National Human Genome Research Institute (NHGRI)’s Post

📣Attention students, researchers, and clinical genetics lovers! Dive into the complexities of genetic results interpretation, from positive to novel findings, with #ASHG's Public Education and Awareness Committee. Register now before May 16: https://lnkd.in/ecetZCaG #HumanGenetics #GeneticsDiscoveries

New study out in Cell Genomics: "Human milk variation is shaped by maternal genetics and impacts the infant gut microbiome" https://lnkd.in/gtchfM-G Led by Dr. Kelsey Johnson, who also spoke at this year's HMI symposium, "our study provides a step toward leveraging modern human genomics techniques to characterize the factors that shape milk composition and understand how this composition impacts infant and maternal health." Excellent study connecting and integrating multi-comics datasets at intersections of the mother-milk-infant triad.

Genomics is the new frontier in antihypertensives. This highlights promising approaches and opportunities to better understand interindividual variation in treatment response https://lnkd.in/e2eDWz85

The future of medicine lies in its ability to serve everyone, regardless of their genetic background. Unfortunately, much of the current genomic research is centered around populations of European ancestry, leaving significant gaps in our understanding of how treatments affect people from diverse backgrounds. In this fascinating article by Genetic Engineering & Biotechnology News, I emphasized the critical role of genomic diversity in making medicine more equitable. We discuss the pressing need to expand genomic research beyond populations of European ancestry. Doing so will not only advance healthcare for underrepresented communities but also unlock the full potential of precision medicine for everyone. As someone deeply involved in genomic diversity research, I believe that including African and other underrepresented genomes is vital for shaping the future of medicine. 🌱🌍 The article sheds light on the strides we're making and the challenges we still need to overcome to ensure genomic equity. Read the full article here and join the conversation on how we can create a healthier future for all. #Genomics #GenomicDiversity #PrecisionMedicine #EquityInHealth #DiverseGenomes #GlobalHealth #RepresentationMatters https://lnkd.in/eqE3dAd3

#MachineLearning techniques are increasingly being explored as tools to glean insights from a wide variety of data, and #genomics datasets are no exception. Check out this recent article from the National Human Genome Research Institute (NHGRI) on the challenges and potential solutions for effectively, and ethically, integrating machine learning algorithms into genomics research.

HAPPENING TOMORROW! 📣Building from their overview of genetic technologies and their uses, our Public Education and Awareness Committee assesses the complexities of genetic results interpretation. Students, researchers, and clinical genetics lovers this is the perfect webinar for you! Register today: https://lnkd.in/ecetZCaG #ASHG #HumanGenetics

Why molecular research in butterflies? Some might see them as simply ornamental creatures, but in research, they play a crucial role in understanding evolutionary mechanisms. Certain butterflies reveal variations in patterns among populations, making them prime targets for gene-wide association studies that uncover evolutionary genomic hotspots. Ever wondered how these hotspots function and evolve? Me too! CRISPR-Cas9 really made this possible. Scientist were finally able to look at the genomic data on the computer screen and mutate it in a living organism to see if they work or are they noise - there is a lot of noise in biology. The advantage of the butterfly wing is that you see the result in-vivo in a single life cycle from caterpillar to grown butterfly. The CRISPR perturbation assays are interpreted as changes in a single wing scale-cell; they reveal themselves as a clonal mosaic aberration on the wing. Much like different colored tiles cutting through an otherwise generic brown clay tile roof. #TLDR I sit here reflecting on how best to attract attention to my CV. I wonder if recruiters in the tech industry truly grasp the profound insights this research offers on disease processes such as cell identity, gene regulation, and as we discovered - non-coding RNA elements. I believe this field offers deep value in the general understanding of molecular - health related mechanisms.

“It’s time to admit that genes are not the blueprint for life.” Healthcare is about to explode with new possibilities through a better understanding of genetics! Scientists in epigenetics – the study of how environmental factors can influence gene expression without altering the DNA sequence – are increasingly uncovering the intricate relationship between genes and their environment. This emerging perspective challenges the notion of genes as life’s unchangeable blueprint, suggesting instead that life is a dynamic process shaped by both genetic and non-genetic factors. This shift in our understanding should promise advancements in personalized medicine, sustainable agriculture, and a deeper understanding of biodiversity. Evolutionary biology also benefits from this differing perspective, as it is becoming ever clearer that evolution is not only a story of genetic mutations but also of how organisms adaptively respond to their environments through changes in gene expression. The implications of this shift for medicine are even more profound, as it suggests that diseases and health conditions may require more than just targeting genes. This would mean that lifestyle, diet, and environment have exceptionally important roles in health and disease. Medicine is about to get a lot more holistic... How are you going to improve your health? #CXAdvisory #Health #Pharma #Epigenetics

Genetically-diverse crowds are wiser A fundamental question in the social sciences is how collectives of individuals form intelligent judgments. This article tests the hypothesis that genetically-diverse groups make better collective judgments than genetically more homogenous groups. Two studies were conducted (a total of N = 602 participants) in which sets of twins (both monozygotic and dizygotic) were required to perform the task of making numerical judgments. The accuracy of the judgments made by pairs of participants—who were either co-twins (i.e., genetically-related) or were not related—was then compared. The results indicate that the judgments made by unrelated pairs were more accurate than those of the genetically-related twins. Critically, however, this superior performance was found only among monozygotic twins, evidencing the role of genetic relatedness in collective judgment. This research provides the first empirical demonstration of the benefit of genetic diversity for collective judgments, shedding light on the origins of the ‘wisdom of crowds’ phenomenon. Past studies suggested that combining individuals' judgments improves accuracy. Accuracy is leveraged when individuals vary in terms of background, education, and demography. The researchers proposed that genetic diversity contributes to the accuracy derived from combining judgments. They collected a total of 602 monozygotic and dizygotic twins, who made numerical judgments. Genetically-heterogeneous pairs of judges were more accurate than genetically-homogenous ones. https://lnkd.in/e-ivs7nY

🎉 India's Milestone Achievement in Genomics 🎉 Human genome sequencing is more than just mapping out DNA; it's about unlocking the code of life itself. This process allows scientists to dive deep into the genetic instructions that make up a human being, offering insights into how genes interact, influence our health, and are passed down through generations. India's achievement in sequencing 10,000 human genomes is a monumental step forward in the global endeavor to understand human genetics. It not only contributes to a global understanding but also emphasizes the need for a India-specific genetic database to address unique healthcare challenges. This accomplishment is a beacon of hope for personalized medicine, promising a future where treatments and medications are tailored to the genetic makeup of individuals, minimizing risks and maximizing efficacy. Let's applaud the researchers and everyone involved in the Genome India project for their dedication and hard work. Here's to more breakthroughs and advancements in the field of genomics! #GenomeIndia #HumanGenomeSequencing #personalizedmedicine #genomics #healthcareinnovations #cellandgenetherapy https://lnkd.in/gZPMxCzK