Introducing PEV: Personalized Cancer Vaccine! 🧬𝗣𝗘𝗩 𝗨𝗻𝘃𝗲𝗶𝗹𝗲𝗱: 𝗣𝗲𝗿𝘀𝗼𝗻𝗮𝗹𝗶𝘇𝗲𝗱 𝗖𝗮𝗻𝗰𝗲𝗿 𝗩𝗮𝗰𝗰𝗶𝗻𝗲 𝗠𝗮𝗴𝗶𝗰 PEV, the acronym that signifies hope, stands for Personalized Cancer Vaccine—a groundbreaking marvel in the world of oncology. This innovative vaccine is meticulously crafted based on the unique neoantigens extracted from each patient's individual tumor mutanomes. 🔬 𝗡𝗼𝘂𝘀𝗰𝗼𝗺'𝘀 𝗦𝘆𝗺𝗽𝗵𝗼𝗻𝘆: 𝗔 𝗥𝗼𝗯𝘂𝘀𝘁 𝗠𝗮𝗻𝘂𝗳𝗮𝗰𝘁𝘂𝗿𝗶𝗻𝗴 𝗣𝗿𝗼𝗰𝗲𝘀𝘀 Enter the world of Nouscom , where science meets precision! Nouscom has masterfully developed a robust and swift manufacturing process that transforms a patient's biopsy into the release of their personalized vaccine. Crafted on an unprecedented number of neoantigens. From biopsy to vaccine, it's a journey of efficiency and breakthroughs. 🧪𝗩𝗶𝗿𝗮𝗹 𝗖𝗵𝗼𝗿𝗲𝗼𝗴𝗿𝗮𝗽𝗵𝘆: 𝗚𝗔𝗱 𝗮𝗻𝗱 𝗠𝗩𝗔 𝗧𝗮𝗸𝗲 𝘁𝗵𝗲 𝗦𝘁𝗮𝗴𝗲 Picture this as a dance of science! PEV's technology relies on the coordinated performance of two star viral vectors—GAd and MVA. GAd takes the lead in priming, setting the stage for immune activation. MVA follows, boosting the immune response to unprecedented heights. 🚀 𝗣𝗿𝗶𝗺𝗶𝗻𝗴 𝘄𝗶𝘁𝗵 𝗚𝗔𝗱: 𝗦𝗲𝘁𝘁𝗶𝗻𝗴 𝘁𝗵𝗲 𝗜𝗺𝗺𝘂𝗻𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗣𝗿𝗲𝗹𝘂𝗱𝗲 GAd, the priming partner, elegantly introduces the immune system to the newly identified neoantigens. It's the opening act that prepares the immune orchestra for the grand symphony ahead. 🎆 𝗕𝗼𝗼𝘀𝘁𝗶𝗻𝗴 𝘄𝗶𝘁𝗵 𝗠𝗩𝗔: 𝗘𝗹𝗲𝘃𝗮𝘁𝗶𝗻𝗴 𝘁𝗵𝗲 𝗜𝗺𝗺𝘂𝗻𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗖𝗿𝗲𝘀𝗰𝗲𝗻𝗱𝗼 As the anticipation builds, MVA enters the scene as the boosting virtuoso. With precision and power, it elevates the immune response to a crescendo, creating a symphony of T cells ready to take on the cancer cells. 🛡 𝗧𝗵𝗲 𝗚𝗿𝗮𝗻𝗱 𝗙𝗶𝗻𝗮𝗹𝗲: 𝗣𝗼𝘁𝗲𝗻𝘁 𝗧 𝗖𝗲𝗹𝗹 𝗥𝗲𝘀𝗽𝗼𝗻𝘀𝗲 𝗧𝗮𝗸𝗲𝘀 𝗖𝗲𝗻𝘁𝗲𝗿 𝗦𝘁𝗮𝗴𝗲 As the final notes of this scientific symphony echo, a potent T cell response emerges—a formidable force ready to seek and eliminate cancer cells with unparalleled precision and strength. 🎻🔍 🎉 𝗖𝘂𝗿𝘁𝗮𝗶𝗻𝘀 𝗥𝗶𝘀𝗲: 𝗖𝗮𝗻𝗰𝗲𝗿 𝗖𝗲𝗹𝗹𝘀 𝗘𝗹𝗶𝗺𝗶𝗻𝗮𝘁𝗲𝗱, 𝗛𝗼𝗽𝗲 𝗣𝗿𝗲𝘃𝗮𝗶𝗹𝘀 The curtains rise on a stage of triumph! Thanks to PEV's personalized touch, cancer cells are met with the relentless force of the immune orchestra, and hope prevails in the face of adversity. Amidst applause and cheers, PEV takes a well-deserved bow, symbolizing a new era in cancer treatment—personalized, precise, and powerful.
