Taconic Biosciences’ Post

Progress in translational research has been impeded by a lack of highly multiplexed and ultrasensitive proteomic technologies. #NULISA is addressing this challenge and changing the way we profile proteins from biofluids. Stop by our poster this week at Keystone Symposia's meeting on Neurodegenerative Diseases in Santa Fe, NM. Meet with Douglas Hinerfeld and Max Mahoney learn more! https://ow.ly/bW5O50S6rgx #KSNeurodegen24

Pleased to share that our review on "Innervation of the pancreas in development and disease" is out now. In this review we provide an overview of recent progress in mapping pancreatic innervation and understanding the interactions between pancreatic neurons, epithelial morphogenesis and cell differentiation. https://lnkd.in/d7sBufSZ

"Final Reminder: Longevity Conference Registration Closes Soon – Your Last Chance to Join!" 📢 09 days to go!!! Register here: https://lnkd.in/gYHYutNs Global Longevity Federation Conference 2024! Date: March 25-26, 2024 Event site: https://lnkd.in/gac_k83s HGPS is a rare disease characterized by premature aging, with limited effective and safe medical interventions due to incomplete understanding of its cellular aging mechanisms. Using patient-derived cells and mouse models, we demonstrate that mitophagy defects drive aging-related phenotypes in HGPS by activating the STING-NF-ĸB pathway and the senescence-associated secretory phenotype (SASP). Furthermore, scientists show that mitophagy induction ameliorates aging-associated phenotypes of HGPS and natural aging mice, indicating that mitophagy is a potential therapeutic target for both HGPS and aging. Image Credits: Aging Cell, Wiley

Proteins fluctuate throughout our lives and are often the first telltale signs of changes to human health, but proteins are not the only indicators of disease. Small, complex carbohydrate groups called glycans that attach to proteins and assist in protein stability, solubility, and foldability also change. Join Yehia Mechref from Texas Tech University on March 21 at 1:00PM ET to learn how to detect subtle changes to glycoproteins that may predict neurodegenerative disease and traumatic brain injury outcomes. Register today: https://ow.ly/lSiW50QGRln

Proteins fluctuate throughout our lives and are often the first telltale signs of changes to human health, but proteins are not the only indicators of disease. Small, complex carbohydrate groups called glycans that attach to proteins and assist in protein stability, solubility, and foldability also change. Join Yehia Mechref from Texas Tech University on March 21 at 1:00PM ET to learn how to detect subtle changes to glycoproteins that may predict neurodegenerative disease and traumatic brain injury outcomes. Register today: https://ow.ly/iSsL50QGR8C

🔬 Lab Update! 🔬 We're using our MI-SIM super-resolution microscope to track autophagy in lysosomes and mitochondria, revealing new details about cellular health and disease mechanisms. Make sure you click ‘follow’ to stay up to date with all the latest from us! #CellBiology #SuperResolutionMicroscopy #Mitophagy #Autophagy #ScientificResearch

Very interesting Nature article by Amber Dance. 👏👏👏 I’d love 😍 to see cell classification by biological systems (e.g., the cardiovascular system) and their cell functions. According to the article, this would likely be categorized by cell function and response to the environment. https://lnkd.in/eiH5eZXE

Misfolded protein aggregates are a hallmark of neurodegenerative conditions like Alzheimer's, Parkinson's, ALS, and Huntington's disease, creating toxic environments that drive disease progression. For example, Alzheimer's disease is marked by β-amyloid plaques and tau tangles that disrupt brain function, while Parkinson's disease features α-synuclein aggregates known as Lewy bodies. Understanding these protein aggregates is crucial for developing effective treatments for these challenging conditions. The blog explores a new spatial proteomics discovery technique that enables researchers to pinpoint the exact location and composition of protein aggregates within diseased tissues. Read more - https://lnkd.in/gEjdyz6E

📰 We are thrilled to highlight that our #breakthrough in Parkinson's diagnostics was featured in Parkinson's News Today. "This discovery marks a monumental step forward in our understanding and ability to diagnose this challenging condition." wrote Margarida Maia, PhD in the article. Read the article on Parkinson's News Today here https://lnkd.in/gJsC93Dc BPGbio's ParkinsonDx is another product of our NAi Interrogative Biology Platform in identifying a biomarker for disease diagnosis. How does our platform work? Read here: https://lnkd.in/gvTXPEEf For BD inquires, email BD@bpgbio.com #ParkinsonsDisease #EarlyDetection #Biomarkers #MedicalResearch #HealthcareInnovation #BPGbio #NeurodegenerativeDiseases #PatientCare #diagnostics #AIdrugdiscovery #AIplatform

ALS research has seen many exciting updates this year! The biggest came just two months ago, when researchers identified the genes connected to brain cell loss in the disease. Findings like this will have a massive ripple effect on other neuromuscular diseases like SMA, which is why supporting brain research is so important. Read about all the latest research updates and progress in the ALS field here: https://lnkd.in/gN3BC9Yn