Science-Switzerland’s Post

🎉 India's Milestone Achievement in Genomics 🎉 Human genome sequencing is more than just mapping out DNA; it's about unlocking the code of life itself. This process allows scientists to dive deep into the genetic instructions that make up a human being, offering insights into how genes interact, influence our health, and are passed down through generations. India's achievement in sequencing 10,000 human genomes is a monumental step forward in the global endeavor to understand human genetics. It not only contributes to a global understanding but also emphasizes the need for a India-specific genetic database to address unique healthcare challenges. This accomplishment is a beacon of hope for personalized medicine, promising a future where treatments and medications are tailored to the genetic makeup of individuals, minimizing risks and maximizing efficacy. Let's applaud the researchers and everyone involved in the Genome India project for their dedication and hard work. Here's to more breakthroughs and advancements in the field of genomics! #GenomeIndia #HumanGenomeSequencing #personalizedmedicine #genomics #healthcareinnovations #cellandgenetherapy https://lnkd.in/gZPMxCzK

https://lnkd.in/e_KZyrFS Was the evolution guided by a helping hand to move humanity to the next state?, is a question many a philosophers, scientists and like have had for generations. It seems evolution is orderly and most probably contrary to popular scientific belief. In a landmark discovery that challenges decades of scientific understanding, a new study has revealed that evolution is not as random as previously believed. The research suggests a more predictable pattern of evolution, opening doors to unprecedented advancements in various fields, including medicine, synthetic biology, and environmental science leading to a more cohesive, comprehensive and single strategy approach for myriad of scientific domains. The experts meticulously analyzed the pangenome — a complete set of genes within a species. By deploying a machine learning technique known as Random Forest, and processing data from 2,500 complete genomes of a single bacterial species, the team embarked on a journey to unravel the mysteries of evolutionary predictability. “The implications of this research are nothing short of revolutionary,” said Professor McInerney, the lead author of the study. “By demonstrating that evolution is not as random as we once thought, we’ve opened the door to an array of possibilities in synthetic biology, medicine, and environmental science.” The research process involved creating “gene families” from the genomes to facilitate like-for-like comparisons across them. The researchers have essentially discovered an invisible ecosystem where genes can cooperate or can be in conflict with one another. These interactions between genes make aspects of evolution somewhat predictable and furthermore, we now have a tool that allows us to make those predictions. In summary, this important research presents significant opportunities in several fields. Scientists are now capable of designing synthetic genomes, which provides a structured approach to manipulating genetic material, a breakthrough in novel genome design. Additionally, the study offers valuable insights for climate change mitigation. It suggests the possibility of engineering microorganisms to either capture carbon or degrade pollutants. Lastly, in the medical field, the predictability of gene interactions could lead to substantial advancements in personalized medicine. #syntheticbiology #healthcarecosts #climatechange #proteinmapping

https://lnkd.in/gzTcKdxw 🔬 Exciting news in the world of genomics! The UK Biobank has taken a monumental leap forward by releasing the complete genome sequences of 500,000 British volunteers. This landmark development, as reported in Nature on November 30, 2023, represents the largest set of full human genome sequences made accessible to the global research community. 🧬 Why This Matters: This comprehensive dataset goes beyond the previously available genetic information by including whole genomes. This allows for an in-depth exploration of rare genetic variants, which are crucial for understanding complex diseases and traits. A recent study, utilizing the initial 200,000 genomes, identified novel DNA variants influencing height – a glimpse of the potential this database holds. 🌐 Global Impact: The release of these genome sequences marks a significant step towards personalized medicine. By enabling the study of rare variants, scientists can gain deeper insights into human biology and the genetic basis of diseases. This resource is not just for the UK; it’s a global treasure that will advance medical research worldwide. 🔍 Looking Ahead: While this is a giant leap, researchers like Michael Weedon from the University of Exeter believe that even more genomes will be necessary to comprehensively map the associations between rare gene variants and health. Projects like the All of Us study in the US complement this effort by aiming to release genome and health data from over a million people. 🤝 Collaboration Is Key: The UK Biobank's initiative underscores the importance of large-scale, collaborative efforts in genomic research. It's a reminder that when we pool resources and knowledge, the possibilities for discovery and innovation in healthcare are limitless. 💡 A Bright Future for Genomics: The full impact of this dataset may take time to unfold, but one thing is certain – it opens up new horizons for understanding human health and developing targeted treatments. Let’s celebrate this pivotal moment in genomics! The future of personalized healthcare just got brighter, thanks to the UK Biobank's commitment to open, collaborative science. #Genomics #UKBiobank #PersonalizedMedicine #HealthcareInnovation #ScientificResearch

