ROSARIO FERNANDEZ GODINO’s Post

Clinicians with an interest in thrombophilia: Attend our next NBCA Journal Club session! The NBCA Journal Club highlights groundbreaking research in thrombosis and thrombophilia and features a manuscript author as part of the discussion. Our next session convenes June 18, 2024 from 2-3 p.m. ET to discuss, "Antithrombin Therapy: Current State and Future Outlook," published in Clinical and Applied Thrombosis/Hemostasis in 2023. The paper’s author, George M. Rodgers, III, MD, PhD, Professor of Medicine in the Division of Hematology and Hematologic Malignancies at the University of Utah School of Medicine, will join us to discuss his research. The session’s learning objectives: - Understand the genetic and acquired factors contributing to antithrombin (AT) deficiency and its implications. - Explore current treatment strategies for managing AT deficiency. - Identify specific patient populations and use cases where AT therapy may be considered and evaluate its potential benefits. - Investigate advancements and future directions in research, diagnosis, and treatment approaches for AT deficiency to enhance clinical outcomes and patient care. Register: bit.ly/NBCAJournalClub2024 #stoptheclot #nbcajounalclub #bloodclots #thrombophilia #thrombosis #antithrombintherapy #antithrombindeficiency #bloodcloteducation #continuingeducation

📍 Neuronally differentiated endothelial cell subtype regulates organ blood flow and immune balance Gyarmati et al. identified and characterized neuro-endothelial cells (NEC), a novel, minority subtype of scattered endothelial cells with a well-defined arteriovenous zonal localization exclusively in small resistance (strain) arterioles, and with the highest density in the brain>retina>kidney. Key points ✔️ Neuronal nitric oxide synthase (Nos1) and cytokine-like 1 (Cytl1) as top NEC biomarkers ✔️NEC and Nos1-dependent vasodilation/vasoconstriction of intact brain and kidney arterioles and elevation/reduction in blood flow ✔️ Segmental arteriolar vasoconstrictions, reduction in vascular density and organ blood flow, increased vascular permeability and immune cell homing caused by silencing NEC Nos1 and Cytl1 ✔️ Vasodilation and increased blood flow acutely, and increased capillary density and clonal EC remodeling chronically triggered by Cytl1 administration. ➡️ More details: https://lnkd.in/e3KEj-WE #UniversityofSouthernCalifornia #spatialomics #spatialbiology #singlecellanalysis #singlecell

Recent findings re: commercial immunoassays for identifying pathophysiology can benefit the #ClinicalDevelopment of new #AlzheimersDisease treatments. Read the blog. https://www.calyx.ai/s/7r7 #ClinicalTrials #MedicalImaging #ChooseCalyx

So proud of extraordinary lab members and colleagues Isabel Lam and Alain Ndayisaba with many collaborators and supporters for bringing this opus to fruition! Protein aggregation pathologies in #Parkinson #PD #DLB #MSA and other forms of #neurodegeneration and #dementia are diverse and complex. This is critical because these pathologies are i) often considered one and the same, ii) not distinguishable using conventional pathological markers -- and -- iii) many biological and drug discovery screens thus do not distinguish among them. Phenotypic screens are only as good as the phenotype one is screening against! In this work we present a robust, tractable and screenable suite of human and patient-specific #stemcell #IPS #IPSC models now puts this complexity within reach in the laboratory dish. Check out the link and more in Isabel Lam's post! The cell lines and piggybac constructs have been licensed/shared with numerous academic and industry entities to date. Reach out to us if you'd like to use these models.

