Sebia EMEA Export’s Post

🚀 Explore the EAE Model Based on IL7A Humanized Mice Recently approved IL-17A-targeting drugs for plaque psoriasis highlight the growing interest in IL-17A. Beyond its use in treating psoriasis, IL-17A is also drawing significant research interest in the field of autoimmune diseases. Our Experimental Autoimmune Encephalomyelitis (EAE) model, developed using our humanized IL17A mice (B-hIL17A), is a vital tool for studying the mechanisms of multiple sclerosis (MS) and other autoimmune diseases, providing a valuable resource for developing new therapies. In addition to the EAE model, Biocytogen's B-hIL17A mice are also ideal for establishing psoriasis models, making them versatile for various research applications. Contact us today in advancing your autoimmune research ! #AutoimmuneResearch #EAEModel #IL17A #Biocytogen #MSResearch #BiotechInnovation

EMA recommends non-renewal of authorisation of Duchenne muscular dystrophy medicine Translarna EMA's human medicines committee has recommended not renewing the conditional marketing authorisation for Translarna, a medicine for treating patients with Duchenne muscular dystrophy. Therefore the Committee recommended not renewing Translarna's marketing authorisation in the EU. This means that if this recommendation is confirmed by the European Commission, the medicine will no longer be authorised in the EU. Until then the marketing authorisation for Translarna remains valid in the EU. If you have any questions, you may contact your national competent authority. Translarna received a conditional marketing authorisation in the EU on 31 July 2014 for the treatment of patients with Duchenne muscular dystrophy whose disease is caused by a 'nonsense mutation' in the dystrophin gene. https://lnkd.in/eTurEdpq #PublicHealth #Europe #StayInformed #StayEmpowered

Genekam und its largest innovative solutions for Influenza H5N1 Virus Daily there are news of the spread of the #influenzavirus H5N1 in different parts of the world, particularly among the cows and human infections in #USA along with many other countries like #Egypt. It is time to prepare for the outbreak, which can be very painful and has the devasting effects. #Genekam Biotechnology AG has been working in this field for the last 20 years and served many countries with its solution. It has one of the largest solutions for influenzaviruses because it has developed 85 different tests, binding receptor differentiation solutions, potential therapeutic antibodies, potential therapeutic molecules, magnetic beads-ELISA-Tests etc. The world should use them to prepare for the pandemic outbreak. It has also multiplex tests for H7 and H9N2, which may also play a role. #Medicine #Virology #WHO #Retuers #AI

Our new study, in collaboration with researchers from Italy and Morocco, demonstrates the potent therapeutic potential of Crataegus monogyna. The hydroethanolic extract showed significant anti-inflammatory, hepatoprotective, and anticancer activities. It exhibited strong cytotoxicity against leukemia cells (K-562 and HL-60) and substantial hepatoprotective effects at higher doses. Molecular docking identified key active compounds, including procyanidin, quercetin, and catechin. These findings position C. monogyna as a promising candidate for treating liver damage, inflammation, and leukemia. Check out the full study for more details! https://lnkd.in/dCKPJ3HT

【The Combination Effect of Daphne Extract and Imatinib on the Antiproliferative Activity of the K562 Cell Line】 Full article: https://lnkd.in/gS7HSC_P (Authored by Alireza Khorshid, et al., from University of Texas Medical Branch at Galveston (USA), etc.)   Medicines made from natural materials and herbal extracts have been shown to reduce drug resistance and increase survival in patients. #Imatinib is a tyrosine kinase inhibitor that is used for targeted therapy for chronic myelogenous leukemia. This study focuses on the simultaneous effects of using herbal medicine and a target therapy medicine on the K562 cell line, investigates the intracellular mechanism of the cytotoxic effect of Daphne by examining the effect of #Daphne extract and in combination with imatinib, and evaluates the cytotoxic effects of Daphne extract on chronic myelogenous leukemia cells. #Apoptosis #Herbal_Medicine

Cytokines have critical roles in the pathogenesis of immunological and inflammatory diseases and can be targeted therapeutically. Janus kinase (JAK) proteins are essential signaling mediators that act downstream of pro-inflammatory cytokines. In recent years, JAK inhibition as a treatment strategy has gained widespread recognition in the field of autoimmune disease treatment. In our latest issue of OncoWuXi Express, WuXi Biology scientists evaluate the efficacy of different JAK subtype inhibitors in a type II collagen-induced arthritis model, along with corresponding in vivo models of rheumatoid arthritis. Click this link 👇 to read our article. https://lnkd.in/ggTeaP94 #Biotech #Biopharma #DrugDiscovery #Janus #JAK #Rheumatoid #Cytokines #Autoimmune

#RamalingaswamiFellow #DBT #NewResearch The Department of Biotechnology's #RamalingaswamiFellow Dr. Divya P. Kumar and her team at JSS Medical College, JSS AHER, identifies TNF-α converting enzyme (TACE) inhibition as a promising therapeutic intervention for #hepatocarcinogenesis induced by metabolic dysfunction-associated steatohepatitis #MASH #MASH-driven hepatocellular carcinoma (MASH-HCC) is a global clinical challenge with limited understanding of disease pathogenesis and a subsequent lack of therapeutic interventions. Metabolic dysfunction-associated steatotic liver disease #MASLD, formerly known as nonalcoholic fatty liver disease #NAFLD, has emerged as a leading cause of chronic liver disease worldwide, with metabolic dysfunction-associated steatohepatitis (MASH, formerly NASH) representing the more severe form. #MASH is gaining greater prominence on a global scale, and it is acknowledged as the leading contributor to HCC in both developed and developing nations. This progression from MASH to HCC occurs gradually, influenced by a myriad of factors, underscoring the critical importance of early intervention and continuous monitoring to manage the risk of HCC in individuals with #MASH. In this study, the team identified the SIRT1/TIMP3/TACE axis involved in the release of TNF-α, which upregulates AATF, a key molecular driver of MASH-HCC. This study shows that inhibition of TACE (TNF-α converting enzyme) by Marimastat reduces liver injury, dyslipidemia, AATF expression, and oncogenic signaling, effectively preventing hepatocarcinogenesis. This study provides proof of the principle that targeting TACE activity could offer potential solutions for the prevention of the AATF-mediated progression of steatohepatitis to hepatocarcinogenesis. Publication link: https://lnkd.in/g35zvBWT Rajesh Gokhale Department of Biotechnology

Our most recent paper, hot off the press! 🌟 Excited to share our latest research on understanding asthma susceptibility through genetics. We developed polygenic risk scores (PRSs) with strong predictive power for asthma risk, and linked genetic variants to specific biological pathways, offering potential for personalized treatment strategies. Read more about our findings through the link in Bernard's post below!

【The Combination Effect of Daphne Extract and Imatinib on the Antiproliferative Activity of the K562 Cell Line】 Full article: https://lnkd.in/gSPsfuBM (Authored by Alireza Khorshid, et al., from University of Texas Medical Branch at Galveston (USA), etc.) Medicines made from natural materials and herbal extracts have been shown to reduce drug resistance and increase survival in patients. #Imatinib is a tyrosine kinase inhibitor that is used for targeted therapy for chronic myelogenous leukemia. This study focuses on the simultaneous effects of using herbal medicine and a target therapy medicine on the K562 cell line, investigates the intracellular mechanism of the cytotoxic effect of Daphne by examining the effect of #Daphne extract and in combination with imatinib, and evaluates the cytotoxic effects of Daphne extract on chronic myelogenous leukemia cells. #Apoptosis #Herbal_Medicine Official submission link:https://lnkd.in/gf-cXBTN