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Proactive Biotechnologist | Expertise in Research and Management | Bridging Quality Science and Leadership for Innovation.
Personalized Cancer Vaccine: The Future of Melanoma Treatment | Aakash Khurana Exciting news for melanoma patients! Researchers are developing a personalized vaccine that uses a patient's own tumor DNA to train their immune system to fight cancer cells. #melanoma #cancertreatment #personalizedmedicine #cancersupport #cancerresearch #livingwithcancer #thrivingwithcancer #youarenotalone #hope #clinicaltrials #personalizedmedicine #dna #immunotherapy #medicalbreakthrough #neoantigenvaccine Researchers are developing a personalized cancer vaccine for melanoma. There's promising research on a new type of melanoma vaccine, but it's important to clarify a few points: Permanently Cure: While the results are exciting, it's too early to say this vaccine definitively cures melanoma permanently. Current trials show a significant reduction in recurrence, but long-term data is still needed. Custom-Made Tumor DNA: You're exactly right! This vaccine is personalized using a patient's own tumor's DNA. This lets the immune system recognize and target the specific cancer cells. Marker Neoantigen: These are unique proteins on the surface of cancer cells. The vaccine trains the immune system to identify these markers and attack the cancer cells. Current Stage: This type of vaccine is undergoing clinical trials and shows promise. Early results indicate a significant reduction in the risk of melanoma recurrence when combined with immunotherapy [3]. However, it's important to note that it's not yet a permanent cure, and more research is needed. Benefits: Personalized approach: Targets the specific patient's cancer. Trains the immune system: Teaches the body to recognize and fight cancer cells. Limitations: Still in development: Long-term effects and permanent cure rates need further study. Time factor: Creating a personalized vaccine can take time, which might be crucial for advanced stages. Here's a breakdown of how it works: * Tumor Analysis: Doctors extract DNA from a patient's tumor. * Neoantigen Identification: Scientists analyze the DNA to identify neoantigens. * Vaccine Creation: Using these neoantigens, a personalized vaccine is created using mRNA technology (similar to some COVID-19 vaccines). * Immune System Training: The vaccine is administered to the patient, training their immune system to recognize and attack the cancer cells with the specific neoantigens. Overall: This personalized vaccine approach is a significant step forward in melanoma treatment. While not a permanent cure yet, it holds great promise for improving patient outcomes. Clinical trials have shown a significant reduction in melanoma recurrence when this personalized vaccine is combined with immunotherapy drugs. for more info: https://lnkd.in/gpQCCJ4x
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The fight against cancer is reaching new heights with cutting-edge innovations like DoriVac, a DNA origami-based vaccine technology developed in collaboration at the Wyss Institute at Harvard University and Dana-Farber Cancer Institute. DoriVac works by boosting the body’s immune system to recognize and attack cancer cells more effectively. By using DNA origami structures to precisely deliver antigens that trigger a targeted immune response, DoriVac offers a highly customizable approach to cancer treatment. This breakthrough technology could pave the way for more potent cancer vaccines, capable of treating a range of cancers with fewer side effects than traditional therapies. As personalized medicine continues to evolve, technologies like DoriVac represent the next frontier in immunotherapy, providing hope for more effective cancer treatments.
