Publishing House of Neural Regeneration Research’s Post

Paul Hyslop, from ARKLEY BIOTEK LLC Indianapolis, details an ongoing specific research approach to identify, characterize, and validate physiologically relevant neuronal targets of #H2O2 in designing therapeutics for #neurodegenerative disease progression The societal impact of #dementia resulting from the major neurodegenerative diseases such as #Alzheimer’s presents a growing and significant unmet medical need. (1) Various cellular #metabolic and structural deficits, neuroinflammation, and oxidative stress are known to result in the progressive loss of vulnerable non-regenerative #neurons. (2) Find out more here: https://bit.ly/3SZPklr

Background: Parkinson disease (PD) is a prevalent neurodegenerative disorder affecting dopaminergic neurons in the substantia nigra (SN). Neuroinflammation has a vital role in PD pathophysiology. Objectives: This study assesses whether the neuroinflammatory molecular and signaling pathways could be associated with PD’s progression and clinical manifestations. Materials & Methods: PubMed, Web of Science, Embase, and Scopus databases were investigated from 2006 until December 2023 to find relevant studies. All observational studies written in English and reporting qualitative or quantitative information on the relationship between neuroinflammation and PD were included in this review. Results: Finally, 41 papers were involved in the systematic review. According to the involved studies, it is suggested that tumor necrosis factor-α, C-reactive protein, microsomal prostaglandin E synthase1, toll-like receptor-4 (TLR-4), CCL23, CCL25, TNF-receptor superfamily member 9, EV-derived cytokines, transforming growth factor alpha, vascular endothelial growth factor A, SH-SY5Y, TLR 2/4, miR-485-3p, leucine-rich repeat kinase 2, and α-synuclein may be upregulated in the PD patients. Also, the activity of astrocytes and microglial cells was reported to be increased in PD patients through different mechanisms.  Conclusion: This study demonstrated that the neurodegeneration in PD could be initiated by α-synuclein protein aggregation and the activation of astrocytes and microglial cells, which leads to neuroinflammation characterized by inflammatory responses in neurons. Finally, chronic neuroinflammation could be the cause of dopaminergic neuronal death in SN. The impact of both single and all factors involved in neuroinflammation was assessed to plan further studies in a particular pathway to intercept the onset of inflammatory pathways in favor of therapeutic purposes.    #CReactiveProtein #TumorNecrosisFactorα, #αSynuclein, #TollLikeReceptor2, #TLR9

🚨 New Review on CDK5 as a Therapeutic Target in Alzheimer's Disease 🧠 I'm excited to share our latest publication, where we dive deep into the critical role of Cyclin-Dependent Kinase 5 (CDK5) in the pathogenesis of Alzheimer's Disease (AD). With neurodegenerative disorders like AD on the rise, effective treatments are more important than ever. In this review, we explore: 🔸The normal functions of CDK5 in brain development and memory formation. 🔸How dysregulation of CDK5, specifically through hyperactivation by the p25 protein, contributes to Alzheimer's progression. 🔸The potential of targeting CDK5 for future therapeutic interventions, including small-molecule inhibitors and peptide therapies. With its involvement in both amyloid-beta and tau protein abnormalities, CDK5 represents a promising avenue for therapeutic innovation in AD. Our paper synthesizes the latest research, offering new insights for developing treatments that could halt or slow disease progression. Read more to understand how targeting CDK5 could change the future of Alzheimer's treatment! 💡 #AlzheimersResearch #Neurodegeneration #CDK5 #Therapeutics #MedicalInnovation Link: https://lnkd.in/eSsC3HVe