Why molecular research in butterflies? Some might see them as simply ornamental creatures, but in research, they play a crucial role in understanding evolutionary mechanisms. Certain butterflies reveal variations in patterns among populations, making them prime targets for gene-wide association studies that uncover evolutionary genomic hotspots. Ever wondered how these hotspots function and evolve? Me too! CRISPR-Cas9 really made this possible. Scientist were finally able to look at the genomic data on the computer screen and mutate it in a living organism to see if they work or are they noise - there is a lot of noise in biology. The advantage of the butterfly wing is that you see the result in-vivo in a single life cycle from caterpillar to grown butterfly. The CRISPR perturbation assays are interpreted as changes in a single wing scale-cell; they reveal themselves as a clonal mosaic aberration on the wing. Much like different colored tiles cutting through an otherwise generic brown clay tile roof. #TLDR I sit here reflecting on how best to attract attention to my CV. I wonder if recruiters in the tech industry truly grasp the profound insights this research offers on disease processes such as cell identity, gene regulation, and as we discovered - non-coding RNA elements. I believe this field offers deep value in the general understanding of molecular - health related mechanisms.

If we only conduct genomics research with human populations of European descent, we will limit our ability to use genomics for benefiting everyone. That is why there are efforts around the world to capture more human diversity in genomics studies. One important example is All of Us Research!    All of Us Research has updated its genomics dataset to include over 245,000 clinical-grade human genome sequences, half of whom identify with groups historically underrepresented in biomedical research. From these data, they have found 275 million previously undiscovered genomic variants! These efforts will help researchers and healthcare providers better understand the genomic influences of health and disease, especially in communities who have historically been understudied. I encourage you to read more about this important research and exciting new findings! https://lnkd.in/e-_hmXXR