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Early cancer detection, single cell genomics, AI/ML, targeted therapies, ADCs and cancer vaccines were some of the focus topics at AACR 2024. As AACR supports more and more clinical readouts, the conference was filled with exciting, mostly early data across both heme and solid tumors. From an immuno-oncology perspective, there were a few promising, and interesting readouts for cancer vaccines, with data across metastatic and earlier stage disease. Preliminary evidence of clinically relevant activity in the adjuvant settings demonstrated by BioNtech’s mRNA neoantigen vaccine, autogene cevumeran (ICI + chemo combination) in pancreatic cancer and Diakonos’ dendritic cell vaccine in glioblastoma (GBM) further validate the potential of this long-studied modality. Furthermore, these data showed the potential beyond ‘hot’ tumors like melanoma, HNSCC, and NSCLC, in ‘cold’ tumors like PDAC and GBM. Additional promising early readouts from companies like Transgene (multi-neoantigen vaccine) in the adjuvant setting in HPV- HNSCC, and Geneos (DNA neoantigen vaccine GNOS-PV02 + ICI) in R/R metastatic HCC further underscore the broad potential of the modality across cancers and lines of therapy. However, despite the overall increasing interest and development in cancer vaccines (higher number of programs in 2023 vs. 2018), with potential imminent approvals for programs like Moderna’s mRNA vaccine in early-stage melanoma (maybe as early as 2025 in a few countries with accelerated approval), the space continues to be fraught, with multiple less than ideal data readouts this year so far (e.g. Gritstone’s P2 study in CRC and Ultimovacs’ P2 study in melanoma). Additionally, there was less cancer vaccine based deal-making in 2023 vs. pre-COVID years (based on # of deals), highlighting the need for a continued, sustained effort across academia, biotech and pharma to facilitate the development and relevance of vaccines in oncology. As we move forward, a better understanding and optimization of cancer vaccines (delivery, antigen, adjuvant and other technical aspects), clinical development strategy, and the underlying tumor and TME biology (need for appropriate combinations, whether with ICIs and/or other agents) is going to be key in propelling the field forward. As Vinod Balachandran from MSKCC aptly said at his PDAC presentation at AACR, the right antigen, right delivery technology and right setting continue to remain critical for developing an effective vaccine in oncology. Overall, all things considered, in my opinion, cancer vaccines continue to have a strong potential to make a significant impact in the near and long-term as an effective and safe IO modality across multiple tumors, stages of disease, and patient populations. Looking forward to discussing cancer vaccines and the evolving IO landscape at the Lumanity cancer progress webinar "What’s Next for IO: What and When Is the Next Game Changer?" that I am co-moderating with Jeff Bockman on April 30th.