Clinicians with an interest in thrombophilia: Attend our next NBCA Journal Club session! The NBCA Journal Club highlights groundbreaking research in thrombosis and thrombophilia and features a manuscript author as part of the discussion. Our next session convenes June 18, 2024 from 2-3 p.m. ET to discuss, Antithrombin Therapy: Current State and Future Outlook, published in Clinical and Applied Thrombosis/Hemostasis in 2023. The paper’s author, George M. Rodgers, III, MD, PhD, Professor of Medicine in the Division of Hematology and Hematologic Malignancies at the University of Utah School of Medicine, will join us to discuss his research. The session’s learning objectives: - Understand the genetic and acquired factors contributing to antithrombin (AT) deficiency and its implications. - Explore current treatment strategies for managing AT deficiency. - Identify specific patient populations and use cases where AT therapy may be considered and evaluate its potential benefits. - Investigate advancements and future directions in research, diagnosis, and treatment approaches for AT deficiency to enhance clinical outcomes and patient care. Register: bit.ly/NBCAJournalClub2024 #stoptheclot #nbcajounalclub #bloodclots #thrombophilia #thrombosis #antithrombintherapy #antithrombindeficiency #bloodcloteducation #continuingeducation

The Center for Transcriptional Medicine (CTM) at the University of Pittsburgh [https://ctm.pitt.edu/] is pioneering a new approach to treating end-stage organ disease. Instead of relying on donor organs for transplants, CTM focuses on healing the organs themselves. The center’s research aims to leverage an integrated multi-omics approach to identify master regulators of cellular identity in diseased tissues, known as transcription factors, that are disrupted during disease progression. https://lnkd.in/e_Tbm--k #precisionmedicine

Endo-lysosomes express several functionally diverse ion channels, crucial for regulating organelle trafficking and intracellular signalling as well as maintaining the acidic luminal pH for optimal enzymatic activity. Dysfunctions within the endo-lysosomal system are associated with multiple disorders including lysosomal storage disorders and neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Lysosomal ion channels have, therefore, gained significant attention as potential targets for novel therapeutics.   Due to their localisation to small intracellular compartments, endo-lysosomal ion-channels have been historically challenging to study using conventional patch-clamp techniques. However, recent advances in lysosomal biology make it possible to enlarge and extract endo-lysosomes for subsequent recording using manual patch-clamp electrophysiology. This approach allows for the characterisation of channel function within the native environment, facilitating better physiological understanding.   In this video we demonstrate our endo-lysosomal extraction technique to enable the study of ion channels found on the lysosomal membrane. Find out more at: https://lnkd.in/ejXtUHJG #ionchannels #drugdiscovery #cro #patchclamp #lifesciences #alzheimersdisease #parkinsonsdisease

Stephen T. Oh, MD, PhD, Co-Chief and Associate Professor of Medicine, Division of Hematology, Department of Medicine, Washington University School of Medicine in St. Louis, and has been published in Blood. The WashU group of researchers previously identified hyperactivation of NFκB pathway signaling in myeloproliferative neoplasms (MPNs). In this study we utilized genetic and pharmacologic approaches to comprehensively dissect the role of NFκB signaling components in MPN disease development. Learn more > https://lnkd.in/g4-mqnHE

✨ We would like to invite you to read this excellent paper by Paolo Severino et al. Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA): Focus on Coronary Microvascular Dysfunction and Genetic Susceptibility 🏥 Sapienza Università di Roma 👉 More info: https://lnkd.in/dVayi4aS 📑 This article belongs to the Special Issue Myocardial Infarction with Nonobstructive Coronary Arteries (MINOCA): Current Status, Challenges and Future Directions. #clinical #medicine #openaccess #myocardialinfraction #minoca #cardiology

【Medicine/Health】 Elucidating the Process of Bile Duct Formation in the Liver The bile ducts carry bile produced by hepatocytes from the liver to the small intestine. Bile duct epithelial cells lining the inner wall of bile ducts differentiate from progenitor cells common to hepatocytes; however, unlike hepatocytes distributed throughout the liver, they differentiate along the portal vein. Researchers from the University of Tsukuba have elucidated the mechanism underlying this process. This achievement could contribute to the development of artificial organs. Read more details here; https://lnkd.in/ggkMQqgx Original Paper; https://lnkd.in/gGWXnz2k