Nithya B’s Post

Psoriasis Severity Linked to Imbalance in Skin Microbiome A new study published in Lancet has revealed a connection between the severity of psoriasis and imbalances in the skin microbiome. Researchers found that patients with severe psoriasis have a disrupted skin microbiome, characterised by decreased diversity and an overabundance of certain harmful bacteria. This imbalance, known as dysbiosis, can worsen inflammation and exacerbate psoriasis symptoms. The findings suggest that targeting the skin microbiome through treatments like probiotics could potentially alleviate psoriasis symptoms and improve patient outcomes. Further research is needed to explore these therapeutic approaches. Link to Study: https://lnkd.in/gWyd37js #microbiome #metagenomics #skinhealth #skinmicrobiome #dybiosis #psoriasis

In a Jan 2024 article in the European Journal of Internal Medicine, the authors review the relationship between gut microbes and metabolic disorders as well as the promise for therapeutic microbiome manipulations: Highlights include: • Gut microbiota plays a key role in health maintenance with consequence on metabolic homeostasis. • Gut dysbiosis contributes to derangement of several metabolic pathways. • External manipulation of gut microbiota is a promising therapeutic tool. • Poor standardization and translational value of current studies require further evidence. Read the full article: https://lnkd.in/grd8pTHe #obesity #gutmicrobiome #metabolomics

A new study in Diabetology & Metabolic Syndrome has investigated the link between metabolic syndrome and the risk of developing primary open-angle glaucoma, a condition characterized by the gradual loss of retinal ganglion cells and optic nerve degeneration, eventually leading to irreversible vision loss. Analyzing data from the 2019-2021 Korean National Health and Nutrition Examination Survey, encompassing 11,499 adults aged 19 years and above, the researchers categorized participants into groups based on the presence or absence of metabolic syndrome. Findings revealed a notable dose-response relationship between the number of metabolic syndrome components a person had and their risk of developing primary open-angle glaucoma. Consequently, the study suggests that people with metabolic syndrome, who are at a heightened risk of primary open-angle glaucoma, especially normal-tension glaucoma, should undergo comprehensive ophthalmological evaluations as a preventive measure. — Lee, JH., Kwon, YJ., Kim, S.J. et al. Metabolic syndrome as an independent risk factor for glaucoma: a nationally representative study. Diabetol Metab Syndr 15, 177 (2023). 📌 Link to study: https://lnkd.in/g2G3Nevg 📌 Find more research summaries on our website: https://lnkd.in/gKeXEcEN #Keto #Ketogenicdiet #Nutritionaltherapy #Research

📢 The Gut-Kidney Connection 📰 Thanks Majd Isreb, MD, FACP, FASN, IFMCP and Integrative Kidney Institute for sharing thus interesting study! Short Chain Fatty Acids (SCFA) like Propionate and Butyrate are a function of healthy/balanced gut bacteria. The levels of SCFA produced by the microbiome affect gut health and can contribute to the development of several diseases 👉🏽 including kidney disease. The study demonstrated that: 1️⃣ levels of propionate and butyrate in stool were lower in CKD patients and gradually reduced as the disease progresse 2️⃣ "Early administration of these SCFAs prevents disease advancement in a pre-clinical model of acute renal damage, demonstrating their therapeutic potential independently of the gut microbiota." ✨️ This is a major step in better understanding the role of applying an Integrative lense in renal care by supporting gut health and mucrobiome balance as a foundation in protecting kidney health. Read the full article here: https://lnkd.in/euYXKQvv ❇️ From your experience, what do you think of this study or the gut-kidney connection? #kidneydisease #pharmacist #integrativemedicine #nephrology #microbiome

𝗙𝗮𝘁 𝗰𝗲𝗹𝗹𝘀, 𝗱𝗶𝗲𝘁, 𝗮𝗻𝗱 𝗱𝗶𝗮𝗯𝗲𝘁𝗲𝘀 🔬 Join us for the #DiabetesResearchSeminar featuring Laurem Solís from the Coskun group at the Paul-Langerhans-Institut Dresden of the German Center for Diabetes Research (DZD e.V.). 🗓 Date: Tuesday, November 5 🕒 Time: 3:00 PM 📍 Location: BCUBE E73 + E74 Laurem will be presenting her talk titled, "𝘉𝘦𝘺𝘰𝘯𝘥 𝘏𝘪𝘨𝘩 𝘍𝘢𝘵 𝘋𝘪𝘦𝘵: 𝘛𝘩𝘦 𝘙𝘦𝘭𝘦𝘷𝘢𝘯𝘤𝘦 𝘰𝘧 𝘍𝘢𝘵𝘵𝘺 𝘈𝘤𝘪𝘥 𝘚𝘢𝘵𝘶𝘳𝘢𝘵𝘪𝘰𝘯 𝘧𝘰𝘳 𝘵𝘩𝘦 𝘪𝘯𝘵𝘦𝘳𝘢𝘤𝘵𝘪𝘰𝘯 𝘸𝘪𝘵𝘩 𝘍𝘈𝘉𝘗5." Join us in this seminar exploring the factors affecting lipid metabolism and its role in #diabetes pathology and connect with fellow researchers. #DiabetesResearch #FattyAcids #Metabolism