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𝗕𝗿𝗲𝗮𝗸𝗶𝗻𝗴 𝗡𝗲𝘄𝘀: 𝗣𝗲𝗿𝘀𝗼𝗻𝗮𝗹𝗶𝘀𝗲𝗱 𝗖𝗮𝗻𝗰𝗲𝗿 𝗩𝗮𝗰𝗰𝗶𝗻𝗲𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗶𝗻 𝘁𝗵𝗲 𝗡𝗛𝗦 In my 30+ years of treating colorectal cancer we have aways tried to think about a personalised approach to treatment using a patients specific biology and genetic sequence. My PhD thesis at Queen Mary University of London and Bristol Myers Squibb, Princeton was using gene expression to stratify risk on patients with colorectal cancer. Therefore this new development is very exciting. The NHS has announced the access to personalised cancer vaccines following the launch of the NHS Cancer Vaccine Launch Pad. The NHS has treated its first patient with colorectal cancer. In a national first, father-of-four Elliot Phebve received the vaccine at University Hospitals Birmingham NHS Foundation Trust, one of several sites taking part in the colorectal cancer vaccine trial sponsored by BioNTech SE. The German biotechnology company will present new preliminary data at American Society of Clinical Oncology (ASCO) on how measuring circulating tumour DNA could potentially help early detection of colorectal cancer. The investigational cancer vaccines evaluated in the colorectal cancer trial are based on mRNA – the same technology used for the Pfizer-BioNTech COVID-19 vaccine – and are created by analysing a patient’s tumour to identify mutations specific to their own cancer. Using this information, researchers then create an experimental individualised cancer vaccine. 𝗧𝗵𝗲 𝗖𝗼𝘃𝗶𝗱 𝗩𝗮𝗰𝗰𝗶𝗻𝗲 𝗟𝗮𝘂𝗻𝗰𝗵 𝗣𝗮𝗱 The CVLP is a platform that will speed up access to messenger ribonucleic acid (mRNA) personalised cancer vaccine clinical trials for people who have been diagnosed with cancer. It will also accelerate the development of cancer vaccines as a form of cancer treatment Through the CVLP, people with cancer who are receiving treatment in the NHS in England can be assessed to see if they might be eligible to join a cancer vaccine clinical trial, and then referred to a hospital that is running a trial. Over time, the CVLP will enable patients to access multiple trials running in different NHS trusts in other parts of the country, increasing access in an equitable way. Utilising the unique benefits of the NHS as an innovation partner, the collaboration aims to provide up to 10,000 patients with personalised cancer treatments in the UK by 2030. It is set up by NHS England and Genomics England and works in parallel with the existing NHS Genomic Medicine Service. Last year, the Government signed an agreement with BioNTech to provide up to 10,000 patients with precision cancer immunotherapies by 2030.
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A Complete Guide On #Cancer_Immunotherapy [Latest Edition] 𝗗𝗼𝘄𝗻𝗹𝗼𝗮𝗱 𝗙𝗿𝗲𝗲 𝗘-𝗣𝗗𝗙: https://lnkd.in/gEm-tHcZ The global cancer immunotherapy market is experiencing significant growth, driven by the rising incidence of cancer and the increasing adoption of immunotherapy as a treatment method. According to Fact.MR, the market is projected to expand at a robust CAGR of 9.5%, reaching a valuation of US$ 412.8 billion by 2034 from its current size of US$ 166.4 billion in 2023. This surge is attributed to advancements in immunotherapeutic approaches, including checkpoint inhibitors, monoclonal antibodies, and CAR-T cell therapies, which are revolutionizing cancer treatment by harnessing the body’s immune system to target and destroy cancer cells. Additionally, supportive government policies and significant investments in research and development are further