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Molten salt students, industry, and colleagues... Please do not miss out on an excellent conference, The 2025 International Conference on Methods and Applications of Radioanalytical Chemistry (MARC). There are many sessions applicable to molten salt technologies (i.e. molten salt reactors, pyroprocessing, etc.). Check out session 5B (Radiochemistry of Molten Salt Reactors: Recent Progress, Methods and Applications) Organized by Derek Haas, Shayan Shahbazi, and myself! Abstract Deadline is December 1st #moltensalt #actinides #pyroprocessing

A new paper published! I am happy to share that our paper on the Influence of Diluent on Extraction Parameters of Systems for Separation Am(III) and Ln(III) Based on 1,10-Phenanthroline-2,9-Diamide was published today as a part of the Special Issue Advances in Coordination Chemistry 2.0 of Molecules MDPI! Big congratulations to the first author, Michail Gerasimov, and to everyone who contributed! Choosing the diluent is an important step in separation technology modeling. In this systematic study of extraction systems for f-element separation, the nature of the diluent is demonstrated to have a significant impact on the complex formation and extraction parameters of tetradentate N,O-donor diamide of 1,10-phenanthroline-2,9-dicarboxylic acid with Am(III) and Ln(III). Find out more about pros and cons of using different solvents for An(III)/Ln(III) separation in the paper!

I'm excited to share that our latest article titled "Synergic Catalysis: the Importance of Intermetallic Separation in Co(III)K(I) Catalysts for Ring Opening Copolymerizations" is online now in #JACS If you're interested in structure-activity relationships in heterodinuclear ROCOP catalysts make sure to give it a read! https://lnkd.in/ed2XNugA

Extracting #ions from water is crucial for several applications ranging all the way from #mining and #nuclear fuel cycling to #wastewater treatment and #environmentalremediation. Because much focus in the area has been typically set on developing selective #extractants for cations, the removal of anions from water tends to rely on their intrinsic properties (e.g., size and charge density). This limits the options for anyone interested in removing small and highly hydrated anions from aqueous systems. An important advancement in this regard is the recent development of novel rigid tweezer receptors with shapes complementary to target anions as described in the article by #SCGSR awardee Hazel Fargher in collaboration with Profs. Michael Haley and Darren Johnson of the University of Oregon, and Drs. Laetitia Delmau, Vyacheslav Bryantsev, and Bruce Moyer of Oak Ridge National Laboratory. Read more about these novel extractants at https://lnkd.in/embSHAYM And remember: applications for the 2024 SCGSR awards are open! Submission deadline: May 1, 2024. If you are a #PhDstudent: apply now and contribute to pushing the boundaries of science. If you know a PhD student who may be interested in conducting part of their thesis research at a #DOE National Lab, please tell them to check out the SCGSR program at: https://lnkd.in/eKDGfTA

Faulted Chemistry in Flow Restricted Areas - A Potential Material Killer - Online Education Course Unintended water chemistry transients/intrusions in Nuclear Power Plants (NPPs), though not common, can occur periodically during power operation. Consequently, damage to plant materials and components, and the radiological impact to the plant can result in severe economic impact to the plant owners, regardless of whether it is a BWR, PWR or VVER. The methods adopted to overcome the impact of transients are not very different for plant type, subject to the specific guidelines that need to be adhered to depending on the type of NPP because of the different water chemistries used in BWRs, PWRs and VVERs. For more information about this course please click on the link below: https://lnkd.in/ehtmRkPU Please get back to me at: liam.strand@antinternational.com if you are interested in this product and/or if you have any questions. #nuclearsafety #nuclear #nucleareducation #onlineeducation   #antinternational

This article describes a remarkable capability. The innovations developed by the Karsa team are truly impressive. Together with our customers, we are addressing real challenges in mass spectrometry. Be first to hear about Multi-Pressure Chemical Ionization (MPCI) updates by following Karsa!

https://lnkd.in/gYY28Q-K This study presents the development of a scalable continuous flow process for synthesizing a densely functionalized quinazoline organozinc intermediate for the KRAS G12C inhibitor Divarasib (GDC-6036). Initially, a cryogenic batch metalation process faced logistical challenges due to the instability of the quinazoline organomagnesium species above −60 °C. Investigation of reaction kinetics in batch mode, followed by process modelling, led to a practical, continuous flow approach. Addressing reactor fouling issues, a combination of plug flow and continuous stirred tank reactors was implemented in the final production system. Laboratory experiments successfully translated to a multikilogram scale, yielding excellent performance in subsequent atroposelective Negishi cross-coupling.

