher sensitivity than DIA due to its high quality MSxPRM spectra~. Now it both paper are based on Exploris 480 and yesterday we alreday saw one-hour proteomics on Astral from Prof. Coon's group, so it isreasonable to think what will happen if HybridDIA is used in Astra 😍 ~.  

A bit belated, but I'm excited to share that one of my PhD projects was published in Cell Reports Methods! Thanks to all collaborators and labmates who helped bring this work to fruition. If you work with #organoids and are interested in understanding the proteome turnover events underlying their behavior, we encourage to try out dSILO in your system! Read more here: https://lnkd.in/eN6MWENv

I am pleased to share as a co-author of the article by Bandarra-Taveres et al., describing a novel method for the dual production of human mesenchymal stromal cells (MSCs) and their derived extracellular vesicles (EVs) in a dissolvable microcarrier-based stirred culture system. This innovative approach, developed by Prof. Claudia L. da Silva's team at Instituto Superior Técnico, Universidade de Lisboa, Portugal, addresses a critical challenge in MSC-based therapy manufacturing – achieving efficient cell retrieval free of microcarriers. This not only ensures product safety and high viable MSC yields but also enables the simultaneous production of both MSCs and their therapeutic EVs, paving the way for a cost-effective large-scale production platform. https://lnkd.in/gssbDkPf

Thrilled to share our latest paper! We investigated the antiproliferative properties of novel hyaluronan-terpyridine conjugate and its metal complexes

The Pebble Institute CIC team have just published an in-depth analysis of the immunological challenges in vascularized composite allotransplantation (VCA), specifically focusing on hand and face transplants. Read the full paper here https://lnkd.in/emi-Ftdx

Happy to share our collaborative research with SK Life Science Labs, on the selective and orally efficacious SMARCA2 degraders at #AACR "Abstract 4506: Abstract 4506: Discovery of potent, highly selective and orally efficacious SMARCA2 degraders Link for the abstract: https://lnkd.in/gZYvdS52

A nice primer for those looking to understand the basics of the CAR-T cell market landscape.

Our new Hsp90 paper is out in BiophysJ ! https://lnkd.in/dBafSvzV We studied the dimerization of Hsp90 using EPR, DEER, MST and native mass spectrometry with Michal Sharon lab. We find moderate modulation of CTD dimerization by the MDs and NTDs using a combination of biophysical tools and experimental conditions and comparing full length protein to the isolated CTDs on two (four) mutants. Enjoy! (pre-proofed)

Schedule a meeting with the experts from Discovery Life Sciences at #ASCO24

I am pleased to announce the publication of another co-authored paper in Scientific Reports in collaboration with Mikayel Ginovyan and Nikolay Avtandilyan from Yerevan State University. The study explores the combined anticancer effects of Rumex obtusifolius extract and 5-fluorouracil on A549 cells by targeting the PI3K/Akt pathway, resulting in significant apoptosis and reduced inflammatory markers. https://lnkd.in/dz2RurgT