propelling the market's growth, positioning cancer immunotherapy as a crucial component in the future landscape of oncology treatments. Cancer immunotherapy represents a revolutionary approach to cancer treatment, utilizing the body's immune system to identify, target, and destroy cancer cells. Unlike traditional treatments such as chemotherapy and radiation, which directly attack cancerous tissues but also harm healthy cells, immunotherapy aims to boost the immune system's natural defenses to fight cancer more effectively and with fewer side effects. This form of therapy encompasses a variety of strategies, including monoclonal antibodies, immune checkpoint inhibitors, cancer vaccines, and adoptive cell transfer (like CAR-T cell therapy). Monoclonal antibodies work by attaching to specific proteins on cancer cells, marking them for destruction by immune cells. Immune checkpoint inhibitors, such as those targeting the PD-1/PD-L1 and CTLA-4 pathways, remove the 'brakes' on the immune system, enabling it to attack cancer cells more vigorously. CAR-T cell therapy involves modifying a patient’s own T-cells to better recognize and combat cancer cells, offering personalized and potent treatment options. The United States leads the North American market and is set to capture a share of 45.6% by 2034. This can be attributed to favorable market dynamics such as progressive improvements in healthcare infrastructure and government initiatives in the mode of subsidies supporting key market players in carrying out R&D activities. Furthermore, market players are also expected to receive benefits from the United States federal government, such as tax exemptions and market exclusivity. Growing number of awareness campaigns regarding the diagnosis and treatment of cancer is also complementing cancer immunotherapy demand growth in the United States. #Health #Healthcare #Pharma #Cancer #Immunotherapy #Therapy #Immunesystem #Solutions
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Unlocking the Potential of mRNA Vaccines in Cancer Immunotherapy The quest to revolutionize cancer vaccines has reached a significant milestone with the development of multi-lamellar RNA lipid-particle aggregates (RNA-LPAs). This innovative approach has yielded promising results in its first-in-human trial. It showcases the potential to reprogram the tumor microenvironment and elicit a vigorous immune response against solid tumors and hematologic malignancies. Key Highlights: 1. Overcoming Immunological Barriers: The RNA-LPA vaccine, encapsulating mRNA in an 'onion-like' structure, has demonstrated the ability to overcome the immunosuppressive tumor microenvironment, shifting tumors from 'cold' to 'hot' within 48 hours of administration. 2. Personalized Cancer Immunotherapy: Using patient-specific mRNA extracted from their own tumor allows for a highly personalized vaccination strategy, creating opportunities for earlier and enhanced immune activation. 3. Upcoming Clinical Trials: The next phase involves a comprehensive Phase I clinical trial involving both adult and pediatric patients, with plans to extend the collaboration to deliver personalized vaccines across children's hospitals in the USA. This groundbreaking research signifies a monumental leap forward in cancer immunotherapy and holds the potential to reshape the landscape of personalized cancer vaccines. Trailblazing a path toward harnessing the full potential of mRNA vaccines in combating cancer, setting the stage for a paradigm shift in cancer treatment. For details, please check Mendez-Gomez HR, DeVries A, Castilla P, et al. RNA aggregates harness the danger response for potent cancer immunotherapy Cell doi:10.1016/j.cell.2024.04.003 (2024)(Epub ahead of print). #CancerImmunotherapy #mRNAVaccines #PersonalizedMedicine #HealthcareInnovation