Gut-Brain Connection: The Role of Dietary Proline in Depression At #TargetingMicrobiota2024, José Manuel Fernández-Real from Universitat de Girona, Spain, presented his latest data on the topic. Key Takeaways: 🔹 Dietary Impact: High proline consumption significantly influences depression. 🔹 Brain Network Disruption: Proline levels correlate with changes in brain dynamics associated with depressive symptoms. 🔹 Mouse Models: Proline supplementation worsened depression-like symptoms, while human microbiota transplantation induced emotional impairment. 🔹 Protective Strategies: Innovations in targeting proline and GABA transporters showed potential in alleviating depression-like states. #InternationalSocietyofMicrobiota #TargetingMicrobiota #microbiomeresearch #microbiome #microbiota #guthealth #gutbrainaxis #neurologicaldisorders

¿Ya lo conoce? #SaludMetabólica #HafniaAlvei #ProbioSatys #Obesidad 1. Gut microbiota and obesity: role in aetiology and potential therapeutic target. Carthage Moran  31 Jul 2014-Best Practice & Research in Clinical Gastroenterology 2. Gut microbiota in obesity Bing-Nan Liu  06 Jul 2021-World Journal of Gastroenterology 3. Hafnia alvei HA4597 Strain Reduces Food Intake and Body Weight Gain and Improves Body Composition, Glucose, and Lipid Metabolism in a Mouse Model of Hyperphagic Obesity. Nicolas Lucas  22 Dec 2019 4. The Probiotic Strain H. alvei HA4597 ® Improves Weight Loss in Overweight Subjects under Moderate Hypocaloric Diet: A Proof-of-Concept, Multicenter Randomized, Double-Blind Placebo-Controlled Study. Pierre Déchelotte  31 May 2021-Nutrients 5. 5. An overview of microbiome based strategies on anti-obesity. Cherng Shyang Chang  31 Dec 2018-Kaohsiung Journal of Medical Sciences

🔬 Emerging research from the FINRISK cohort reveals that gut microbiota diversity isn't just a marker of overall health but may play a critical role in bone integrity, with specific bacterial phyla like Proteobacteria linked to higher fracture risk and Tenericutes to reduced risk. Beyond these associations, the study delves into the functional pathways involved—highlighting amino acid metabolism and butyrate synthesis as key players—which could open new avenues for microbiome-targeted therapies in bone health and fracture prevention. This underscores the profound interconnectedness between gut health and skeletal strength, emphasizing the need for a holistic approach to personalized medicine. #Microbiome #BoneHealth #PrecisionMedicine #TheriomeInsights https://lnkd.in/g637ft3U

Gut Microbiome Breakthrough in Age-Related Gout 🌱🦠🔍 New research reveals a strong link between age-related changes in gut bacteria and gout susceptibility. "Younger" gut bacteria may improve gut health and reduce gout risk in older individuals. Additionally, butyrate, a beneficial compound produced by certain gut bacteria, may offer a potential therapeutic avenue for managing gout by reducing inflammation and lowering uric acid levels. This research highlights the potential of gut microbiome-based therapies for this painful condition. #guthealth #gout #microbiome #aging #healthyaging #research https://lnkd.in/de3Wtdk8

Research studies on Psyllium husk showed a significant reduction in the symptoms of irritable bowel syndrome and other GI conditions. It helps get things moving, helps water retention in the intestines, and improves constipation and diarrhea. Plus, Plantago Psyllium, as a rich source of fiber, feeds the gut microbiome and stabilizes the quality microbiota population in the gut. Psyllium husk or seeds may also help get rid of parasites and may help conditions like diverticulosis [4, 5] References: 4. Dossett ML, Cohen EM, Cohen J. Integrative Medicine for Gastrointestinal Disease. Prim Care. 2017 Jun;44(2):265-280. doi: 10.1016/j.pop.2017.02.002. PMID: 28501229; PMCID: PMC5605819. 5. Bahrami HR, Hamedi S, Salari R, Noras M. Herbal Medicines for the Management of Irritable Bowel Syndrome: A Systematic Review. Electron Physician. 2016 Aug 25;8(8):2719-2725. doi: 10.19082/2719. PMID: 27757180; PMCID: PMC5053451