Ever wonder why some CAR-T cell therapies show better efficacy than others? This week's #RayBioRead is a groundbreaking study published in @Nature focused on the role of tonic signaling in CAR-T cell function. The research, led by Chen, J., Qiu, S., Li, W. et al, identifies positively charged patches (PCPs) on CARs as drivers behind spontaneous CAR activation. By manipulating these PCPs, researchers were able to fine-tune CAR-T cell behavior, enhancing effectiveness and reducing exhaustion. This discovery opens doors for next-gen CAR-T designs. Learn more: https://lnkd.in/gxRguPwx Featured RayBiotech Product: https://lnkd.in/e7NdF3-H
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The first commercially available dual reporter assay from ThermoFisher Scientific is now here, revolutionizing how you can unveil the complex interactions in studying cell signaling pathways. Learn more about Invitrogen ProcartaPlex Signaling Dual Reporter assays, as well as other novel product offerings from our partners, in the latest xMAP Resource Round-Up newsletter, now available in your inbox. Not yet a subscriber? Sign up now for the latest multiplexing updates, news, and product information in our free multiplexing newsletter: https://hubs.li/Q02rkdj80 #newsletter #xMAP #sciencenews #healthscience
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Our team developed the novel Dual Reporter Format as part of our Signaling assays, which allows for measuring 2 attributes of a protein simultaneously on the same bead (e.g. total and phosphorylated proteins) https://lnkd.in/gVi8HmWq
The first commercially available dual reporter assay from ThermoFisher Scientific is now here, revolutionizing how you can unveil the complex interactions in studying cell signaling pathways. Learn more about Invitrogen ProcartaPlex Signaling Dual Reporter assays, as well as other novel product offerings from our partners, in the latest xMAP Resource Round-Up newsletter, now available in your inbox. Not yet a subscriber? Sign up now for the latest multiplexing updates, news, and product information in our free multiplexing newsletter: https://hubs.li/Q02rkdj80 #newsletter #xMAP #sciencenews #healthscience
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Are you ready to revolutionize your approach to Cell Therapy Development? Dive into our exclusive application note series and uncover how Beacon optofluidic technology is transforming the landscape during the discovery, validation, and clinical translation phases. Why Explore Our Case Studies? 🔹 Rapid Screening: Quickly and effectively screen CARs/TCRs, driving personalized medicine forward. 🔹 Deep Cellular Insights: Gain unmatched understanding of cellular functions and behaviors to identify potential relapse mechanism. 🔹 Enhanced Cell Assessment: Profile top TCR candidates and TIL cytotoxicity in depth. https://hubs.ly/Q02Gm62q0
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Ready to dive into the future of single cell functional analysis? Join me at the Bruker Cellular Analysis Virtual Summit where we're unveiling groundbreaking advancements! Discover the new capabilities of the Beacon Platform and how it's revolutionizing antibody discovery for even the toughest targets. Learn how researchers are achieving remarkable >99% monoclonality with cell line development and making progress towards personalized T cell immunotherapies. https://lnkd.in/graPwD-x
Understand the Life of Single cell
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Osteoinductive & osteoconductive biomaterials are revolutionizing the treatment of bone defects, offering hope for improved patient outcomes. However, understanding their interaction with the immune system is key to their success. Our blog explores this essential aspect, offering valuable insights into ⤵ 🔵 In vitro evaluation methods 🔵 Importance of cell culture models mirroring primary osteoblast cells 🔵 Role of osteoclasts in biomaterial development 🔵 Assessing biomaterial functionality 🔵 Advancements in 3D models for testing Read more: https://bit.ly/43SamYs
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#GTIHighlights from 2023 - In a preclinical study led by Dr. Krystof Bankiewicz, the delivery of AAV-based #genetherapy encoding GDNF in the brain prevented the return to alcohol use behaviors in a non-human primate model: https://go.osu.edu/CcV3