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𝐇𝐚𝐫𝐧𝐞𝐬𝐬𝐢𝐧𝐠 𝐍𝐚𝐭𝐮𝐫𝐞’𝐬 𝐃𝐞𝐟𝐞𝐧𝐬𝐞: 𝐓𝐡𝐞 𝐅𝐮𝐭𝐮𝐫𝐞 𝐨𝐟 𝐂𝐚𝐧𝐜𝐞𝐫 𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 Cancer immunotherapy is a groundbreaking treatment approach that harnesses the body's immune system to combat cancer. Unlike traditional therapies, which directly target tumors, immunotherapy enhances the immune response, enabling the body to recognize and destroy cancer cells more effectively. 𝐒𝐚𝐦𝐩𝐥𝐞 𝐓𝐎𝐂: https://lnkd.in/gCs5DBVU 𝐂𝐡𝐞𝐜𝐤𝐩𝐨𝐢𝐧𝐭 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬: These drugs target #molecules known as immune checkpoints, which are proteins that regulate the activity of #immune cells. By blocking these checkpoints, checkpoint inhibitors help to unleash the immune system's response against #cancercells. Examples include drugs like pembrolizumab (Keytruda) and nivolumab (Opdivo). 𝐂𝐀𝐑-𝐓 𝐜𝐞𝐥𝐥 𝐭𝐡𝐞𝐫𝐚𝐩𝐲: Chimeric Antigen Receptor T-cell therapy (CAR-T) involves modifying a patient's own T cells in the laboratory to express chimeric antigen receptors (CARs) that can recognize and bind to specific proteins on cancer cells. The modified CAR-T cells are then infused back into the patient, where they can target and kill cancer cells. 𝐓𝐮𝐦𝐨𝐫-𝐢𝐧𝐟𝐢𝐥𝐭𝐫𝐚𝐭𝐢𝐧𝐠 𝐥𝐲𝐦𝐩𝐡𝐨𝐜𝐲𝐭𝐞 (𝐓𝐈𝐋) 𝐭𝐡𝐞𝐫𝐚𝐩𝐲: This approach involves isolating immune cells, known as Tumor-infiltrating lymphocytes (TILs), from a patient's tumor. The TILs are then expanded and activated in the laboratory before being reinfused into the patient. 𝐃𝐨𝐰𝐧𝐥𝐨𝐚𝐝 𝐒𝐚𝐦𝐩𝐥𝐞 𝐏𝐚𝐠𝐞𝐬@ https://lnkd.in/gjZCzfWB 𝐌𝐨𝐧𝐨𝐜𝐥𝐨𝐧𝐚𝐥 𝐚𝐧𝐭𝐢𝐛𝐨𝐝𝐢𝐞𝐬: These are laboratory-produced #antibodies designed to target specific proteins on cancer cells. Monoclonal antibodies can work by directly attacking cancer cells, blocking growth signals, or triggering immune responses against cancer. Examples include drugs like rituximab (Rituxan), trastuzumab (Herceptin), and cetuximab (Erbitux). 𝐈𝐦𝐦𝐮𝐧𝐞 𝐬𝐲𝐬𝐭𝐞𝐦 𝐦𝐨𝐝𝐮𝐥𝐚𝐭𝐨𝐫𝐬: These #drugs aim to modulate the immune system to enhance its ability to recognize and attack cancer cells. They can include cytokines, such as interferons and interleukins, which help stimulate immune responses. Other #immunesystem modulators include immune stimulatory agents like talimogene laherparepvec (T-VEC), an oncolytic virus therapy. 𝐓𝐡𝐞𝐫𝐚𝐩𝐞𝐮𝐭𝐢𝐜 𝐯𝐚𝐜𝐜𝐢𝐧𝐞𝐬: These vaccines are designed to stimulate the immune system to recognize and attack cancer cells. Unlike preventive vaccines that aim to prevent #infections, therapeutic vaccines are used in patients who already have cancer. They can include tumor-specific antigens or whole #tumor cells, along with immune stimulants to enhance the immune response. Cancer Treatment Centers of America (acquired by City of Hope) Cancer Care Ontario | Action Cancer Ontario Cancer Grand Challenges #healthcare #antibiotics #cancertreatment #pharmaceutical #cancer #immunotherapies #cancerimmunotherapies #immunotherapy
