Sartorius’ Post

🔬 Did you know that mitochondria, the powerhouse of our cells, are inherited from our mothers? These tiny organelles are not just crucial for our health but also play a significant role in cancer. Cancer cells rely on mitochondria for energy, especially in harsh environments where nutrients are scarce. Mitochondria help these cells by producing ATP, a more efficient energy source than glycolysis. This process is key for tumor growth and survival. Understanding the intricate dance between cancer cells and mitochondria is vital. It sheds light on how tumors resist drugs and continue to thrive. Learn more about the world of cellular energy and cancer resilience - download the infographic: https://ow.ly/lPIx50RQPp0 #CancerResearch #Mitochondria #CellBiology #DrugResistance #livecellimaging

What impact could you have on patient healthcare if you were to design a panel for liquid biopsy testing? At The Institute of Cancer Research, scientists designed a pan-cancer sequencing panel for liquid biopsy molecular diagnostics which could be used to profile tumor DNA in the blood of paediatric cancer patients. This opens up the possibility to routinely sample patients, monitoring their response to treatment and following their disease progression to detect relapse as early as possible. Read more in our blog post: https://bit.ly/3R08LK8 What panel would you design? Let us know in the comments. #thefutureisfluid #timematters #precisionmedicine #liquidbiopsy

In an incredible breakthrough in cancer research, a team of researchers from Asia has discovered a game-changing panel of genes that could revolutionise screening and monitoring for stomach cancer patients at high risk. “By combining both clinical information and genetic data from advanced molecular technologies, we can better predict which stomach conditions might turn into stomach cancer compared to only using clinical information," said Professor Patrick Tan, Senior Vice-Dean for Research at Duke-NUS. Read all about this exciting breakthrough from the link in the comments below. 📸: Alice Chia, Duke-NUS #DukeNUSMEDICUS #DukeNUS #stomach #cancer

HYPOXY: INTRIGUING FEATURE IN CANCER CELL BIOLOGY Hypoxia, a key aspect of the tumor microenvironment, plays a vital role in cell proliferation, angiogenesis, metabolism, and the immune response within tumors. These factors collectively promote tumor advancement, aggressiveness, metastasis and result in a poor prognosis. Hypoxia inducible factor 1α (HIF-1α), activated under low oxygen conditions, mediates many of these effects by altering drug target expression, metabolic regulation, and oxygen consumption. These changes promote cancer cell growth and survival. Hypoxic tumor cells develop aggressive traits and resistance to chemotherapy and radiotherapy, leading to increased mortality. Targeting hypoxic tumor offers a potential solution to overcome the challenges posed by tumor heterogeneity and can be used in designing diagnostic and therapeutic nanocarriers for various solid cancers. This concept provides an overview of the intricate relationship between hypoxia and the tumor microenvironment, highlighting its potential as a promising tool for cancer therapies. The article explores the development of hypoxia in cancer cells and its role in cancer progression, along with the latest advancements in hypoxia-triggered cancer treatment. #Hypoxia_Inducible_Factor_1α #HIF_1α #cancer #therapy #tumor_microenvironment

Researchers have discovered a potential mechanism underpinning why a person's genome might influence the subtype of breast cancer they develop. Dr Kathleen Houlahan, lead researcher in the study, commented, “Our findings not only explain which subtype of breast cancer an individual is likely to develop but they also hint at how aggressive and prone to metastasising that subtype will be.” Hannah Flynn and Yan Lau write about this important research in BioNews: https://lnkd.in/eNcXr2WW Why not share your thoughts in the article comment section on our website. #breastcancer #cancer #BRCA1 #BRCA2 #cancerresearch #genomics #genetics #DNA

AD | Our 2023 paper “Plasma proteome of growing tumors,” in Nature Scientific Reports is one of their Top 100 cancer papers downloaded in 2023. The paper outlined the need for a simple and reliable blood screening for the early detection of #cancer.   The research team, led by authors at SomaLogic and the University of Colorado School of Medicine, described using the SomaScan® Platform to find 15 protein #biomarkers shared by all cancer types and detailed how they developed models to stratify tumor types and identify unique biological pathways of tumor cell lines.   Nature published nearly 1,400 papers on cancer in 2023 and we’re happy that our #proteomics work is sparking conversations in #cancerresearch! Read the paper here: https://lnkd.in/gzA8yEus

What drives IDH-mutated gliomas? What are their therapeutic vulnerabilities? These are the questions underlying the research of Chunzhang (Spring) Yang, Ph.D., head of the Neuro-Oncology Branch Molecular and Cellular Research Program. 🧠 Though IDH mutations spur some cells to become cancerous, patients with IDH-mutated gliomas tend to have better outcomes, indicating it may make tumors more responsive to treatment. National Cancer Institute (NCI) ➡ Learn more: go.cancer.gov/GFDg3uQ

Today I would like to highlight Rho GTPases in Cancer. These tiny cellular switches play a pivotal role in orchestrating cell movement, shape, and communication. In the world of cancer biology, Rho GTPases have become intriguing characters, influencing processes like cell migration and invasion—crucial in the progression of many cancers. Unravelling their intricacies provides a deeper understanding of the molecular mechanisms behind tumorigenesis. Yet, like complex characters in a scientific drama, Rho GTPases can have dual roles. While some members promote cancer progression, others exhibit tumour-suppressive qualities. Navigating this intricate balance unveils potential avenues for therapeutic interventions. #CancerBiology #RhoGTPases

Delighted to announce our next publication titled: "GLUT and HK: Two Primary and Essential Key Players in Tumor Glycolysis" in Seminars in Cancer Biology (Impact factor-15). Our study delves deep into the intricate mechanisms of tumor glycolysis, shedding light on the pivotal roles played by GLUT and HK proteins. Through rigorous investigation, we uncover crucial insights that could revolutionize cancer treatment strategies. For those interested in exploring the complexities of tumor metabolism and its implications for cancer therapy, this article is a must-read. DOI- 10.1016/j.semcancer.2024.03.001 Gratitude and best wishes to all the co-authors and Prof. Vinit Kumar for guiding us. #CancerResearch #TumorGlycolysis #ScientificPublication #GLUT #HK #SeminarsinCancerBiology #ScientificDiscovery

The idea behind this study goes back to 2015, when I asked whether the APOBEC mutations had a mutagenic impact similar to APOBEC mRNA levels. The multivariate model that was used ended up with some surprising findings, suggesting that APOBEC1 mediates the aging impacts on the cancer genome, while ADARB1 mediates some UV mutagenic impacts, both acting as endogenous mutators. APOBEC/ADAR mutations were also found to potentiate some DNA repair defect impacts on the cancer genome. https://lnkd.in/d_Dt-Hw6 #mutational_signature #APOBEC1 #ADARB1 #cancer