Organ Recovery Systems’ Post

Acute liver failure (ALF) carries a mortality rate exceeding 40%. While orthotopic liver transplantation stands as the primary clinical recourse, its widespread adoption is hampered by donor scarcity and immunological rejection. This study initially delineates the etiologies and treatment parameters of ALF. It then provides a comprehensive overview of typical nanofiber scaffold fabrication techniques and their applications in modulating the function of liver-related cells and treating ALF. https://lnkd.in/gMxZjpwg #biomedical #tissueengineering

🗞️𝐀𝐥𝐥𝐨𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬 𝐡𝐚𝐬 𝐛𝐞𝐞𝐧 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐢𝐧 𝐇𝐚𝐧𝐝𝐞𝐥𝐬𝐛𝐥𝐚𝐭𝐭, 𝐨𝐧𝐞 𝐨𝐟 𝐆𝐞𝐫𝐦𝐚𝐧𝐲'𝐬 𝐥𝐞𝐚𝐝𝐢𝐧𝐠 𝐛𝐮𝐬𝐢𝐧𝐞𝐬𝐬 𝐧𝐞𝐰𝐬𝐩𝐚𝐩𝐞𝐫𝐬!🗞️ In the article, titled "𝘈𝘭𝘭𝘰𝘨𝘦𝘯𝘦𝘵𝘪𝘤𝘴: 𝘉𝘪𝘰𝘵𝘦𝘤𝘩 𝘊𝘰𝘮𝘱𝘢𝘯𝘺 𝘧𝘳𝘰𝘮 𝘏𝘢𝘯𝘯𝘰𝘷𝘦𝘳 𝘈𝘪𝘮𝘴 𝘵𝘰 𝘔𝘢𝘬𝘦 𝘋𝘰𝘯𝘰𝘳 𝘖𝘳𝘨𝘢𝘯𝘴 𝘐𝘯𝘷𝘪𝘴𝘪𝘣𝘭𝘦", our groundbreaking approach to organ transplantation is highlighted. Instead of relying on lifelong immunosuppression, our innovative technology creates immunological invisibility for donor organs, offering a promising new direction in transplantation medicine. 🔗 Read the full article here: https://lnkd.in/dejnwMEa The article highlights our innovative work in making organ transplantation safer and more effective. We're excited to continue advancing our mission and achieving new milestones.🎉 A big thank you to Handelsblatt for covering our story. Stay tuned for more updates as we continue to innovate and make a difference in the field of organ transplantation!🙏🏼 #Allogenetics #OrganTransplant #InvisibleOrgans #HealthcareInnovation #StartUpLife

#HOPEfortheWeek: Challenges With the Implementation of Machine Perfusion in Clinical Liver Transplantation    This article discusses the challenges in shifting from static to dynamic liver preservation in clinical practice; including organ perfusion strategies, ongoing trials, and future study design. It highlights the current research status, cost and regulatory impacts, along with factors for global implementation and reimbursement. The influence of research on cost-utility for tailored decision-making in perfusion strategies is also explored.    Femke de Goeij, Andrea Schlegel, et al.   https://lnkd.in/gdky486x #LiverTransplantation #MachinePerfusion  #HypothermicOxygenatedPerfusion #HOPEtreatment  #OrganTransplantation #ClinicalInnovation

Bridge to Life Announces Abstract Presentations at The European Society for Transplantation's ELITA Summit 2024 in Madrid, Spain, April 18-20, 2024: https://lnkd.in/g9B3Kz8d Abstracts to highlight #HOPE in liver #transplants and use in Extended Criteria Grafts

In an interview during CAHOCON 2024, Dr. Mohamed Rela provides a detailed overview of these groundbreaking developments that are transforming the field of liver transplant care as well as the innovative techniques he has introduced to improve patient outcomes and surgical success rates in liver transplantation. Watch his interview on Business World Healthcare for deeper insights. #cahocon24 #interview