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New DNA Origami Platform, DoriVac, Opens New Path for Designer Cancer Vaccine Development The central ingredient of therapeutic cancer vaccines is antigens, which are preferentially produced or newly produced (neoantigens) by tumor cells and enable a patient’s immune system to search and destroy the cancerous cells. In most cases, those antigens cannot act alone and need the help of adjuvant molecules that trigger a general alarm signal in antigen-presenting cells. Now, a research team has created a DNA origami platform—DoriVac—whose core component is a self-assembling square block-shaped nanostructure. To one face of the square block, defined numbers of adjuvant molecules can be attached in highly tunable, nanoprecise patterns, while the opposite face can bind tumor antigens. In a new study, DoriVac vaccines enabled tumor-bearing mice to better control the growth of tumors and to survive significantly longer than control mice. Importantly, the effects of DoriVac also synergized with those of immune checkpoint inhibitors, a highly successful immunotherapy already widely used in the clinic. The findings are published in Nature Nanotechnology, in the paper, “Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination.” “The DoriVac platform is our first example of how our pursuit of what we call Molecular Robotics—synthetic bioinspired molecules that have programmable shape and function—can lead to entirely new and powerful therapeutics,” said Wyss Institute founding director Donald Ingber, MD, PhD, who is also a professor of vascular biology at Harvard Medical School (HMS). “This technology opens an entirely new path for development of designer vaccines with properties tailored to meet specific clinical challenges. We hope to see its rapid translation into the clinic,” Ingber said. https://lnkd.in/eHMFRza2 Publication: https://lnkd.in/eQY-a3td
New DNA Origami Platform, DoriVac, Opens New Path for Designer Cancer Vaccine Development
genengnews.com
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🟨🟪 𝘾𝙖𝙣𝙘𝙚𝙧 𝙍𝙚𝙨𝙞𝙨𝙩𝙖𝙣𝙘𝙚 𝙩𝙤 𝙄𝙢𝙢𝙪𝙣𝙤𝙩𝙝𝙚𝙧𝙖𝙥𝙮: 𝘾𝙤𝙢𝙥𝙧𝙚𝙝𝙚𝙣𝙨𝙞𝙫𝙚 𝙄𝙣𝙨𝙞𝙜𝙝𝙩𝙨 𝙬𝙞𝙩𝙝 𝙁𝙪𝙩𝙪𝙧𝙚 𝙋𝙚𝙧𝙨𝙥𝙚𝙘𝙩𝙞𝙫𝙚𝙨 #MD_Immunol https://lnkd.in/dRxx3s25 🟣 There are several different types of immunotherapy, each with its own unique mechanism of action that as follows: 1️⃣ Types of work by activating T cells, a type of white blood cell that can recognize and kill cancer cells. 2️⃣ Blocking immune checkpoints, which are proteins on the surface of T cells that regulate the immune response. 👉🔷️ A type of immunotherapy that block the proteins on T cells that normally prevent them from attacking cancer cells. By blocking these proteins, checkpoint inhibitors can activate T cells and enhance the immune response against cancer cells. 3️⃣ CAR T-cell therapy. 🟣 Cancer immunotherapy has made substantial progress, but its effectiveness varies widely among patients. 🟣 Resistance to immunotherapy arises through multiple intrinsic and extrinsic mechanisms, resulting in primary, adaptive, and acquired forms of resistance 🟣 primary resistance” denotes a failure to respond to treatment from the start, and “secondary resistance” denotes a relapse following the initial response to immunotherapy. 🟣 Mechanisms of Resistance : ▶️ Intrinsic mechanisms involve 👉Alterations within cancer cells, such as 1️⃣ Defective antigen processing 2️⃣ presentation, dysfunctional interferon-gamma signaling, 3️⃣ upregulated immune checkpoints ▶️ Extrinsic mechanisms encompass the tumor microenvironment (TME) components, such as: 🔹️Immunosuppressive cells, 🔹️fibrotic stroma, 🔹️and hypoxia 🟣Types of Resistance : ▶️ Primary resistance occurs prior to treatment initiation and is independent of previous exposure to immunotherapy ▶️ Adaptive resistance emerges during treatment and is driven by selective pressure exerted by immunotherapy ▶️ Acquired resistance follows an initial response to immunotherapy and is typically linked to genetic changes occurring within cancer cells 🟣 Strategies to Overcome Resistance: ▶️ Recent approaches to combat resistance include: 👉🔹️ Priming T cells with vaccines to overcome acquired immune resistance 👉🔹️ Combining immunotherapy with targeted drugs, chemotherapy, radiation therapy, or epigenetic modifiers 👉🔹️ Engineering B cells for enhanced CAR-based immunotherapy 👉🔹️ Exploiting alternative immune checkpoints, such as LAG-3/FCRL6 engagement 👉🔹️ Manipulating the TME to promote a favorable immune environment. 