International SCN8A Alliance’s Post

NeuroRestore– with a focus on Alzheimer’s NeuroRestore is a platform of symptomatic drug candidates for diseases where cognitive ability is impaired, such as Alzheimer’s. NeuroRestore stimulates several important signal pathways in the brain, which among other things leads to improved cognition. In preclinical studies with NeuroRestore, we have been able to demonstrate that our drug compounds not only boost communication between nerve cells but also improve cognitive ability. The drug candidates in NeuroRestore stimulate signaling of neurotrophins, the most well-known of which is Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF). These neurotrophins are important for maintaining nerve cell function and communication, which are impaired with cognitive disorders. BDNF plays an important role for nerve cell function and communication in the areas of the brain that are essential for our cognitive ability, such as the hippocampus, located in the temporal lobe. Read and learn about our platforms at: https://lnkd.in/gh4DBrP #alzecure #Neurorestore #BDNF #redeye #alzheimerfonden #avanza #nordnet #edisongroup #seb #swedbank #nordea #aktiespararna #privataaffarer #vatorsecurities #finwire #erikpenserbank #alzehimersdisease #cognitivedisorders

NeuroRestore– with a focus on Alzheimer’s NeuroRestore is a platform of symptomatic drug candidates for diseases where cognitive ability is impaired, such as Alzheimer’s. NeuroRestore stimulates several important signal pathways in the brain, which among other things leads to improved memory and learning capabilities. In preclinical studies with NeuroRestore, we have been able to demonstrate that our drug compounds not only boost communication between nerve cells and improve cognitive ability. The drug candidates in NeuroRestore stimulate signaling of neurotrophins, the most well-known of which is Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF). These neurotrophins are important for maintaining nerve cell function and communication, which are impaired with cognitive disorders. BDNF plays an important role for nerve cell function and communication in the areas of the brain that are essential for our cognitive ability, such as the hippocampus, located in the temporal lobe. Read and learn about our platforms at: https://lnkd.in/gh4DBrP #alzecure #Neurorestore #BDNF #redeye #alzheimerfonden #avanza #nordnet #edisongroup #seb #swedbank #nordea #aktiespararna #privataaffarer #vatorsecurities #finwire #erikpenserbank #alzehimersdisease #cognitivedisorders

#neurodegeneration #CX3CL1 #age Exploration of C-terminal CX3CL1 for reducing age-dependent neurodegeneration https://lnkd.in/g9tpiqT5

Sudden Unexpected Death in Epilepsy (SUDEP) remains a critical concern in epilepsy management, with the underlying mechanisms still not fully understood. This blog delves into a fascinating study by Iyer, S., et al (2024) that investigates how altered ventilatory responses to hypercapnia-hypoxia (HH) challenges in a preclinical SUDEP model implicate orexin neurons: https://hubs.ly/Q02GWBTM0 #SUDEP #Orexins #Plethysmography #NeuralControlOfBreathing

📢🔟 SynapCell celebrates today the ten-year anniversary of its partnership with the University of Utah as the prime contract testing site of the National Institute of Neurological Disorders and Stroke (NINDS) #Epilepsy Therapy Screening Program (ETSP). NINDS is part of the National Institutes of Health. 👉This partnership represents a long-lasting and trustworthy collaboration with the University of Utah and the Anticonvulsant Drug Development (ADD) Program led by Prof. Karen Wilcox. SynapCell and the ADD Program work together in revealing the #antiseizure potential of novel compounds, with a focus on refractory epilepsies affecting millions of people worldwide. 💊Every new anticonvulsant introduced to clinical use in the USA during the past 40 years has been evaluated in this ADD research program. 👉Read the press release to learn more : https://lnkd.in/eu5jSgac Karen Wilcox, Cameron S. Metcalf, PhD, Corinne Roucard, Nicolas Vautrelle #epilepsy #focalepilepsy #MTLE #drugdiscovery #CNS #neurosciences 

Neurogenesis is the process by which new neurons are generated and integrated into the CNS. Neurogenesis occurs in a substantial subpopulation of the hippocampus, with new neurons comprising around one-third of the total number of hippocampal cells.

A new study sheds light on the complex process of turning non-neuronal cells into functional neurons. This approach, called direct neuronal reprogramming, holds promise for treating neurological disorders caused by neuron loss. Researchers identified key mechanisms involved in this cellular transformation, bringing us closer to potential therapies. #TalentInfluencersLeaderboard #FortreaAlwaysOn https://lnkd.in/dfb66byQ

A recent study published on Huntington's disease highlights the potential of an amphiphilic peptide to combat the oligomer assembly process of mutant Huntingtin (mHtt). Using the ISS Q2 Modular Confocal Microscope for FLIM measurements, researchers achieved nanoscopic insights into how this peptide targets mHtt early, transforming and suppressing its aggregation. This innovative approach not only reduces neurological damage but also rescues memory deficits in HD models through intranasal administration. Explore how this biophotonic platform is revolutionizing therapeutic design for neurodegenerative disorders! Read the full publication here: https://lnkd.in/gSbiQq2f Find out more about the Q2 System: https://lnkd.in/gsjJ4hun #HuntingtonsDisease #Neurodegeneration #ScientificResearch #FLIM #FFS #Biophotonics #ISS #InnovationInScience #TherapeuticDevelopment #confocalmicroscope

Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells https://lnkd.in/e_JmXygj

The study and treatment of microglia in neurological illness is so important https://lnkd.in/ede5D-A4