New capabilities of MION2-Orbitrap Exploris system demonstrated Recently, our team developed a novel method for operating the #MION2 Orbitrap Exploris™ system, enabling highly sensitive analysis of a wide range of chemicals in complex gas mixtures, such as ambient air. This approach uses high-pressure adduct-forming chemical ionization for detecting polar, more functionalized compounds, and low-pressure chemical ionization for less functionalized, weakly polar compounds, all in one system. In the pre-print published on #ChemRxiv, our scientists and engineers, together with our academic collaborators, introduce and demonstrate the concept of Multi-Pressure Chemical Ionization (MPCI). This method combines capabilities that currently require multiple mass spectrometry systems. Follow Karsa to be the first to receive updates about MPCI! https://lnkd.in/dSAAvifz #ChemicalAnalysis #MassSpectrometry #massspec  #MION2 #OrbitrapExploris #ChemicalIonization #MultiPressureCI #ScientificResearch #AnalyticalChemistry #ResearchBreakthrough #GasMixtureAnalysis

The combined effort of our #TeamSolenis experts in Antwerp, Mönchengladbach and Wilmington, together with the NMR department of the University of Delaware, has led to the publication of an article in the esteemed journal of American Chemical Society Analytical Chemistry: https://lnkd.in/ge7Fj33R 📜 🔬 Our article addresses the need for more robust and/or complementing analytical techniques on PFAS (perfluoroalkyl substances) in consumer and food packaging materials. 📦 Current methods can over- or underestimate the levels of PFAS detected and therefore can exclude possible alternatives on the market, or worse: allow PFAS containing packaging on the market without being fully detected. 😱 🙅♂️ By using Fluorine-19 Solid-State Nuclear Magnetic Resonance Spectroscopy, we can differentiate signals of distinctive fluorinated sources without the need of sample clean up and therefore provide direct evidence of the presence or absence of PFAS. 🔎🕵♂️ Thanks to Solenis for giving me the opportunity of exploring the science behind this business case further and to write this article about it. A big thanks to my co-authors Ernie Laletas, Caitlin Quinn, Subbu V Raguraman, Patric Bierganns and Brian Carr for their contributions in every way possible. 🙏 🙏 🙏 #paper #packaging #foodpackaging #burgerwrap #barriercoating #consumerpackaging #PFAS #Solenis #UDel #TOF #NMR #ACS #analyticalchemistry

I'm thrilled to share my co-first-author paper with Advait Hasabnis in the Journal of the American Chemical Society where we introduce the notion of amplifying chemical shift sensitivity of fluorine #NMR protein tags by linking the #19F reporter to a dynamic tautomeric species! We were puzzled as to why the current paradigm in NMR tag design still relies solely on the intrinsic sensitivity of the nucleus while fluorescent probes for optical spectroscopy have undergone extensive rational design to modulate their photophysical properties and limit undesired energy transfer mechanisms. We envisaged it might be possible to amplify the chemical shift response to changes in protein conformation by embedding the 19F reporter within 2-pyridone, a tautomeric molecule which *itself* changes between lactam to lactim states in response to the polarity of its environment. We identified fluorinated pyridone tautomers that exhibited up to three-fold improvements in chemical shift sensitivity relative to our previous best-in-class protein NMR tag. In protein NMR applications, we found that labeling the alpha subunit of the stimulatory G protein as well as human serum albumin enabled us to delineate more functional states in the proteins' conformational ensembles that were unresolved by BTFMA! At its core, our paper is a manifesto on the concept of a molecular "amplifier" in the design of NMR tags. We believe that there are alternative tautomer-based chemical shift amplifiers that could be used for 19F NMR. The ideal tautomer must 1) have well-defined chemical shift signatures for each tautomeric state, and 2) should undergo fast tautomerism. In addition to prototropic tautomers such as 2-pyridone, valence tautomerization is another opportunity that could be explored. For example, benzene oxide and oxepin undergo rapid valence tautomerism where the benzene oxide component is favored in polar solvents. This was a long road filled with major challenges and hypothesis changes, and I'm so grateful for my talented colleagues in the Scott Prosser lab in organic chemistry, molecular biology, NMR spectroscopy, and computational chemistry as well as support from my co-supervisor Patrick Gunning and our collaborators Oleksandr Voznyy and Ernani Basso. This work would bever have been possible without their effort! https://lnkd.in/gbTCsTZz