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Ever wonder why some CAR-T cell therapies show better efficacy than others? This week's #RayBioRead is a groundbreaking study published in @Nature focused on the role of tonic signaling in CAR-T cell function. The research, led by Chen, J., Qiu, S., Li, W. et al, identifies positively charged patches (PCPs) on CARs as drivers behind spontaneous CAR activation. By manipulating these PCPs, researchers were able to fine-tune CAR-T cell behavior, enhancing effectiveness and reducing exhaustion. This discovery opens doors for next-gen CAR-T designs. Learn more: https://lnkd.in/gxRguPwx Featured RayBiotech Product: https://lnkd.in/e7NdF3-H

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