Roel Bienenmann’s Post

1,2-Dipalmitoyl-sn-glycero-3-phosphocholine(DPPC)is a phospholipid molecule commonly used in the study of biological membranes. It is composed of two palmitoyl fatty acid chains attached to the sn-1 and sn-2 positions of a glycerol backbone.DPPC is often employed as a model phospholipid in various research studies owing to its well-defined physical properties.It forms a gel phase at lower temperatures, and upon heating,undergoes a phase transition into a liquid-crystalline state. #phosphocholine #DPPC #phase #transition #crystalline #physical #properties https://lnkd.in/gAU74BFw

Pd-catalyzed C–N cross-coupling reactions of heteroaryl halides and amines remain challenging due to their ability to displace the supporting ligand via coordination to the metal center. To address this limitation, this paper reports development of a highly robust Pd catalyst supported by a new dialkylbiarylphosphine ligand, FPhos.

Serial Dilutions: ·        The purpose of a serial dilution is to estimate the concentration of a sample, or to obtain the desired concentration of a reagent, chemical or compound. ·        Serial dilution is a fundamental technique used in various scientific disciplines, particularly in microbiology, biochemistry, and analytical chemistry. Its significance lies in several key aspects. ·        In microbiology, serial dilution is crucial for counting the number of viable microorganisms in a sample. ·        In analytical chemistry, serial dilution is used for calibration purposes. By preparing a series of standard solutions with known concentrations, analysts can construct calibration curves to relate the measured signal (e.g., absorbance, fluorescence intensity) to analyte concentration. ·        Watch the video on how serial dilutions are made: https://lnkd.in/dMZMGWeW

PEG-MGF stands for Pegylated Mechano Growth Factor. It is a biologically engineered variant of the IGF-1 (Insulin-like Growth Factor-1) splice variant. These variants of IGF-1 are created during the body’s response to mechanical stimulation, such as exercise or injury. However, the biological activity of natural MGF is relatively short-lived. This fact has led scientists to develop a synthetic version, PEG-MGF. The MGF molecule is modified by adding Polyethylene Glycol (PEG). Hence the term “pegylation.”

In this review, summarized the types of PROTAC linkers, the design and optimization strategies used, and the impact of linker characteristics on PROTAC efficacy. The rational design of PROTACs must carefully consider linker characteristics to optimize biodegradation efficiency. Balancing factors such as length, flexibility, stability, hydrophilicity/hydrophobicity, steric properties, and functional groups is essential for developing effective and efficient PROTACs for targeted protein degradation. Last year, there has been a growing number of publications reporting progress in the design and optimization of PROTAC linkers. Enjoy your weekend reading! #PROTAC #linker #DrugDiscovery #Medchemistry https://lnkd.in/ekRD4zH4

Tandem Iqbal three component (3CR) and Ugi four component (4CR) coupling route to complex tripeptidyl ketones

Tackling Moisture Sensitivity in Oligonucleotide Synthesis: Novel Application of GC-VUV Detection Maximize yield and purity in Oligonucleotide synthesis using a novel approach to monitoring moisture that couples Gas Chromatography with VUV detection. Register now: https://lnkd.in/eGgg_92Y

The analysis of Tinospora cordifolia stem via High-Performance Thin-Layer Chromatography (HPTLC) across a spectrum of wavelengths (200-450 nm) using different solvent systems revealed varying numbers of phytoconstituents. At 200 nm, 25 constituents were detected, increasing to 31 at 400-450 nm. Notably, the solvent system Toluene: Acetone: Formic acid exhibited the highest diversity. This emphasizes the significance of wavelength variations in HPTLC fingerprinting, highlighting the optimal spectrum for lambda max (400-450 nm) to understand T. cordifolia's chemical profile for pharmacological insight. #HPTLC #secondarymetabolities

A new orthogonal deoxyfluoroalkylation/aromatization strategy that enables systematic preparation of countless numbers of highly substituted cyclohexan(en)one-containing substrates prior to conversion to the Ar–CF3 products. The methodology exploits readily accessible and programmable cyclohexa(en)none precursors as the starting precursors which undergo a reliable 1,2-addition reaction that tolerates many useful functional groups using the Ruppert-Prakash reagent (TMSCF3)followedby aromatization to deliver highly functionalized Ar–CF3 compounds in a one/ two-pot sequence. This general strategy enables access to highly substituted Ar–CF3-containing molecules that are difficult,expensive,and/or impossible to access by current synthetic methods. https://lnkd.in/gAaFtbuS

Can NaBH4 act as a reducing agent for esters? Check out the final chapter of my thesis, which explores the electrostatic templating abilities of short peptide nanotubes towards hydride-rich model cofactor NaBH4 for efficient ester reduction in water, published @Nature Communications (Nature Portfolio) Article Link: https://lnkd.in/gMZUz8Ya #Systemschemistry #Shortpeptides #Amyloid #Catalysis #Enzymemimics