Advancing Liver Transplantation 🩺 Exciting results show the potential of the #PerLife® system combined with #PerSorb® for ex-situ organ perfusion and purification for transplantation. Read more in our #PerTransplantationGallery https://bit.ly/3WzFEzT Another experience presented during the 2022 edition of the WPT: more insights on organ transplantation and organ perfusion will be addressed in the fourth edition of the 𝗪𝗼𝗿𝗸𝘀𝗵𝗼𝗽 𝗣𝘂𝗿𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗧𝗵𝗲𝗿𝗮𝗽𝗶𝗲𝘀 - 𝗙𝗿𝗼𝗺 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝘁𝗼 𝗖𝗹𝗶𝗻𝗶𝗰𝘀: '𝗧𝗵𝗲 𝗘𝗻𝗱 𝗼𝗳 𝗧𝗵𝗲 𝗕𝗲𝗴𝗶𝗻𝗻𝗶𝗻𝗴', taking place in Milan on September 26ᵗʰ and 27ᵗʰ, 2025. Share your experiences by sending your abstract to purification.therapies@aferetica.com. For more information, visit ⬇ https://bit.ly/3IiCnyG #Aferetica #Transplantation #Liver #OrganPerfusion #ScientificLiterature #CollaborativeResearch #WPT2025

Real-Time Mitochondrial Function Assessment for Organ Transplantation! A recent study, headed by Shannon Tessier, Harvard Medical School and Shriners Children's Hospital, introduces a novel, real-time, and non-invasive method to assess organ quality during machine perfusion. By focusing on mitochondrial function and injury using resonance Raman spectroscopy, this approach could revolutionize transplantation outcomes. In the study, the index of mitochondrial oxidation (3RMR) was used to compare acellular and cellular-based perfusates in cold ischemic rodent livers. After 24 hours of static cold storage, 3RMR returned to baseline faster with a cellular-based perfusate. However, 3RMR progressively increased during perfusion, indicating that injury may develop over time. This research highlights the need for further refinement of reoxygenation strategies during normothermic machine perfusion, considering cold ischemia durations, gradual recovery/rewarming, and hemolysis risk. 🔗 Read more: https://lnkd.in/d-v7W4H7. Stay tuned for #TargetingMitochondria2024 this October for more updates mitochondria and the future of organ transplantation. #WorldMitochondriaSociety #TargetingMitochondria2 #mitochondria #mitochondriaresearch #transplantation #organperfusion

What analysis do we do in the laboratory before organ transplantation? 🤔💭 #Medical_laboratories Answer : major histocompatibility complex MHC It divides ✔️MHC I It is found in all cells that contain a nucleus, so they call it HLA ✔️MHC II It is found in APC cells only to play a role in the process of activation and elimination of the foreign body, meaning only the cells that present Ag ‏✔️ABO system ✔️lymphocytosis

Analyzing Refusal Patterns of Donor Hearts: Insights for Transplantation In the ever-evolving landscape of organ transplantation, a recent study led by Tyler M. Dann, BS, sheds light on the refusal patterns of donor hearts, particularly those procured after circulatory death, offering valuable insights for the transplantation community. #Transplantation #HealthcareResearch #OrganDonation

https://lnkd.in/gQyE7PaH. New review: Cholangiocyte Organoids in Liver Transplantation; a Comprehensive Review. Congratulations to the authors: Carolina Rejas and PD Dr. med. Henrik Junger 'Liver transplantation is the only curative option for many liver diseases that end up in liver failure, and cholangiopathy remains a challenging complication post-liver transplant, associated with significant morbidity and potential graft loss. The low availability of organs and high demand for transplantation motivate scientists to find novel interventions. Organoids, as three-dimensional cell cultures derived from adult cells or induced pluripotent cells, may help to address this problem. Different types of organoids have been described, from which cholangiocyte organoids offer a high level of versatility and plasticity for a deeper study of liver disease mechanisms. Cholangiocytes can be obtained from different segments of the biliary tree and have shown a remarkable capacity to adapt to new environments, presenting an effective system for studying cholangiopathies. Studies using cholangiocyte organoids show promising results for disease modeling, where organoids offer fundamental features to recapitulate the complexities of tissues in vitro and uncover fundamental pathological pathways to potentially reveal therapeutic strategies for personalized medicine. #Organoids could hold the potential for regeneration of injured livers, representing tools of clinical impact in #regenerativemedicine when tissue damage is already present'.