International SCN8A Alliance’s Post

🔬 Insights into Optimal First-Line Seizure Medications for SCN8A from our recently published global modified Delphi consensus  Here, we highlight the optimal first-line treatments for those with seizures and Loss of Function (LOF) SCN8A variants. This graphic documents to first-line, most often effective treatments: Valproate, Ethosuximide, and Lamotrigine and advises caution with most Sodium Channel Blockers.   For more info about the newly published consensus and more practical insights on SCN8A, tailored for both families and clinicians, visit scn8aalliance.org.  #scn8a #scn8aawareness #scn8astrong #thisisscn8a #curescn8a #scn8aresearch #scn8aalliance #ndds #DEEs #neurodevelopmentaldisorders #clinicalresearch #clinicalcare

#Myelodysplasticsyndrome phase III trial findings reported on #Heme Today: For pts with non-transfusion-dependent #MDS with #chromosome5q deletion, early #lenalidomide use can delay onset of dependency and improve tx response https://lnkd.in/eWjNvu2C

#Myelodysplasticsyndrome phase III trial findings: Using #lenalidomide early can delay onset of dependency and improve tx response in pts with non-transfusion-dependent #MDS with #chromosome5q deletion #Heme https://lnkd.in/eWjNvu2C

Preliminary data from a study on CN201, a new CD3xCD19 IgG4 bispecific antibody, in adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia, indicates a duration of response up to 8 months. The treatment has shown manageable cytokine release syndrome (CRS) and no instances of immune effector cell-associated neurotoxicity syndrome (ICANS). Unlock In-Depth Expert Insights and Analysis with DelveInsight Business Research LLP's Exclusive ASCO 2024 Reporting! https://lnkd.in/gB5Fn6iD #ASCO24 #CancerTreatment #ASCO2024 #LungCancer #NSCLC #PharmaInnovation #MedicalResearch #OncologyAdvancements #ClinicalOncology #Pharmaceuticals #HealthcareConference #CancerResearch #ClinicalPractice #MedicalBreakthroughs #CancerCare #PharmaLeaders

SWS Medical SWS-5000 series CRRT (continuous renal replacement therapy is in international advanced position, it has the most treatment mode and indication scope among equivalent equipment, also the FIRST "First Set of Major Technological Equipment" in blood purification industry! #dialysis #dialysismachine #hemodialysis #hemodialysismachine #renalcare #kidneydisease #AKI #accutekidneyinjury #CRF #chronicrenalfailure #CRRT #continuousrenalreplacementtherapy #medicaldevice

Phase 2a trial results suggest investigational weight-loss agent HU6 has mixed benefits for obesity-related HFpEF: https://lnkd.in/gis-CHUc

Run ELISpot on whole blood samples! Assessing antigen-specific T-cell responses can be challenging when isolating PBMCs is not practical or available. Our R&D team investigated using RBC lysis as a convenient approach for running ELISpot. We found that RBC lysis of whole blood can effectively be used to measure specific CD4 and/or CD8 T-cell responses in whole blood using the IFN-γ ELISpot. This approach significantly reduces handling time and can be implemented when PBMC analysis isn’t available. Check out our step-by-step protocol to implement it in your lab! https://hubs.li/Q02dtfhB0 #Tcellresponses #RBClysis #ELISpot #LabTips

Serum free medium QBSF-60 successfully supported ex vivo expansion and engraftment capability of human hematopoietic #stemcells (https://lnkd.in/efbMf4xi) #stemcellresearch bit.ly/3Ji8LSe

Daily Critical Care Pearls #216: Vasoconstriction in Septic Shock The pros and cons of vasoconstriction in septic shock are depicted in the below figure 👇👇 The impact may vary according to the time of administration (early vs. late) and type and dose of vasopressor agent. It may also be affected by the density and sensitivity of vasopressor receptors. While restoring MAP is the first goal of vasopressor therapy, vasopressors use is also associated with beneficial effects on venous reservoir and usually on organ perfusion. Nertheless, excessive vasoconstriction should be avoided, and other resuscitation strategies should not be neglected. #criticalcare #clinicalpharmacy #medicine #pearls

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