🟣 It's noteworthy the effects of other external host factors cannot be ignored when considering resistance to immunotherapy. These factors can include patients’ age, sex, and overall health status, as well as lifestyle factors. 🟣 So further research should explore innovative combination therapies and novel targets to maximize the benefits of immunotherapy for cancer patients. #immunology #cancer #immunotherapy
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𝐄𝐱𝐩𝐥𝐨𝐫𝐢𝐧𝐠 𝐭𝐡𝐞 𝐅𝐮𝐭𝐮𝐫𝐞 𝐨𝐟 𝐂𝐚𝐧𝐜𝐞𝐫 𝐕𝐚𝐜𝐜𝐢𝐧𝐞𝐬 𝐌𝐚𝐫𝐤𝐞𝐭! 𝐆𝐞𝐭 𝐚 𝐅𝐑𝐄𝐄 𝐒𝐚𝐦𝐩𝐥𝐞: https://lnkd.in/dW4EejqU As we delve deeper into the realm of oncology, the spotlight shines brightly on the promising horizon of cancer vaccines. 𝐌𝐚𝐫𝐤𝐞𝐭 𝐎𝐯𝐞𝐫𝐯𝐢𝐞𝐰: The global cancer vaccines market is witnessing remarkable growth propelled by advancements in immunotherapy and personalized medicine. With an increasing emphasis on targeted therapies, the demand for cancer vaccines is soaring, poised to revolutionize cancer treatment paradigms. 𝐊𝐞𝐲 𝐈𝐧𝐬𝐢𝐠𝐡𝐭𝐬: 𝐓𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐀𝐝𝐯𝐚𝐧𝐜𝐞𝐦𝐞𝐧𝐭𝐬: Innovations in biotechnology and genetic engineering are driving the development of novel cancer vaccine platforms, offering tailored solutions for different cancer types. 𝐑𝐢𝐬𝐢𝐧𝐠 𝐈𝐧𝐜𝐢𝐝𝐞𝐧𝐜𝐞: The escalating burden of cancer worldwide underscores the urgent need for effective preventive and therapeutic interventions, positioning cancer vaccines as a pivotal tool in the fight against malignancies. 𝐈𝐦𝐦𝐮𝐧𝐨𝐭𝐡𝐞𝐫𝐚𝐩𝐲 𝐑𝐞𝐯𝐨𝐥𝐮𝐭𝐢𝐨𝐧: Cancer vaccines represent a cornerstone of immunotherapy, harnessing the body's immune system to recognize and eradicate cancer cells with precision, paving the way for more targeted and durable treatment outcomes. 𝐏𝐢𝐩𝐞𝐥𝐢𝐧𝐞 𝐏𝐫𝐨𝐠𝐫𝐞𝐬𝐬: Robust clinical pipelines are fueling optimism, with a myriad of cancer vaccine candidates undergoing rigorous evaluation across various stages of clinical trials, offering hope for patients and healthcare providers alike. 𝐌𝐚𝐫𝐤𝐞𝐭 𝐏𝐫𝐨𝐣𝐞𝐜𝐭𝐢𝐨𝐧𝐬: The cancer vaccines market is slated for exponential growth, with projections indicating a significant surge in market size in the coming years. Factors such as increasing research investments, favorable regulatory landscapes, and rising healthcare expenditures are poised to propel market expansion, aiming to reach unprecedented heights by 2030. 𝐅𝐮𝐭𝐮𝐫𝐞 𝐎𝐮𝐭𝐥𝐨𝐨𝐤: As we navigate the evolving landscape of cancer care, the advent of cancer vaccines holds immense promise in reshaping treatment strategies, fostering hope for improved patient outcomes, and ultimately, steering us closer to our collective goal of conquering cancer. 𝐕𝐚𝐫𝐢𝐨𝐮𝐬 𝐦𝐚𝐫𝐤𝐞𝐭 𝐩𝐥𝐚𝐲𝐞𝐫𝐬: GSK, UbiVac, Biontech, Dendreon, Dynavax Technologies, Imugene Limited, Moderna, and OXFORD VACMEDIX UK LIMITED. Let's join forces in advancing the frontier of cancer vaccines, ushering in a new era of hope and healing. Together, we can make strides towards a future where cancer is no longer a formidable foe but a conquerable challenge. #cancervaccines #oncology #immunotherapy #healthcareinnovation #marketresearch #markettrends #businessinsights
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