🌿 Exploring the impact of environmental factors on immune systems: A study published in Science Magazine, featuring research from SFI’s Andrea Graham and the team at Princeton University tracked rewilded laboratory mice in outdoor enclosures. Individual and social behaviors vary among mouse strains, highlighting the importance of shared spatiotemporal activity patterns. 🤝 The more two mice are associated, the more similar their immune profiles become. 🦠 🧬 Social interactions and activity play a crucial role in immune phenotypes. 🔗 https://lnkd.in/g-HSYNTw
Santa Fe Institute’s Post
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The complexity of MS certainly is going to require this type of big data analysis.
Sergio E. Baranzini, PhD, a geneticist, neuroimmunologist and data scientist at the University of California, San Francisco, is the winner of this year’s Barancik Prize for Innovation in MS Research. His pioneering efforts integrate vast pools of information (“Big Data”) to understand complex mechanisms that cause MS and to develop more precise approaches to stop the disease and end it by prevention. Prof. Baranzini’s work informs Pathways to MS Cures and he joins a distinguished group of previous recipients who are driving progress in high priority research questions. Congratulations, Prof. Baranzini!
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Human-centric approaches such as microphysiological systems and in silico methods have shown great promise in developing our understanding of human biology and disease, but can the use of these novel methods be wholly embraced within a prevailing research paradigm that has been both built upon and dominated by animal models? https://lnkd.in/gDH9Cd5Q Read the full article:
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Episode 4 of the R-Files is here. Longevity scientist Matt Kaeberlein discusses the results, methodology, and unanswered questions of research suggesting potential immune-boosting effects of rapamycin in mice and humans. https://lnkd.in/ghgc5kgR
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Dr. Doug Fowler and Dr. Sumaiya Iqbal reflect on the 2024 Mutational Scanning Symposium and offer suggestions for the 2025 event (Brotman Baty Institute Q&A out today!) Question: Did the symposium meet – or exceed – your expectations? Why? Dr. Iqbal: "Yes; it surely did! I recognized a nice balance in the number of talks focusing on non-coding and protein-coding MAVEs. A mix of computationally and experimentally focused works were also noticeable, and also talks diving deep into specific genes and diseases as well as the development and applications of large-scale resources such as ClinGen, MAVEdb and Genomics 2 Proteins portal." Dr. Fowler: "The symposium definitely exceeded my expectations. We had a great diversity of talks. This was the seventh annual symposium and it has become clear that the mutational scanning space has left its infancy and youth, and is emerging into adulthood. There now are all these amazing and mature applications of the technology and compelling stories in very different topic areas. This is reflective of the technology maturing to the point where people are now using technology to solve complex biological problems." Read the full piece on the BBI website! https://lnkd.in/g2TfDSft
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In our Grantee Spotlight Interviews, AFAR’s recent grantees share their vision for their AFAR-supported research, in their own words. This month, we are pleased to share Grantee Spotlight Interviews with the 2023 Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty recipients: The next recipient is Qinchuan Wang, PhD: On his 2023 Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty Award Dr. Wang, of The Johns Hopkins University explains: “My research interest lies at the intersection of basic biology, where nature's intricacies captivate me, and translational science, where I hope to bring tangible health benefits through my findings... Think of genes as individual chapters in the story of life. Some chapters (genes) are very similar from one species to another, including in humans. By changing certain chapters in these animals, we can see how it affects their aging process, such as becoming frail. Our ultimate goal is to understand this story better, hoping it can help us discover new ways to age healthily in humans.” Read more about what inspires Dr. Wang’s AFAR-supported research in his Grantee Spotlight interview here: https://ow.ly/43cH50RYxLx
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Featured on the cover of Cells, discover the groundbreaking research on Inflammasome-Dependent Dysfunction and Death of Retinal Ganglion Cells, featuring Dr. Valery Shestopalov and a team of Bascom Palmer esteemed researchers. Dive deep into the full article here: https://lnkd.in/edBfTdWA
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Executive Director, US Department Head, Cardiometabolic Diseases Research at Boehringer Ingelheim
Glad Eric Finnemore could share the innovative work on "Characterization of Three-Dimensional Engineered Muscle Tissue (EMT) System for Skeletal Muscle Disorder Research" at the New Directions in Biology and Disease of Skeletal Muscle Conference today!
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🔬✨ Breaking News: Scientists Unveil a Completely New Set of Blood Groups! 🅰️🅱️🆎🅾️ Prepare to be amazed by the latest groundbreaking discovery featured on The Quantified World. Scientists have revealed a revolutionary finding: a completely new set of blood groups that challenges our current understanding of human blood types. In this captivating article, we delve into the details of this remarkable breakthrough, exploring the implications for healthcare, transfusion medicine, and beyond. Join us as we unravel the mysteries of these newly identified blood groups and their potential impact on medical research and practice. Read the full article here to uncover the fascinating world of blood group discovery: Link to the article - https://lnkd.in/dzm3j-UJ Join the conversation and share your thoughts on this groundbreaking discovery. Let's celebrate the ingenuity of scientists and the endless possibilities of scientific exploration! #BloodGroups #MedicalResearch #ScientificDiscovery #TheQuantifiedWorld
Groundbreaking Discovery: Scientists Unveil a Completely New Set of Blood Groups
medium.com
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Bernie-Marcus Early-Career Professor of Biomedical Engineering at Georgia Institute of Technology
New PrePrint Alert! Spatial Morphoproteomic Features Predict Uniqueness of Immune Microarchitectures and Responses in Lymphoid Follicles Thomas Hu, Mayar Allam, Vikram Kaushik, Steven Goudy MD, MBA, Qin Xu, Pamela Mudd, Kalpana Manthiram, and Ahmet F Coskun https://lnkd.in/eTrNSE2U Did you know that the immune responses are akin to "SNOWFLAKES", uniquely shaped by antigens to form distinct shapes and spatial cell organization? Curious? Listen to a story on Science Cast https://lnkd.in/ejHwYHBh
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