Sampled’s Post

🧠 Dive into the world of Alzheimer’s biomarker research with Dr. Liu and Dr. Roberts. Discover how plasma p-Tau181 and p-Tau 217 are shaping the landscape of early detection and prognosis. https://lnkd.in/g662N74t #Alzheimers #Biomarkers

🧠 Dive into the world of Alzheimer’s biomarker research with Dr. Liu and Dr. Roberts. Discover how plasma p-Tau181 and p-Tau 217 are shaping the landscape of early detection and prognosis. https://lnkd.in/e2dpphfJ #Alzheimers #Biomarkers

Selection of October scientific NEWS. Exciting breakthrough in endometriosis research! 🔬A new study published in the journal Med has identified distinct stool metabolites in women with endometriosis, paving the way for non-invasive diagnosis and potential microbiota-based therapies. Key findings: • Unique bacteria-derived metabolite signature linked to endometriosis • Altered fecal metabolite profile similar to inflammatory bowel disease (IBD) • 4-hydroxyindole, a gut bacteria-derived metabolite, found to be lower in endometriosis patients • In vivo studies showed 4-hydroxyindole suppressed endometriosis-associated inflammation and pain. This groundbreaking research offers hope for faster diagnosis and new treatment options for the millions of women affected by endometriosis worldwide. Read the full paper: https://lnkd.in/ewQuBhZn #Endometriosis #WomensHealth #MedicalResearch #Microbiome #NonInvasiveDiagnostics

Indiana University School of Medicine researchers make an exciting discovery - unveiling a novel understanding of cell communication during inflammation, paving the way for potential new treatments for diseases like multiple sclerosis. By focusing on the signaling molecule STAT4, the team has revealed its critical role beyond T cells, in the central nervous system’s inflammatory responses. Discover more about how this discovery could lead to innovative therapeutic strategies. #healthcare #healthresearch #research #ms #iu #indiana #lifesciences

Clinicians with an interest in thrombophilia: Attend our next NBCA Journal Club session! The NBCA Journal Club highlights groundbreaking research in thrombosis and thrombophilia and features a manuscript author as part of the discussion. Our next session convenes June 18, 2024 from 2-3 p.m. ET to discuss, Antithrombin Therapy: Current State and Future Outlook, published in Clinical and Applied Thrombosis/Hemostasis in 2023. The paper’s author, George M. Rodgers, III, MD, PhD, Professor of Medicine in the Division of Hematology and Hematologic Malignancies at the University of Utah School of Medicine, will join us to discuss his research. The session’s learning objectives: - Understand the genetic and acquired factors contributing to antithrombin (AT) deficiency and its implications. - Explore current treatment strategies for managing AT deficiency. - Identify specific patient populations and use cases where AT therapy may be considered and evaluate its potential benefits. - Investigate advancements and future directions in research, diagnosis, and treatment approaches for AT deficiency to enhance clinical outcomes and patient care. Register: bit.ly/NBCAJournalClub2024 #stoptheclot #nbcajounalclub #bloodclots #thrombophilia #thrombosis #antithrombintherapy #antithrombindeficiency #bloodcloteducation #continuingeducation

This research by Alicia R. Lane, Noah E. Scher, Shatabdi Bhattacharjee, Stephanie A. Zlatic, and colleagues revolutionizes the development of human cardiac organoids (hCOs) by creating a novel maturation protocol that more closely mirrors the human heart's developmental journey. This protocol, termed "directed maturation" (DM-hCO), involves strategically activating AMPK and ERR signaling pathways, resulting in hCOs with enhanced functionality and metabolic properties. These DM-hCOs demonstrate a robust increase in mitochondrial respiration, a key hallmark of mature cardiac tissue. The study leverages the unique capabilities of #Resipher, allowing the use of standard cell culture media, to demonstrate that this enhanced mitochondrial respiration persists over multiple days, making it ideal for studying complex, long-term processes in the heart. This advancement paves the way for more realistic and physiologically relevant models for cardiac disease and drug discovery. In fact, the researchers successfully modeled desmoplakin cardiomyopathy, a challenging human genetic disease, and identified potential therapeutic strategies using this innovative DM-hCO model. This work represents a crucial leap forward in employing hCOs as robust tools for disease modeling and drug development. View it here: https://lnkd.in/dtWfQfVn #CardiacOrganoids #hCOs #CardiacDiseaseModeling #DrugDiscovery #Cardiomyopathy #MitochondrialRespiration #StemCellResearch

