Revvity for Diagnostics’ Post

【Inhibitory Effect of Medicinal Secondary Compounds on Carcinogenic Cell-Lines】 Full article: https://lnkd.in/gMUsF4jy (Authored by Yousef M. Almutairi, et al., from Tennessee State University (USA), etc.) In recent times, there has been a surge in the investigation of the therapeutic characteristics of plants due to their broad medical and economic characteristics, as well as the successful utilization of specific plants in the treatment of human illnesses. #Senna (Cassia) plant is an important plant that is used to extract #natural_compounds and products that are applied in the treatment of tumors. This paper describes the investigation of the cytotoxic effects of the plant Senna's secondary compounds when exposed to different types of #cancer cells. #Anticancer

(2/n) Extracellular vesicles (EVs) do many different things in biology, and we can also do a lot of very cool stuff with EVs. I have been thinking about how to survey this vast EV “forest” vs microscopic “tree”, and here is how I'm organizing key categories of EV applications where #Simoa could be very useful (*disclaimer: this is not meant to be exhaustive, and I’m also constantly updating my EV perspectives.) 1. Characterizing/enumerating EV population(s) or profiling specific EV populations (e.g., disease-specific or tissue-specific). 2. EV surface biomarker profiling/quantification (overlap with No. 1) 3. Evaluating EV isolation methods (assessing EV yield & purity, etc.) 4. EV cargo content biomarker analysis 5. Special EV biomarker applications, such as: (a) Tx targeting specific receptors (e.g., ADCs) or antigens (b) Heme applications (huge potentials here) (c) Blood-based EV biomarkers as surrogates for tumor immune microenvironment (and potential for tissue-blood paired testing) 6. EV Therapeutics – critical needs for robust mfg QC and bioassays I hope I’m whetting your EV appetite here, and I’ll expand on the above individually next week. Have a great Friday/weekend/Easter! #ExtracellularVesicles #Liquidbiopsy #BiomarkerTesting

🔬 Breakthrough Therapies or Regulatory Minefield? The Truth About ATMPs Revealed! Advanced Therapy Medicinal Products (ATMPs) are revolutionizing medicine, but navigating their development is like walking through a regulatory labyrinth. 🧬🧪 Our article uncovers: ✅Why ATMPs are the next frontier in treating cancer and rare disorders ✅How global health authorities are fast-tracking these innovations ✅The complex classification system of cell and gene products Don't miss out on understanding the future of medicine. Read our in-depth analysis now and stay ahead of the curve: https://shorturl.at/0BOc6 #ATMP #CGT #BiotechInnovation #RegulatoryAffairs

Organoid vs. Spheroid in 3D Cell Cultures Organoids, the intricate replicas of specific organs, excel in mimicking both the structure and function of human tissues. They offer invaluable insights into disease mechanisms and potential treatments. On the other hand, spheroids, though simpler, provide a versatile platform for studying various cellular behaviours, including drug responses and cancer microenvironments. Share your insights in the comments and be part of the discussion. #CellCulture #OrganoidVsSpheroid #MedicalResearch #StemCells #HealthcareInnovation #ResearchInsights #Biotechnology #LabLife #ScienceDiscussion #AskTheExpert #ResearchDebate

At last, UK citizens can really embrace personalised medicine, starting with Clopidogrel as the first mainstream drug to be the subject of NICE guidance. Preemptively testing patients presenting with a TIA or stroke is now essentially mandated before prescribing Clopidogrel, an antiplatelet medication, as it does not work in 32% of UK citizens, who are then put at an increased risk of having another stroke by up to 46% compared to those whose genes allow the drug to work as intended! Unless you happen to be Pakistani or Bangladeshi, in whom the drug does not work in up to 57%!! PGx allows more equitable treatment across ethnicities by looking at those genes related to drug metabolism. Genes are what they and knowing which ones you have is crucial before prescribing many of the drugs we use in the UK. The Mantara PGx saliva test provides information telling you which of 77 commonly prescribed medications will suit you, which ones might need a different dose and which ones to avoid. All evidence-based and following the Prepare study, published in the Lancet last February. MHRA-registered and UKCA and CE marked: a test you can trust. #mantara #nhs #personalisedmedicine #PGx #pharmacogenomics

🌟 Tackling Organ Fibrosis: A New Frontier 🌟 Fibrosis is a major health issue, affecting millions and contributing to nearly half of all worldwide mortality. It's a relentless condition, where tissue damage escalates into debilitating organ failure. Despite the gravity, we’ve only scratched the surface in antifibrotic drug development. Enter BRD4 – one of the shining stars in the BET protein family. It's a key player in gene expression tied to inflammation and fibrosis. Recent research highlights the potential of BRD4 inhibition as a promising antifibrotic strategy. However, no BRD4 inhibitors are yet approved for clinical use. This review explores the intricate role of BRD4 and its inhibitors in combating organ fibrosis. Could we be on the brink of a breakthrough in therapeutic strategies for fibrotic diseases? The potential is enormous, but challenges remain. Exciting times ahead in the fight against fibrosis! Are we ready to turn the tide? 🌿💡 Read Research 👉🏻 https://lnkd.in/dCFuJibv #research #pubmed

📢We share the #Review "DNA Methylation and Histone Modification in Low-Grade Gliomas: Current Understanding and Potential Clinical Targets" 👥by Ahmad Ozair, Vivek Bhat, et al. The Johns Hopkins University, St. John's National Academy of Health Sciences Link here👉 https://lnkd.in/dmwQQ4x2 Keywords: methylation; methylomics; G-CIMP; MGMT; DNMT; ATRX; H3K27M; CpG island; tumor suppressor; methyltransferases; histone acetylation

#HighlyCitedPapers 📝 Diagnostic and Prognostic Biomarkers in Renal Clear Cell Carcinoma — Weaver, et al. In this paper, the authors focused on the #molecular changes associated with renal clear cell #carcinoma development, along with #gene expression and protein signatures, to emphasize the utilization of these molecular profiles in clinical practice. Full text is available 👇 https://lnkd.in/dw7a9V6a #medicine #health #research #science

Treating diseases with a one-drug-fits-all approach has shown not effective in many cases. The approach of precision medicine by the use biomarkers, functional drug testing, and genomic and tissue profiling seems to be a promising way to enhance treatment efficacy.  https://lnkd.in/eg-n8ajD  #precisionmedicine #tissueprofiling #biomarkers

Mechanistic insights and potential senescence biomarkers. A new approach to monitor the senescence burden in the aging population and offer promising therapeutic targets for interventions.