International SCN8A Alliance’s Post

🔬 Insights into Optimal First-Line Seizure Medications for SCN8A from our recently published global modified Delphi consensus  Here, we highlight the optimal first-line treatments for those with seizures and Loss of Function (LOF) SCN8A variants. This graphic documents the first-line, most often effective treatments: Valproate, Ethosuximide, and Lamotrigine and advises caution with most Sodium Channel Blockers.   For more info about the newly published consensus and more practical insights on SCN8A, tailored for both families and clinicians, visit scn8aalliance.org.  #scn8a #scn8aawareness #scn8astrong #thisisscn8a #curescn8a #scn8aresearch #scn8aalliance #ndds #DEEs #neurodevelopmentaldisorders #clinicalresearch #clinicalcare

#Myelodysplasticsyndrome phase III trial findings reported on #Heme Today: For pts with non-transfusion-dependent #MDS with #chromosome5q deletion, early #lenalidomide use can delay onset of dependency and improve tx response https://lnkd.in/eWjNvu2C

#Myelodysplasticsyndrome phase III trial findings: Using #lenalidomide early can delay onset of dependency and improve tx response in pts with non-transfusion-dependent #MDS with #chromosome5q deletion #Heme https://lnkd.in/eWjNvu2C

Better quality #RNA. Better #experiments. Explore the benefits of CatPure labeled #mRNA and order here: https://lnkd.in/eiuqm3_a #labeledRNA #research #egfp #celltherapy #genetherapy #transfection #qualitycontrol #qualityassurance

Cardamyst for PSVT Paroxysmal supraventricular tachycardia (PSVT) is a type of abnormal heart rhythm that involves sudden episodes of fast heartbeats. The episodes are unpredictable, coming on quickly and lasting minutes to several hours. Oftentimes, people need to go to the ER for treatment. But with Cardamyst (etripamil), people may be able to manage PSVT episodes themselves at home. Cardamyst is a fast-acting calcium channel blocker that’s administered as a nasal spray. During clinical studies, the medication (given as single or repeat doses) was able to significantly restore normal heart rhythm within 30 minutes. If approved, Cardamyst could help reduce trips to the ER and improve the quality of life for people with #PSVT. An FDA response on #Cardamyst for PSVT is expected by March 27, 2025.

Preliminary data from a study on CN201, a new CD3xCD19 IgG4 bispecific antibody, in adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia, indicates a duration of response up to 8 months. The treatment has shown manageable cytokine release syndrome (CRS) and no instances of immune effector cell-associated neurotoxicity syndrome (ICANS). Unlock In-Depth Expert Insights and Analysis with DelveInsight Business Research LLP's Exclusive ASCO 2024 Reporting! https://lnkd.in/gB5Fn6iD #ASCO24 #CancerTreatment #ASCO2024 #LungCancer #NSCLC #PharmaInnovation #MedicalResearch #OncologyAdvancements #ClinicalOncology #Pharmaceuticals #HealthcareConference #CancerResearch #ClinicalPractice #MedicalBreakthroughs #CancerCare #PharmaLeaders

SWS Medical SWS-5000 series CRRT (continuous renal replacement therapy is in international advanced position, it has the most treatment mode and indication scope among equivalent equipment, also the FIRST "First Set of Major Technological Equipment" in blood purification industry! #dialysis #dialysismachine #hemodialysis #hemodialysismachine #renalcare #kidneydisease #AKI #accutekidneyinjury #CRF #chronicrenalfailure #CRRT #continuousrenalreplacementtherapy #medicaldevice

There is a lot of hype now around drug-coated balloon, including its use in #complexPCI and #CTOpci. We have done #DCBonly in #CTOpci since 2012 in our institution. The first case was an 80yrs old patient at high bleeding risk (OAC). The RCA CTO was antegradely wired with CP12 and predilated with a 3.5mm balloon. Two #Sequentplease DCBs (3.5x30mm) were used. Only one-month SINGLE antiplatelet treatment was prescribed (clopidogrel). Control angio 2 years later showed nice positive vessel remodeling. The other case shown here was a 55yrs old patient on OAC. The RCA CTO was antegradely wired with Pilot150 and predilated with a 3.0mm balloon. Three #Sequentplease DCBs (one 3.0x33mm and two 2.75x26mm) were used. The patient had angio 8 yrs later showing an excellent long-term result. In our experience the #leavingnothingbehind approach is a good option in #CTOpci after intraplaque wiring in case the lesion does not need mechanical support but just the antiproliferative drug. Especially, long lesions, diffuse disease, bifurcations and high bleeding risk patients are intriguing targets for #DCBonly PCI. #siunsote #uef

We’re supporting development of tranexamic acid (TXA) in intramuscular (IM) formulation from MACH32 to potentially treat uncontrolled hemorrhage under our RePAIR program.️ During a mass casualty incident, people will have traumatic injuries, including internal bleeding. TXA prevents blood clots from being broken down, which slows the bleeding until the patient can be fully treated. TXA is currently FDA-approved in intravenous formulation, which is more challenging to use in the pre-hospital space and in emergency situations. In IM form, TXA could be administered faster. If successful, TXA could be integrated into routine emergency care for traumatic injuries. This would allow EMS and first responders to be more familiar with the product, and ensure the treatment is immediately available during emergencies, so patients can be treated quicker and more effectively. Learn more about this award: https://lnkd.in/dYxD4sRa

Phase 2a trial results suggest investigational weight-loss agent HU6 has mixed benefits for obesity-related HFpEF: https://lnkd.in/gis-CHUc