📃Scientific paper: T‐type calcium channels as therapeutic targets in essential tremor and Parkinson's disease Abstract: Neuronal action potential firing patterns are key components of healthy brain function. Importantly, restoring dysregulated neuronal firing patterns has the potential to be a promising strategy in the development of novel therapeutics for disorders of the central nervous system. Here, we review the pathophysiology of essential tremor and Parkinson's disease, the two most common movement disorders, with a focus on mechanisms underlying the genesis of abnormal firing patterns in the implicated neural circuits. Aberrant burst firing of neurons in the cerebello‐thalamo‐cortical and basal ganglia‐thalamo‐cortical circuits contribute to the clinical symptoms of essential tremor and Parkinson's disease, respectively, and T‐type calcium channels play a key role in regulating this activity in both the disorders. Accordingly, modulating T‐type calcium channel activity has received attention as a potentially promising therapeutic approach to normalize abnormal burst firing in these diseases. In this review, we explore the evidence supporting the theory that T‐type calcium channel blockers can ameliorate the pathophysiologic mechanisms underlying essential tremor and Parkinson's disease, furthering the case for clinical investigation of these compounds. We conclude with key considerations for future investigational efforts, providing a critical framework for the development of much needed agents capable of targeting the dysfunctional circuitry underlying movement disorders such a... Continued on ES/IODE ➡️ https://etcse.fr/8xoN ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

🎉 Congratulations to Professor Jin-Tai Yu! His latest research, published in "CNS Neuroscience & Therapeutics," achieves significant advancements in the diagnosis and prognosis of Rapidly Progressive Dementia (RPDs) using AstraBio's SMID technology. This study introduces a novel perspective by utilizing a combination of biomarkers based on the ATN framework to establish early identification and treatment response in RPDs. 🌟 #DementiaResearch #SMIDTechnology #AstraBio

🔬 A groundbreaking study by Chuan Qin et al. sheds light on the potential of CAR-T cell therapy in treating neurological autoimmune diseases like neuromyelitis optica spectrum disorder (NMOSD). Their single-cell multi-omics analysis of patients undergoing anti-BCMA CAR T cell treatment revealed fascinating insights into CAR T cell kinetics, function, and immune alterations in the central nervous system. Key findings include the identification of cytotoxic-like CD8+ CAR T cell clones as main effectors in autoimmunity, enhanced chemotaxis of CAR T cells across the blood-CSF barrier, and the suppression of neuroinflammation. Additionally, the study highlighted the distinctive features of CAR T cells in patients with NMOSD compared to those with hematological malignancies, paving the way for optimized immunotherapies for autoimmune disorders. This research not only deepens our understanding of CAR T cell therapy but also offers promising avenues for the future treatment of autoimmune diseases. Kudos to the team for their valuable contributions to advancing precision medicine! 🌟💉🧠 #Immunotherapy #AutoimmuneDiseases #PrecisionMedicine 🧪🔍✨

Alzheimer's Disease: Why Tau Holds the Key to New Therapies Recent breakthroughs have reignited the focus on Tau as a prime therapeutic target in Alzheimer's Disease (AD). While amyloid plaques have dominated research for decades, Tau pathology's extensive presence and correlation with cognitive decline demand closer attention. Here's why Tau is a compelling target for future AD therapeutics: Ubiquitous Pathology: Tau tangles, composed of hyperphosphorylated Tau protein, are present in a vast majority of AD cases, unlike the variable amyloid plaque burden. Early Intervention Potential: Tau pathology often precedes significant neuronal loss and clinical symptoms, offering a window for therapeutic intervention before irreversible damage occurs. Diverse Therapeutic Strategies: The multifaceted nature of Tau pathology presents a rich landscape for drug development. Approaches range from inhibiting Tau aggregation to promoting its clearance and microtubule stabilization. Stay tuned for future posts delving into the latest scientific advancements in Tau-targeted therapies! Let's foster a dynamic discussion about Tau's role in AD and its potential to unlock new avenues for treatment. #Alzheimers #Tau #NeurodegenerativeDisease #Neuroplasticity #Microtubules #ADResearch P.S. Are you investigating a therapy for AD? At IAG, IMAGE ANALYSIS GROUP we understand the complexity of Tauopathies, Dementias, and other forms of neurodegeneration. Reach out to me or imaging.experts@ia-grp.com to see how our neuroscience expertise can boost your clinical trial plans through medical imaging.

