Dianox

Groundbreaking therapy uses magnetic fields to manipulate neurons. Researchers have developed a gene therapy using magnetic fields to control brain circuits, potentially treating Parkinson's disease, depression, obesity, and chronic pain. Unlike optogenetics, this magnetogenetics technique enables real-time control of neurons without invasive implants. By engineering ion channels that respond to ferritin, strong magnetic fields can activate or deactivate neurons. In mouse studies, this method effectively reduced Parkinson's symptoms. It can also use smaller magnets like those in TMS devices, showing promise for various neurological and psychiatric conditions without safety concerns. Read more: https://lnkd.in/dYqBiw3a #medical #research #genetherapy #science #brainhealth

Innovative approach turns injectable chemotherapy into convenient pills. Stanford scientists have created a molecular tag that can transform IV chemotherapy drugs into effective oral pills. This tag enhances drug absorption by being water-soluble in the stomach and oil-soluble once in cells. In mouse tests, it made vemurafenib 100% bioavailable and allowed paclitaxel to be effective as a pill, even outperforming its IV version without added toxicity. This innovation could make chemotherapy more convenient, though human trials are still necessary. Read more: https://lnkd.in/dzX-trEH #medical #research #cancerresearch #science #medicine

Smart nanomedicine could end severe hypoglycemia in diabetics. Researchers at UCLA have created a nanomedicine that releases glucagon to prevent severe hypoglycemia in diabetics. The glucagon is encapsulated in micelles, which only disassemble when blood glucose levels drop dangerously low. In mouse tests, this solution restored normal blood sugar within 40 minutes during hypoglycemia while staying inactive at safe levels. This innovation could help diabetics avoid dangerous low blood sugar episodes, though further research is needed before clinical use. Read more: https://lnkd.in/dTkmpt7K #medical #research #diabetes #science #medicine

Tiny skin-stabbing stars revolutionize topical treatments. Researchers at Switzerland's Empa institute have created tiny nanoceramic "stars" made of aluminum oxide to enhance topical medication effectiveness. These 0.8 mm star-shaped structures are mixed into a gel and, when applied to the skin, create microscopic holes in the epidermis. This allows medication to penetrate painlessly, potentially replacing microneedle patches and hypodermic needles for larger or irregular skin areas. Read more: https://lnkd.in/ggsEq2hy #medical #research #medtech #science #health

New laser-based headset can measure blood flow, assess risk of stroke. Researchers from Caltech and USC have created a non-invasive, wearable laser device that assesses stroke risk by monitoring brain blood flow. Using speckle contrast optical spectroscopy (SCOS), the headband projects infrared laser light through the skull to evaluate blood flow changes under stress. This method measures blood vessel stiffness, which correlates with stroke risk. The device offers real-time feedback, presenting a portable and affordable alternative to traditional assessments. Future plans include using machine learning for enhanced analysis and real-time stroke detection. Read more: https://lnkd.in/dJdcvGmj #medical #research #medtech #science #brainhealth

Stem cell transplant cures Type 1 Diabetes patient after 11 years. A stem cell therapy has effectively cured a 25-year-old woman with type 1 diabetes, allowing her to live without insulin for over a year. The process involved isolating stem cells from her fat tissue, converting them into pancreatic islet cells, and transplanting them into her abdomen. She gradually reduced her insulin dependence and maintained healthy blood sugar levels. While immune suppression is needed to prevent autoimmune attacks, the trial shows promise and continues with two more participants. Read more: https://lnkd.in/dtWB4dbH #medical #research #diabetes #science #drugdevelopment

Spinogenix is starting human trials for SPG302, a once-a-day pill designed to regenerate lost nerve cell connections as a treatment for schizophrenia. This new approach aims to address synapse loss and improve treatment outcomes for patients resistant to existing therapies. The Phase 2 clinical trial is actively enrolling participants to evaluate the pill's safety and effectiveness. Read more: https://lnkd.in/dSsXhKFH #medical #research #schizophrenia #science #treatment

Discovery of new type of cell with potential to boost tissue repair. Researchers have discovered a new type of bipotent progenitor cell called 'EndoMac,' which matures into both endothelial cells and macrophages, significantly enhancing wound healing. These cells, found in the outer layer of the aorta in adult mice, help grow blood vessels during the healing process. In experiments with diabetic mouse models, transplanting these progenitor cells led to dramatic improvements in wound healing within days. The study aims to identify a human equivalent and explore the cells' potential for healing skin and muscle, marking a significant advancement in blood vessel regeneration and chronic wound treatment. Read more: https://lnkd.in/dspxgmKg #medical #research #woundhealing #chronicwound #medtech

A recent study led by Oregon Health and Science University found that placing defibrillator pads in an anterior-posterior (AP) configuration—one on the chest and one on the back—can increase survival rates after an out-of-hospital cardiac arrest (OHCA) by 264%. Traditionally, pads are placed in an anterior-lateral (AL) position, which has been linked to lower survival rates. Analyzing data from 255 patients with shockable heart rhythms, the researchers discovered that those with the AP placement had significantly higher rates of return of spontaneous circulation (ROSC). This new positioning may allow for a more effective delivery of electrical current to the heart, although practical challenges exist in emergency situations. The findings could spur further research into improving resuscitation methods. Read more: https://lnkd.in/duT_kd6a #medical #research #hearthealth #cardiacarrest #medtech

Giving T cells extra batteries supercharges them against cancer. Scientists have developed a novel method to supercharge T cells, our immune system's primary cancer fighters, by giving them "extra batteries" in the form of mitochondria, the cell's energy producers. Cancer often exhausts T cells by draining their energy, but researchers at Brigham and Women's Hospital found that donating mitochondria from bone marrow stromal cells to T cells significantly enhanced their ability to attack tumors. In mouse studies, these "Mito+" T cells shrank tumors and dramatically improved survival rates. This breakthrough could pave the way for more effective immunotherapies using organelle transplants. Read more: https://lnkd.in/dhgjfqnk #medical #research #cancer #oncology #tcell