April 25th commemorates 𝐍𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐃𝐍𝐀 𝐃𝐚𝐲, a day of absolute significance in the realm of genetics and molecular biology. 𝑩𝒖𝒕 𝒘𝒉𝒚 𝑨𝒑𝒓𝒊𝒍 25𝒕𝒉? It marks the anniversary of the groundbreaking discovery of DNA's double helix structure in 𝟏𝟗𝟓𝟑 by James Watson and Francis Crick, as well as the completion of the Human Genome Project in 𝟐𝟎𝟎𝟑. These milestones paved the way for revolutionary advancements in our understanding of genetics and its applications. Recent developments continue to push the boundaries of DNA research. From CRISPR gene editing technology to personalized medicine, we're witnessing a remarkable era of innovation. The ability to sequence DNA has become increasingly accessible, leading to unprecedented insights into human health, ancestry, and biodiversity. Statistics reveal the notable impact of DNA sequencing: over 𝟑𝟖 𝐦𝐢𝐥𝐥𝐢𝐨𝐧 consumer DNA tests have been conducted worldwide, aiding in genealogical research, health risk assessment, and personalized medicine. 𝑀𝑜𝑟𝑒𝑜𝑣𝑒𝑟, 𝑎𝑠 𝑝𝑒𝑟 𝐼𝑛𝑘𝑤𝑜𝑜𝑑 𝑅𝑒𝑠𝑒𝑎𝑟𝑐ℎ, 𝑡ℎ𝑒 𝑔𝑙𝑜𝑏𝑎𝑙 𝐷𝑁𝐴 𝑠𝑒𝑞𝑢𝑒𝑛𝑐𝑖𝑛𝑔 𝑚𝑎𝑟𝑘𝑒𝑡 𝑖𝑠 𝑝𝑟𝑜𝑗𝑒𝑐𝑡𝑒𝑑 𝑡𝑜 𝑟𝑒𝑎𝑐ℎ $𝟑𝟓𝟐𝟖𝟐.𝟕 𝑚𝑖𝑙𝑙𝑖𝑜𝑛 𝑏𝑦 𝟐𝟎𝟐𝟖, ℎ𝑖𝑔ℎ𝑙𝑖𝑔ℎ𝑡𝑖𝑛𝑔 𝑖𝑡𝑠 𝑔𝑟𝑜𝑤𝑖𝑛𝑔 𝑖𝑚𝑝𝑜𝑟𝑡𝑎𝑛𝑐𝑒 𝑎𝑐𝑟𝑜𝑠𝑠 𝑖𝑛𝑑𝑢𝑠𝑡𝑟𝑖𝑒𝑠. DNA sequencing holds immense promise in various fields. For instance, in healthcare, it facilitates early disease detection, targeted therapies, and drug development. On the other hand, while DNA sequencing in agriculture enhances crop yield and resilience to climate change, in forensic science, it aids in solving crimes and identifying missing persons. This National DNA Day, gain in-depth insights on the global DNA sequencing market forecast by referring to our comprehensive report summary here: https://lnkd.in/dyfvRiN6 . . . Adaptive Biotechnologies Corp. Agilent Technologies Asuragen BGI Genomics #nationaldnaday #dnasequencing #dnatest #healthcare #biotechnology #genetics #marketanalysis #inkwoodresearch

𝐁𝐫𝐢𝐞𝐟 𝐚𝐛𝐨𝐮𝐭 𝐆𝐞𝐧𝐨𝐦𝐞 𝐦𝐚𝐩𝐩𝐢𝐧𝐠 Genome mapping is a crucial technique in genetics and molecular biology that involves identifying the location of genes and other genetic elements on a chromosome. By mapping an organism's genome, scientists can better understand the #genetic makeup of an individual or a species, including the arrangement of genes, variations, and regulatory elements. This information is invaluable for studying genetic diseases, evolutionary relationships, and various #biological processes. 𝐂𝐥𝐢𝐜𝐤 𝐇𝐞𝐫𝐞 𝐭𝐨 𝐆𝐞𝐭 𝐅𝐫𝐞𝐞 𝐏𝐃𝐅 𝐁𝐫𝐨𝐜𝐡𝐮𝐫𝐞- https://lnkd.in/gtyfprkf One of the recent advancements in genome mapping is the field of spatial genomics. Spatial genomics focuses on understanding the three-dimensional organization of the genome within the cell nucleus and how this organization influences gene expression and cellular functions. Traditional genome mapping techniques, such as sequencing and genetic mapping, provide information about the linear sequence of DNA bases along a #chromosome. However, spatial genomics goes a step further by revealing how this linear sequence is folded and organized in the three-dimensional space of the nucleus. Spatial genomics techniques, such as chromosome conformation capture (3C) and its derivatives (4C, 5C, Hi-C), allow scientists to investigate the physical interactions between distant regions of the genome. These techniques provide insights into how genes are spatially positioned relative to each other, how regulatory elements interact with target genes, and how chromatin architecture influences gene expression patterns. Spatial genomics has revolutionized our understanding of gene regulation, cell differentiation, development, and disease. By integrating spatial genomics data with traditional genomic information, researchers can create comprehensive maps that provide a more holistic view of the genome. This integrated approach is advancing our understanding of complex biological processes and diseases, paving the way for personalized #medicine, targeted therapies, and precision genetic engineering. Spatial genomics is a powerful tool that complements traditional genome mapping techniques, offering insights into the spatial organization of the genome and its functional implications. This interdisciplinary field is shaping the future of genetics and genomics research, with profound implications for human #health and biology. #Genomemapping #genomeediting #spatialgenomics #genome #future #medical #innovation 