Exciting advancements in cardiac research! A new study by Alicia R. Lane and colleagues has introduced a groundbreaking maturation protocol for human cardiac organoids (hCOs) called "directed maturation" (DM-hCO). By activating specific signaling pathways, this approach significantly enhances the functionality and metabolic properties of hCOs, including improved mitochondrial respiration. Leveraging #Resipher's capabilities, the study enables the use of standard culture media while maintaining these enhancements over several days. This innovation not only provides more realistic models for cardiac disease and drug discovery but also successfully modeled desmoplakin cardiomyopathy, paving the way for potential therapeutic strategies. A major leap forward in our understanding of heart disease and treatment! Check out the full study here: https://lnkd.in/dtWfQfVn

Clinicians with an interest in thrombophilia: Attend our next NBCA Journal Club session! The NBCA Journal Club highlights groundbreaking research in thrombosis and thrombophilia and features a manuscript author as part of the discussion. Our next session convenes June 18, 2024 from 2-3 p.m. ET to discuss, "Antithrombin Therapy: Current State and Future Outlook," published in Clinical and Applied Thrombosis/Hemostasis in 2023. The paper’s author, George M. Rodgers, III, MD, PhD, Professor of Medicine in the Division of Hematology and Hematologic Malignancies at the University of Utah School of Medicine, will join us to discuss his research. The session’s learning objectives: - Understand the genetic and acquired factors contributing to antithrombin (AT) deficiency and its implications. - Explore current treatment strategies for managing AT deficiency. - Identify specific patient populations and use cases where AT therapy may be considered and evaluate its potential benefits. - Investigate advancements and future directions in research, diagnosis, and treatment approaches for AT deficiency to enhance clinical outcomes and patient care. Register: bit.ly/NBCAJournalClub2024 #stoptheclot #nbcajounalclub #bloodclots #thrombophilia #thrombosis #antithrombintherapy #antithrombindeficiency #bloodcloteducation #continuingeducation

🍏 Introducing Alexandra Mack, a researcher from the Department of Gastroenterology, working in Emma Halmos's group. Allie Mack's current research projects are on: Disorders of gut-brain interactions (DGBI) in patients with Crohn's disease, exploring their prevalence and the role of unresolved intestinal inflammation. A pilot study assessing the efficacy of transcutaneous vagal nerve stimulation (tVNS) in treating intestinal inflammation and barrier dysfunction in IBD patients. These pioneering projects aim to deepen our understanding of gut-brain interactions and develop innovative treatments for inflammatory bowel disease. Click through to learn more about Allie! 🌟 #ResearcherSpotlight #Gastroenterology #IBDResearch #GutBrainAxis #PhDJourney Monash Translational Medicine

Our Expert Roundtable with Illumina, Cardiovascular Medicine in the Genomics Era, is coming up this week! Join Clint Founder Rajesh Dash MD PhD and our distinguished panel: Dr. Joshua Knowles, Nicholas Marston, MD, MPH, and Dr. Mauro Longoni on May 9th, 2024, at 4:30 p.m. EST for an insightful roundtable discussion. They will address current hurdles and explore tactics for fostering fair access and widespread adoption of genetic testing in clinical settings. 🔍 Key Topics We'll Explore: - How genetic testing can enhance patient management and outcomes in cardiology. - Factors contributing to the underutilization of genetic testing. - Variability in the recommendation of genetic tests across cardiology clinics. - Supporting healthcare providers in the confident use of genetic tests. Strategies to encourage wider adoption of genetic testing in cardiology. You don’t want to miss it. Register today! https://lnkd.in/gh77pEfc