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Age: 27, ESG @ Morningstar | 1 Patent, 3 pending | Climate Finance- CFA| AIML- Caltech | Healthcare @ DY Patil | Energy @ SIIB| DS& A @ Upgrad| IAF Winner | MIT India Initiative| Pro Bono Placement Facilitator
Unveiling the New Vanguard of Radiation #Therapy – Challenge Issued! In a world where precision is the fine line between therapy and trauma, we've tipped the scales of innovation. Harnessing the prowess of Monte Carlo simulations and armed with a fresh arsenal of material combinations, we've slashed #toxicity levels down to a near-mythical 4% in radiation or #ionizationtherapy. This isn't just a step forward; it's a leap towards a future where healing is no longer a gamble with fate. This breakthrough is no accident. It's the fruit of rigorous academia fused with relentless curiosity – a testament to the PGP in #AI and #ML from Caltech that I had the fortune to dive into just a month ago. And now, as I stand at this crossroads of discovery and application, I throw down the gauntlet. To the #clinical research maestros across the globe, I present a challenge – a spark of competition to push the boundaries of what we believe is possible. A slice of my code is my torchbearer, a beacon to lure the brilliant minds, the silent innovators, and the dauntless institutions to take this further than I could alone. Let's reshape the narrative of #cancer treatment together. Are you ready to join the ranks of the audacious? The game is on. AstraZeneca Fortrea EVERSANA Merck Healthcare Roche Celgene Pfizer Johnson & Johnson Society for Technology Management (STEM) Novo Nordisk Indian Institute of Science (IISc) #RadiationTherapyRevolution #MonteCarloMethod #HealthTechInnovation #CaltechAI #ChallengeAccepted #JoinTheVanguard
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The 𝗖𝗼𝗺𝗽𝗹𝗲𝘅 𝗕𝗶𝗼𝗲𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴 𝗳𝗼𝗿 𝗖𝗲𝗹𝗹 𝗧𝗵𝗲𝗿𝗮𝗽𝗶𝗲𝘀 𝗦𝘂𝗺𝗺𝗶𝘁 is the 𝗽𝗿𝗲𝗺𝗶𝗲𝗿 𝗲𝘃𝗲𝗻𝘁 𝗳𝗼𝗿 𝗯𝗶𝗼𝗲𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴 𝗲𝘅𝗽𝗲𝗿𝘁𝘀 to network and gain insights into TME biology, precise payload delivery, and early risks in developing advanced logic-gated and dual-targeted cell therapies for more effective treatments. 🚨𝗝𝘂𝘀𝘁 𝗥𝗲𝗹𝗲𝗮𝘀𝗲𝗱: 𝗧𝗵𝗲 𝗳𝘂𝗹𝗹 𝗮𝗴𝗲𝗻𝗱𝗮 𝗶𝘀 𝗻𝗼𝘄 𝗮𝘃𝗮𝗶𝗹𝗮𝗯𝗹𝗲! - https://ter.li/o1ecxu With increasing FDA scrutiny on CAR-T therapies and challenges with solid tumors, 𝘁𝗵𝗶𝘀 𝗲𝘃𝗲𝗻𝘁 𝗶𝘀𝗻'𝘁 𝗷𝘂𝘀𝘁 𝗶𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝘁 - 𝗶𝘁'𝘀 𝗲𝘀𝘀𝗲𝗻𝘁𝗶𝗮𝗹. 𝗗𝗼𝗻'𝘁 𝗺𝗶𝘀𝘀 𝘆𝗼𝘂𝗿 𝗰𝗵𝗮𝗻𝗰𝗲 𝘁𝗼: 💡Overcome the tumor microenvironment 💡Enhance cell persistence 💡Ensure patient safety with cutting-edge technology 𝗙𝗶𝗻𝗱 𝗢𝘂𝘁 𝗠𝗼𝗿𝗲 𝗛𝗲𝗿𝗲 - https://ter.li/o1ecxu #ComplexBioengineeringforCellTherapiesSummit
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🔧 𝗖𝗲𝗹𝗹 𝗧𝗵𝗲𝗿𝗮𝗽𝘆 𝗕𝗶𝗼𝗲𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴 𝗘𝘅𝗽𝗲𝗿𝘁𝘀 - 𝗗𝗼𝗻'𝘁 𝗠𝗶𝘀𝘀 𝗧𝗵𝗶𝘀! The 𝗖𝗼𝗺𝗽𝗹𝗲𝘅 𝗕𝗶𝗼𝗲𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴 𝗳𝗼𝗿 𝗖𝗲𝗹𝗹 𝗧𝗵𝗲𝗿𝗮𝗽𝗶𝗲𝘀 𝗦𝘂𝗺𝗺𝗶𝘁 is the 𝗽𝗿𝗲𝗺𝗶𝗲𝗿 𝗲𝘃𝗲𝗻𝘁 𝗳𝗼𝗿 𝗯𝗶𝗼𝗲𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴 𝗲𝘅𝗽𝗲𝗿𝘁𝘀 to network and gain insights into TME biology, enhance payload delivery, and mitigate risks in developing advanced logic-gated and dual-targeted cell therapies for more effective treatments. 🚨 𝗝𝘂𝘀𝘁 𝗥𝗲𝗹𝗲𝗮𝘀𝗲𝗱: 𝗧𝗵𝗲 𝗳𝘂𝗹𝗹 𝗮𝗴𝗲𝗻𝗱𝗮 𝗶𝘀 𝗻𝗼𝘄 𝗮𝘃𝗮𝗶𝗹𝗮𝗯𝗹𝗲! - https://ter.li/o1ecxu If you're an R&D focused bioengineer looking to improve your current cell therapy offerings, make sure you register for the premiere knowledge sharing platform and technical showcase for cell therapy experts. 𝗦𝗲𝗲 𝘁𝗵𝗲 𝗙𝘂𝗹𝗹 𝗔𝗴𝗲𝗻𝗱𝗮 & 𝗦𝗽𝗲𝗮𝗸𝗲𝗿 𝗙𝗮𝗰𝘂𝗹𝘁𝘆 𝗵𝗲𝗿𝗲: https://ter.li/o1ecxu #ComplexBioengineeringforCellTherapiesSummit #CellTherapy
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Learn how Vanderbilt University Medical Center saved space, improved efficiency, and minimized the risk associated with their cell therapy manufacturing utilizing a step-wise approach to implementing #automation. https://cytiva.link/0y7gi #digitaltransformation
Vanderbilt moves towards a paperless cell therapy process: Four small steps for VUMC, one big step towards a digital transformation - Cytiva
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