ReCode Therapeutics’ Post

mRNAs can be instructed to produce any protein in the body, using the cells own natural machinery to potentially treat diseases and prevent infections. This opens up a whole new way to flexibly and successfully treat and manage diseases, ranging from vaccine development to therapeutics. Listen to Dr. Aditi Mehta describe the science behind mRNA synthesis and RNA delivery vehicles. Merck Life Science #mRNA #Innovation

mRNAs can be instructed to produce any protein in the body, using the cells own natural machinery to potentially treat diseases and prevent infections. This opens up a whole new way to flexibly and successfully treat and manage diseases, ranging from vaccine development to therapeutics. Listen to Dr. Aditi Mehta describe the science behind mRNA synthesis and RNA delivery vehicles. MilliporeSigma #mRNA #Innovation

Do you have research on exploring the therapeutic effects of transient CAR/TCR expression using mRNA delivery? Abstract topic #4 “CAR/TCR mRNA Therapies” is the right choice for YOU! Do not miss the chance to take the stage at #ICLE2025: https://bit.ly/3WCHJgf #lymphocytes #lymphocytesengineering #CARTcells

Read our newest work on ER-to-Golgi transport of mucin-2, now deposited at the bioRxiv preprint server. in this paper, we show how COPII-coated vesicle-mediated transport of very large mucin-2 is facilitated by enlargement of the vesicles making use of anxiliary proteins TANGO1, cTAGE5 and KLHL12. We also show how inhibition of ER-to-Golgi trafficking of mucin-2 is associated with ER stress reminiscent of ER stress observed in Inflammatory Bowel Disease using cell assays and clinical patient mRNA data. Access the paper here: https://lnkd.in/eZ7_JxuP

A few months ago, Christine Boswell and Elaine Peters "challenged" (a.k.a. permitted) me to share a few thoughts--and metaphors--on the mRNA world at the BioPhorum ATMP conference. But as much fun as it would be to read an exhaustive outline of my presentation, I chose instead to share the one takeaway that I'd argue rises above the others--especially as I see more crossover happening between the cell-based CGT and mRNA fields. In the following article, I share a few learnings from outside the mRNA universe that showcase just how much potential we have to learn from the #advancedtherapies that have come before our mRNA therapies.

TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue https://lnkd.in/guNHktE8

John Matthews, our Chief Medical Officer, speaks on the state of our cystic fibrosis research pipeline: "Our inhaled CFTR mRNA therapy is optimized to reach the correct cells in the lungs and instruct them to make a functional version of the CFTR protein. This would represent an exciting step in developing a successful therapy for all CF patients.” This development addresses a critical gap in #CF treatment, particularly for Class I #CFTR mutations where no protein is produced. #CysticFibrosis #InnovationInHealthcare #ReCodeTherapeutics

Have you read Anna Rose Welch's most recent article, "A "Hot Take" On mRNA Scale-Up ? Anna is writing a multi-part “mini-series” of RNA industry “Hot Takes,” She shares several aspects that jumped out at her from the BioPhorum ATMP Event in March. Here's "Hot Take #1" - There Are More Pitfalls In Scaling #mRNA/ #RNA Than We Admit. Read more here: https://lnkd.in/gzpUamAZ #mrna #rna #scaleup #ATMP

📣 New article published by the team of Silvia Gregori! The review authored by Konstantina Morali, Gloria Giacomello, Michela Vuono and Silvia Gregori provides an overview of current knowledge on the role of tolerogenic dendritic cells (tolDC) in health and disease. The review is focused on (i) IL-10 production, (ii) functional characterization of in vitro generated tolDC, (iii) molecular and metabolic changes occurring in tolDC induced by tolerogenic agents, (iv) clinical applications of tolDC-based therapy, and on (v) new perspectives in the generation of effective tolDC. Congratulations to all co-authors! Link to the paper: https://lnkd.in/dfE-nWcz #HaDEA, #EU, #immunotherapy, #tolerogenicdendriticcells

Unlocking the mysteries of single-cell data! #Decipher a novel computational pipeline to extract context-specific mechanistic insights from single-cell profiles. 🎯 It builds integrated cell signaling networks in a data-driven manner, uncovering key drivers of disease and cellular responses to therapies like mRNA vaccines. This could lead to faster drug discovery & personalized medicine! Quick Read: https://lnkd.in/gVXMdj4m #bioinformatics #singlecell #rnaseq #machinelearning #sciencenews