📃Scientific paper: T‐type calcium channels as therapeutic targets in essential tremor and Parkinson's disease Abstract: Neuronal action potential firing patterns are key components of healthy brain function. Importantly, restoring dysregulated neuronal firing patterns has the potential to be a promising strategy in the development of novel therapeutics for disorders of the central nervous system. Here, we review the pathophysiology of essential tremor and Parkinson's disease, the two most common movement disorders, with a focus on mechanisms underlying the genesis of abnormal firing patterns in the implicated neural circuits. Aberrant burst firing of neurons in the cerebello‐thalamo‐cortical and basal ganglia‐thalamo‐cortical circuits contribute to the clinical symptoms of essential tremor and Parkinson's disease, respectively, and T‐type calcium channels play a key role in regulating this activity in both the disorders. Accordingly, modulating T‐type calcium channel activity has received attention as a potentially promising therapeutic approach to normalize abnormal burst firing in these diseases. In this review, we explore the evidence supporting the theory that T‐type calcium channel blockers can ameliorate the pathophysiologic mechanisms underlying essential tremor and Parkinson's disease, furthering the case for clinical investigation of these compounds. We conclude with key considerations for future investigational efforts, providing a critical framework for the development of much needed agents capable of targeting the dysfunctional circuitry underlying movement disorders such a... Continued on ES/IODE ➡️ https://etcse.fr/8xoN ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: T‐type calcium channels as therapeutic targets in essential tremor and Parkinson's disease Abstract: Neuronal action potential firing patterns are key components of healthy brain function. Importantly, restoring dysregulated neuronal firing patterns has the potential to be a promising strategy in the development of novel therapeutics for disorders of the central nervous system. Here, we review the pathophysiology of essential tremor and Parkinson's disease, the two most common movement disorders, with a focus on mechanisms underlying the genesis of abnormal firing patterns in the implicated neural circuits. Aberrant burst firing of neurons in the cerebello‐thalamo‐cortical and basal ganglia‐thalamo‐cortical circuits contribute to the clinical symptoms of essential tremor and Parkinson's disease, respectively, and T‐type calcium channels play a key role in regulating this activity in both the disorders. Accordingly, modulating T‐type calcium channel activity has received attention as a potentially promising therapeutic approach to normalize abnormal burst firing in these diseases. In this review, we explore the evidence supporting the theory that T‐type calcium channel blockers can ameliorate the pathophysiologic mechanisms underlying essential tremor and Parkinson's disease, furthering the case for clinical investigation of these compounds. We conclude with key considerations for future investigational efforts, providing a critical framework for the development of much needed agents capable of targeting the dysfunctional circuitry underlying movement disorders such a... Continued on ES/IODE ➡️ https://etcse.fr/8xoN ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

Examining the Function of the #BloodBrainBarrier in #TuberousSclerosisComplex New research from the Developmental Synaptopathies Consortium (DSC): https://lnkd.in/gw4fim-U Tuberous sclerosis complex (TSC) is a genetic condition that affects many organs and can cause benign tumors in the skin, kidney, brain, heart, eyes, lungs, and other organs. The most severe symptoms—including seizures, intellectual disability, autism, and behavioral problems—result from complications in the central nervous system. Although these neurological complications are well-understood, less is known about how the genetic mutations that cause TSC might affect different components of the brain, including the blood-brain barrier. In this study, researchers examined the function of the blood-brain barrier in TSC. The team created TSC patient-specific brain tissue models to explore how mutations in the TSC2gene affect the blood-brain barrier. Results show altered function of a blood-brain barrier generated from TSC2 mutant cells, which can improve with treatment of the drug rapamycin or replacement of mutant cells with astrocytes (glial cells in the brain) that do not carry the mutation. Authors note that these findings demonstrate the importance of their methods in ongoing research for TSC and other neurogenetic disorders.