PsychoGenics’ Post

Mitochondrial dysfunction is very implicated in neuropsychiatric disorders. Therefore, understanding hemodynamic-metabolic decoupling with human in vivo optical neuroimaging techniques is essential. See what we say about this ⤵ https://lnkd.in/dyT2BPnp

We're entering a renaissance in neuropsychiatry as we continue learning more about the brain and its workings. Highlights in this month's Quill Quartet include a big approval for schizophrenia, single-cell characterization in neurodegenerative diseases (Alzheimer's, frontotemporal dementia, and supranuclear palsy), new protocols to speed up non-pharmacologic interventions, and investments in new mechanisms of action for investigational drugs to treat severe mental illness. Read more: ❇️ Approval of Cobenfy (KarXT): https://buff.ly/4gGuvqk ❇️ Cross-disorder and disease-specific pathways in dementia: https://buff.ly/3UcxQUk ❇️ New transcranial magnetic stimulation protocol tested: https://buff.ly/4cPESWx ❇️ Biopharma investing in new MOAs: https://buff.ly/4cSJydc And check us out at buff.ly/3RRt4cQ! Do you find the Quill Quartet useful? We will be rolling this into a monthly newsletter soon and would love to know if you'd like this kind of content coming directly to your inbox instead of (or in addition to) possibly appearing in your feed. Let us know! 🙋♂️

Brain Acidity Linked With Multiple Neurological Disorders https://lnkd.in/eqN_Dtkc

Check out this new paper published by Evan Lewis. A very exciting read!

Psychogenic non-epileptic seizures (PNES) can be exacerbated by the psychological burden of epilepsy. This case report highlights a 19-year-old female with PNES and focal epilepsy, worsened by anxiety from her diagnosis. Read more: https://bit.ly/47gq29w #MentalHealth #Neurology

My other hat aside from chronic pain is dystonia and functional neurological disorder (FND). There are many similarities between chronic pain and these movement disorders. Moving to a broader model, away from the reductionist biomedical model is a vital step forward. I believe in the whole person approach. This means seeing the person in their lived world and not separating the two. It means seeing a person who has strengths, capabilities, and autonomy. They are the expert in themselves. A body of work is building in support of this approach, despite the common sense of it! For the link to this paper, see comments. Abstract: Stress is a well-known risk factor to develop a functional neurological disorder, a frequent neuropsychiatric medical condition in which patients experience a variety of disabling neurological symptoms. Only little is known about biological stress regulation, and how it interacts with predisposing biological and psychosocial risk factors. Dysregulation of the hypothalamic–pituitary–adrenal axis in patients with functional neurological disorders has been postulated, but its relationship to preceding psychological trauma and brain anatomical changes remains to be elucidated. We set out to study the hypothalamic–pituitary–adrenal axis analysing the cortisol awakening response and diurnal baseline cortisol in 86 patients with mixed functional neurological symptoms compared to 76 healthy controls. We then examined the association between cortisol regulation and the severity and duration of traumatic life events. Finally, we analysed volumetric brain alterations in brain regions particularly sensitive to psychosocial stress, acting on the assumption of the neurotoxic effect of prolonged cortisol exposure. If you have a client diagnosed with FND and you want to arrange care and personalised rehabilitation, please get in touch. #thepaincoach #chronicpain #FND #neurology #casemanager

Epilepsy is a neurological disorder characterized by recurrent seizures, which are sudden, uncontrolled electrical disturbances in the brain. These seizures can vary widely in intensity and duration. While the exact cause of epilepsy isn't always clear, some common factors include: Genetics: Certain genetic factors can predispose individuals to epilepsy. Brain Injury: Traumatic brain injuries, strokes, tumors, and infections can disrupt normal brain function and lead to epilepsy. Developmental Disorders: Conditions such as autism and neurodevelopmental disorders can increase the risk of epilepsy. Infections: Certain infections like meningitis or encephalitis can cause brain damage and trigger epilepsy. Treatment for epilepsy often involves a combination of medications, lifestyle modifications, and in some cases, surgery. The primary goals of treatment are to control seizures, minimize side effects, and improve quality of life. Common treatment options include: -Antiepileptic Drugs (AEDs): Medications are the most common form of treatment and work by stabilizing electrical activity in the brain. -Ketogenic Diet: A high-fat, low-carbohydrate diet that has been shown to reduce seizures in some individuals, particularly children. -Vagus Nerve Stimulation (VNS): A surgical procedure that involves implanting a device that stimulates the vagus nerve to reduce seizure activity. -Surgery: In cases where seizures originate from a specific area of the brain that can be safely removed, surgery may be considered to reduce seizure frequency or severity. # #epilepsy #epilepsyawareness #ketogenicdiet #epilepsycure #healthylifestyle #ask_daisy #noureesh #viralreels #trending #healtheducation #wellbeing #braindisorders #seizures

Looking forward to participating in this panel + talking about all things gut-brain-axis, and how microbes may hold many answers for our health.

"Kainate receptors (KARs) are members of the ionotropic glutamate receptor family of tetrameric ion channels. Postsynaptic KARs mediate excitatory #Neurotransmission in the central nervous system (#CNS) whereas presynaptic KARs act as #Neuromodulators by tuning the secretion of excitatory and inhibitory neurotransmitters. KARs regulate the development and maturation of neuronal connections and are involved in memory formation. They are implicated in neurodevelopmental, #Neurodegenerative and psychiatric disorders, including #Pain, #Epilepsy, #Migraine, #HuntingtonsDisease, #Schizophrenia, #DownSyndrome, #Depression, and bipolar, #Autism spectrum and obsessive-compulsive disorders, therefore representing an important #DrugTarget for therapeutic development!" Do not miss this amazing open-access article published in Nature Portfolio yesterday, in which Sobolevsky Alexander and colleagues from Columbia University applied time-resolved #CryoEM to reveal structures of of the kainate receptor GluK2 in the presence of the #Agonist glutamate and the positive allosteric modulators (PAMs) lectin concanavalin A and BPAM344: https://lnkd.in/etfiqf_X Concanavalin A and BPAM344 inhibit kainate #Receptor desensitization and prolong activation by acting as a spacer between the amino-terminal and ligand-binding domains and a stabilizer of the ligand-binding domain dimer interface, respectively, and secondly, channel opening involves the kinking of all four pore-forming M3 helices! These structures reveal the #MechanismOfAction (MoA) of kainate receptor gating and function, which will guide #DrugDesign and #DrugDevelopment for treatment of neurological disorders! #CryoEM #Neurology #DrugDiscovery

Low intensity light to fight the effects of chronic stress https://lnkd.in/dBhSFT8i Some neurological disorders can be improved through photobiomodulation, a non-invasive technique based on the application of low-intensity light to stimulate altered functions in specific regions of the body. Now, a study reveals how photobiomodulation applied to the brain-gut axis is effective in recovering some cognitive alterations and sequelae caused by chronic stress. The study opens up new perspectives for applying the technique in future therapies for the treatment of neurological diseases in patients.