🧬 Advanced cell models such as 3D organoids offer accurate representations of human organs and are increasingly becoming a valuable tool for enhancing our understanding of healthy physiology and disease mechanisms. Labiotech.eu's latest report, sponsored by Sartorius examines the evolution, advantages, current applications, and future potential of 3D organoids. 🧪🔬 Download it today for a unique insight into the impact 3D organoids are having across oncology, neuroscience, immunology, and their potential in further advancing drug development: https://lnkd.in/gjcUY7Qr #organoids #researchtrends #cellmodels #drugdevelopment

Having an in vivo optical imaging system can help in research fields such as neuroscience, oncology, immunology among others. Let the images give you insight to your research! Book a demo of our optical imaging system: https://lnkd.in/gEYtevU2 #science #opticalImaging #Invivo #Exvivo #plantimaging #Demo #SystemDemo #Preclinical #Optical

Excited to share Scale Bio's latest application note showcasing our Single Cell RNA Sequencing Kit's performance across diverse tissue types. Our technology enables simultaneous profiling of brain, liver, lung, and kidney samples with remarkable results: 📊 468,000+ high-quality nuclei profiled in a single experiment 🧠 8-15 distinct cell populations identified per tissue 🔬 Rare cell types detected, including tissue-specific immune cells ⚡ Excellent performance even with debris-heavy samples Key takeaways: High-quality libraries from challenging tissue samples Exceptional cell recovery, preserving rare populations Superior sensitivity across multiple tissue types Streamlined workflow for efficient multi-sample processing Whether you're in neuroscience, oncology, or developmental biology, our solution can take your single cell research to the next level. Download the full application note: https://zurl.co/OdLx #SingleCellSequencing #RNAseq #Genomics #ResearchTools

Case study: Enabling 3D Multiplexing Spatial Omics Workflow Check out our newest case study to learn about 3D multiplexing spatial omics workflows, for gaining insights in Neuroscience, cancer research, immunology and single cell analysis. Explore detailed descriptions of 3D registration of spectral multiplexing data, AI object segmentation, and statistical analyses. https://lnkd.in/e4bbCupB

This case study provides a blueprint for the analysis of 3D spatial omics multiplexing datasets from a CODEX multiplex antibody panel imaged with a custom set-up using the Akoya Phenocycler and ZEISS LSM 980 confocal microscope to explore the expression of an extensive list of pre-synaptic markers in the mouse brain. A detailed description of 3D registration of spectral multiplexing data, AI object segmentation, and statistical analyses, including cell neighborhood and dimensionality reduction analyses, are provided. These can provide unique insights not only into neuroscience but also cancer research, immunology, and single-cell analysis experiments.

Our Exosome Antibody Sampler Kits have just launched! 🚀 Exosome isolation and analysis continues to be a powerful system for biomarker discovery and potential drug delivery for numerous diseases. Proteintech now offers cost-effective kits containing highly validated antibodies against key proteins for the characterization of exosomes. Each kit includes antibodies: ✅ Against key exosome proteins, such as CD63, Alix, TSG101, and HSP70; GM-130 as a negative control. ✅ Validated in multiple applications ✅ Validated in isolated exosomes ✅ Provided in 20μl vials – perfect for testing out multiple antibodies for new experiments with just one product! Learn more about our exosome antibody kits: https://ow.ly/Zh3u50SRzr5 #exosomes #antibodies #regenerativemedicine #cancer #neuroscience #organelles #westernblot #flowcytometry #biomarkers #biomarkerdiscovery

☑️ *READ ABSTRACT BELOW:* Keywords: 3D organoid model; EV; brain cancer; extracellular vesicle; glioblastoma multiforme; microRNA; proteomics. Part 1: Background: Newer 3D culturing approaches are a promising way to better mimic the in vivo tumor microenvironment and to study the interactions between the heterogeneous cell populations of glioblastoma multiforme. Like many other tumors, glioblastoma uses extracellular vesicles as an intercellular communication system to prepare surrounding tissue for invasive tumor growth. However, little is known about the effects of 3D culture on extracellular vesicles. The aim of this study was to comprehensively characterize extracellular vesicles in 3D organoid models and compare them to conventional 2D cell culture systems. Methods: Primary glioblastoma cells were cultured as 2D and 3D organoid models. Extracellular vesicles were obtained by precipitation and immunoaffinity, with the latter allowing targeted isolation of the CD9/CD63/CD81 vesicle subpopulation. Comprehensive vesicle characterization was performed and miRNA expression profiles were generated by smallRNA-sequencing. In silico analysis of differentially regulated miRNAs was performed to identify mRNA targets and corresponding signaling pathways. The tumor cell media and extracellular vesicle proteome were analyzed by high-resolution mass spectrometry.(...) Schuster M, Front Immunol. 2024 Apr 25;15:1388769. doi: 10.3389/fimmu.2024.1388769. PMID: 38726003; PMCID: PMC11079215. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum

Customize your proteomics biomarker analysis with SomaScan® Panels. Did you know you can design your own panel or select from a menu of disease-specific panels?   Panel design that’s fast, simple and cost-effective. You can: ·     Design your own 100 -1,500 protein analyte panels from our complete 11K Assay menu with no additional development cost or time ·     Choose from curated disease-specific panels for cancer, neurology, cardiology, cytokines and more ·     Achieve sensitive detection and reproducibility in plasma and serum   Ready to unlock new biological insights? Connect with a research expert. https://bit.ly/4dGF76X   Want to learn more? Visit our website. https://bit.ly/3JVyPmu   #BiomarkerDiscovery #ResearchInnovation #Somalogic #ProteinPanels #Proteomics

SomaScan Assay custom panel selection for 100 or 1500 targets with no development cost. There are very few platforms or assays which do not require development, so this is a game changer. Get in touch for a quote or to discuss a pilot study. #somascan #precisionmedicine #target #proteomics #nextgen #dontmissout

We are excited to introduce #interinstitutional postdoctoral researcher changgyun park! He is working with Christel Herold-Mende at Medical Faculty Heidelberg and Peter Lichter DKFZ Deutsches Krebsforschungszentrum on the drug responses in tumor organoids of brain metastases. "Breast cancer is the most commonly diagnosed cancer which can metastasize into other tissue, like the brain. I aim to improve the lives of breast cancer patients with brain metastases through the integrative analyses of personalized drug response and genomic data. The great support provided by the Alliance enables me to tackle this meaningful topic." More on the interinstitutional Postdoc Program: https://lnkd.in/eXBZJuMN #lifescience #research #lifesciences #gesundheit #lifesci #health #healthscience #medicalresearch #biochemistry #biomedicine #researchalliance #rheinneckarregion #Heidelberg #Mannheim #Innovation #academia #depression #exercise #uniheidelberg #zi_mannheim #cancer