Do you want to see how our EV solutions assist researchers in accelerating the field with new technological solutions?
In this paper, Fujiwara et. al. targets the deficiency of the conventional EV detection methods in terms of sample volume requirements and limits of detection. They hypothesized that concentrating EVs on a guided spot can help overcome the issues with currently available methodologies.
Based on this hypothesis, the researchers developed a system for optical trapping within a pressure-driven flow. By utilizing probe microparticles targeting surface markers to capture EVs from different cancer cell lines provided by us, they aimed to detect the captured EVs with confocal imaging.
Their results not only demonstrated that the sensitivity of the proposed method is more than one order of magnitude better than the gold-standard, but also the experiment duration can be reduced from hours to minutes. This way, the study set a promising example for high-throughput detection of EVs, with strong implications in early diagnostics.
If you are interested in further reading: https://lnkd.in/gBHi6Pez
#extracellularvesicles #exosomes #EVdetection #opticaltrapping #diagnostics