Are you part of "All of Us"?🧑🏿🤝🧑🏻🧑🏼🤝🧑🏻 Six years ago, the National Institutes of Health launched a large precision medicine study called “All of Us.” The aim was to gather data from over 1 million people to uncover new genetic information. 𝗪𝗵𝘆 𝘀𝗵𝗼𝘂𝗹𝗱 𝘆𝗼𝘂 𝗸𝗻𝗼𝘄❓ 1. The project aims to address the diversity issue in genomic data (predominantly European) and improve understanding of disease biology. 2. It applies a “data passport” model to provide easy access to data to researchers. 3. It is looking for continued support and funding to reach the goal of sequencing 1 million genomes by 2026. 𝗪𝗵𝗲𝗿𝗲 𝗱𝗶𝗱 𝗶𝘁 𝗴𝗲𝘁 𝘁𝗼⚙️ - It has released nearly 250,000 whole genome sequences recently, half of which are from non-European ancestries. - The “data passport” model has attracted nearly 7,000 scientists from diverse institutions. - The data have led to the development of more accurate risk scores for common diseases across different ethnic backgrounds. 👉🏻 𝗪𝗼𝘂𝗹𝗱 𝘆𝗼𝘂 𝗴𝗶𝘃𝗲 𝘆𝗼𝘂𝗿 𝗯𝗹𝗼𝗼𝗱, 𝘀𝗽𝗶𝘁 𝗮𝗻𝗱 𝗽𝗲𝗲 𝘁𝗼 𝘁𝗵𝗲 𝗽𝗿𝗼𝗷𝗲𝗰𝘁? Investment theme: Genetic Therapies - Source: STAT #investing #genetics #health Thematic #investment #Litrendingtopics PS: Did you know that the majority of genome studies were conducted with data from people from just three countries: UK, US and Iceland? (Source: Nature)

Celebrating 21 Years of the Human Genome Project! A Milestone in Scientific and Medical History This month marks 21 years since the completion of the Human Genome Project, an unprecedented initiative that set out to decipher the complete code of human DNA. Between 1990 and 2003, scientists from around the world united in this titanic effort, successfully sequencing 92% of the human genome. However, the journey was not without its challenges. Certain regions of the genome, complex and repetitive, resisted being deciphered. But the determination of the scientific community did not waver. In 2022, the complete sequencing of the human genome was finally achieved, filling in the remaining gaps and opening a new chapter in our understanding of our own biology. The impact of the Human Genome Project has been profound and lasting: -Personalized medicine: Individual genetic information now allows doctors to develop personalized and more effective treatments for a wide range of diseases. -Diagnosis of rare diseases: Knowledge of the human genome facilitates accurate diagnosis of rare genetic diseases, enabling better management and care for patients. -Understanding of evolution: Analysis of the human genome has provided invaluable information about human evolution and our relationship to other species. -New areas of research: The Human Genome Project has driven the development of new technologies and areas of research in biomedicine, such as epigenetics and functional genomics. Without a doubt, the Human Genome Project has been a fundamental milestone in the history of science, paving the way for a healthier future and a better understanding of human life. #HumanGenomeProject #Science #Medicine #Genetics #Health Additional resources: https://lnkd.in/e-N4f_p https://lnkd.in/gYhdBHRC https://lnkd.in/du6-zgJR

Britain’s genomics landscape and 10 exciting businesses to watch 🔬 Britain is a large player in the global genomics field. With a rich history of scientific discoveries, the genomics sector in the UK continues to grow. In this article, we take a look at how and where innovation and growth is occurring for the British genomics industry, and take a deeper look into 10 exciting businesses that are taking the sector by storm: https://lnkd.in/eJTWweZ6 #genomics #business #UK