Pia Nyeng’s Post

Parkinson's disease (PD) affects over 10 million people worldwide and costs nearly $25 billion annually in the United States alone. This progressive disorder, caused by the degeneration of dopamine-producing cells in the brain, has both genetic and environmental contributors, with recent studies even implicating the gut microbiome. The Michael J. Fox Foundation for Parkinson's Research and Taconic Biosciences are committed to advancing research to develop better therapies. Today, we are excited to introduce the Floxed Parkin mouse, a new model to accelerate Parkinson’s research and improve patient outcomes. Learn more: https://bit.ly/4bOeIBZ

Neurons malfunctioning in Parkinson's disease (PD) are often riddled with clumps of a protein called α-synuclein. But how exactly does this protein aggregation disrupt cellular health? The recently published research in Molecular Brain (co-authored by Shilpi Chaurasia from Excelra) sheds light on this critical aspect of PD progression. Discover: ➡️The Link Between α-synuclein and Cellular Chaos: Delve into how α-synuclein aggregation disrupts vital processes within neurons. ➡️A Deep Dive into Cellular Proteomics: Analyze protein changes in a PD mouse model using advanced techniques, revealing major shifts linked to α-synuclein. ➡️Unveiling the Body's Protein Management System: Explore how the body responds to α-synuclein misfolding, potentially identifying new therapeutic targets. ➡️Hope for New Treatments: Understanding α-synuclein's impact on cellular protein management opens doors for novel PD therapies! Download the full publication for a deeper dive into this exciting research: https://lnkd.in/gzQpXiwz #ParkinsonsDisease #Excelra #Proteostasis #Neuroscience #Research #Proteomics Shilpi Chaurasia, PhD Chandra Sekhar Pedamallu Uzma Saeed Puneet Saxena Amar Thyagarajan, PhD Maarten Braspenning Jan Ghyssaert

Precise pathways of microbiome-gut-brain axis communication have been a "black box" although grossly we know immune and neuroendocrine mediators are involved. This new paper by Bercik-Collins lab McMaster University Department of Medicine in collaboration with Universität Bern, University of Calgary, CAMH, CONICET La Plata, identifies a precise innate immune signalling mechanism by which initial gut colonization triggers normalization of behaviour in mice. The pathway opens the potential for therapeutic modulation along the microbiome- gut-brain axis and conditions associated with its dysfunction. https://lnkd.in/geztX5Hj

🧠 Mitochondria are central to the development of neurodegenerative diseases. Researchers from both industry and academia are diligently exploring pharmacological interventions aimed at enhancing mitochondrial function to combat these disorders. Key strategies include: boosting metabolic status, restoring mitochondrial depolarization, reducing oxidative stress, promoting mitochondrial biogenesis and more. 👉 Curious about the science behind these strategies? Do you want to learn how to measure mitochondrial parameters in in-vitro models accurately? 🔎 Read my blog to explore the crucial relationship between mitochondria and neurodegenerative diseases (link below) and follow Sygnature Discovery for more information. https://lnkd.in/dqnen-Bn

The inducible overexpression of the transcription factor Neurogenin 2 (NGN2) has proven to be an extremely useful tool in neurodegenerative disease research. Using the inducible NGN2 approach, neurons can be generated in just 14 days in vitro, expediting research in neurodegenerative disease. The team at Bioneer are happy once again to have collaborated with the group of Prof. Kristine Freude at the University of Copenhagen to help generate a series of inducible NGN2 iPSC lines for an allelic series of Huntington's Disease iPSCs, to help expedite Huntington's Disease Research (article below). If you are interested in knowing more about how Bioneer can help make inducible NGN2 iPSC lines to assist you research, please reach out to Dale Shelton for more details. #NGN2 #Huntingtonsdisease #Huntingtons #iPSC https://lnkd.in/d-VjXCqf

📌An unexpected lung function: Your lungs also make blood Research has shown that lungs do more than help us breathe—they also play an important role in blood production. As a cornerstone, scientists have found that rat lungs produce more than 10 million platelets per hour, accounting for the majority of platelets in the animals' bloodstream. This discovery challenges the long-held belief that all blood components are made only by bone marrow. Researchers at the University of California, San Francisco have identified a previously unknown pool of blood stem cells in the lungs. These cells, originally thought to inhabit the bone marrow, are now seen as major players in blood formation. "This finding changes our understanding of the lungs, showing that they are important not only for breathing, but also for blood production," said researcher Mark R. Looney. The discovery was made using advanced two-photon imaging, which allowed the team to track fluorescently labeled platelets as they moved through the lungs. This research opens new doors to understanding blood production and its potential implications for human health Stay connected and Updated With DOCTOR OF PHARMACY ASSOCIATION (W.B) 🔗Facebook - https://lnkd.in/gPRNiWKu 🔗 Linkdin - https://lnkd.in/gd3zcFpe 🎓 Important for Pharm D students and Professionals community: https://lnkd.in/gEZXtnna

TransBIOTech pushes the boundaries of science to fight against neurodegenerative diseases. 🧠 There is still no effective treatment for neurodegenerative diseases, and their incidence is increasing dramatically as populations age. To study the mechanisms involved and develop effective therapeutic approaches, researchers need to use relevant models that represent the complexity of the human #brain. Thanks to support from the Ministère de l'Éducation du Québec (MEQ)'s Programme d'Aide à la Recherche et au Transfert (PART), we are working on the creation of cerebral #assembloids. These innovative structures combine the advantages of #organoids with other cell types (blood cells, immune cells, microglia, etc.) to reproduce the interactions between different cell types. Currently, our researchers are developing an assembloid to model #Parkinson's disease. Contact us to find out more about our innovative models!

Check out the latest IPN paper in J. Med. Chem. on the development of psychoplastogenic DYRK1A inhibitors with potential for treating Alzheimer's disease especially early-onset Alzheimer's disease associated with Down Syndrome https://lnkd.in/gcZ6rjNT.

I really enjoyed the great work presented and the lively discussions at the 5th European B-cell network (EBCnet) meeting in Egmond aan Zee. Many thanks to the organizers Rudi Hendriks and Stijn Vanhee for making this event possible. Personally a lot of eye openers to further dive into the role of B cells in people with #MultipleSclerosis. One of our aims is to elucidate how pathogenic B cells are shaped by factors such as genetic variants and #EBV in MS, and how this overlaps with and differs from other chronic inflammatory and autoimmune diseases. Together with the lessons we learn from (single cell) analyses at different disease stages, in different compartments and after different treatments, this can be used to find new ways to only target B cells that accumulate and are detrimental in the MS brain. Erasmus MC - MS Center ErasMS Stichting MS Research Nationaal MS Fonds #BEHINDMS #HORIZONEU

📃Scientific paper: Roles of NG2 Glia in Cerebral Small Vessel Disease Abstract: Cerebral small vessel disease (CSVD) is one of the most prevalent pathologic processes affecting 5% of people over 50 years of age and contributing to 45% of dementia cases. Increasing evidence has demonstrated the pathological roles of chronic hypoperfusion, impaired cerebral vascular reactivity, and leakage of the blood–brain barrier in CSVD. However, the pathogenesis of CSVD remains elusive thus far, and no radical treatment has been developed. NG2 glia, also known as oligodendrocyte precursor cells, are the fourth type of glial cell in addition to astrocytes, microglia, and oligodendrocytes in the mammalian central nervous system. Many novel functions for NG2 glia in physiological and pathological states have recently been revealed. In this review, we discuss the role of NG2 glia in CSVD and the underlying mechanisms. Continued on ES/IODE ➡️ https://etcse.fr/He81V ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.