Tomorrow our CEO Rabia T. K. will be at the RNA Medicine and Innovation in Montreal (RMedI) Symposium sharing insights about our work mapping the Druggable Transcriptome. You can register here https://lnkd.in/ejaJRuNh
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Blood Lipid Levels Linked to Rare Long, Non-Coding RNA Variants in TOPMed Cohort. With this whole-genome sequence data, researchers unearthed associations between blood lipid levels and dozens of rare variants in long non-coding RNAs. http://ow.ly/lAoM104WPcb
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Highly recommend this perspective on RNA structure, dynamics, and function as we all strive to enable #RNAx. https://lnkd.in/gEH5FEQ6
Thoughts on how to think (and talk) about RNA structure | Proceedings of the National Academy of Sciences
pnas.org
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PhD Candidate | Biochemistry | Structural biology | RNA structure and function | Virology | X-ray Crystallography
This paper is an excellent resource for learning how to discuss RNA effectively!
Highly recommend this perspective on RNA structure, dynamics, and function as we all strive to enable #RNAx. https://lnkd.in/gEH5FEQ6
Thoughts on how to think (and talk) about RNA structure | Proceedings of the National Academy of Sciences
pnas.org
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CIHR Postdoctoral Research Fellow studying myeloid cell communication, vascular inflammation, and hypercholesterolemia
Excellent! In my opinion, #myeloid #chemotaxis as a therapeutic target for early #atherosclerosis, still has so much potential. #inflammation is more than just cytokines, #monocyte recruitment is also “inflammation”! Let’s get those atherogenic monocytes!
Our new paper is out today in Cell Reports! My co-first authors, Jingshu Chen and Winona Wu, are two Wonder Women who made this labor of love possible! Along with our wonderful team, we describe a novel long non-coding RNA, which we named "MERRICAL", as a regulator of macrophage chemotaxis in the context of diabetes associated atherosclerosis. Congrats, team! 🥂. Brigham and Women's Hospital https://lnkd.in/d2CwQxpH
Deficiency of lncRNA MERRICAL abrogates macrophage chemotaxis and diabetes-associated atherosclerosis
cell.com
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Saliva is proving itself to be a readily available and abundant alternative to invasive blood draws and tissue biopsies as a source of nucleic acids. Indeed, saliva-based testing has become popular in recent years for both disease research and diagnostics. However, earlier saliva collection solutions were designed for either DNA or RNA applications. With researchers increasingly moving towards multi-omic approaches, there is a need for saliva collection that can collect and stabilize both DNA and RNA. Download this white paper from DNA Genotek Inc. to discover a new device that pairs the benefits of saliva collection with the performance needed for multi-omic research. Check out the white paper: https://lnkd.in/en-DahR4
Download this white paper from DNA Genotek Inc. to discover a new device that pairs the benefits of saliva collection with the performance needed for multi-omic research.
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I'm happy to share our latest NAR paper in the field of drug discovery against Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. We are presenting the first crystal structure of GGCCCC RNA in complex with the synthetic molecule ANP77. We determined that RNA folds into a triplex-like structure involving protonated cytosine residues, whereas ANP77 interacts directly with RNA via pseudo-canonical base pairs. These crystallographic models are rare examples demonstrating unexplored potential of cytosine-rich sequences to form complex RNA structures and provide sophisticated crystallographic templates for structure-guided approaches in the development of lead compounds for drug discovery against ALS/FTD.
Antisense RNA C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms a triplex-like structure and binds small synthetic ligand
academic.oup.com
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This stunning image – a collaboration between Ochre's RNA chemistry and Tissue Culture teams – is a thin slice of human liver... One of hundreds of slices we are able to culture from a small piece of diseased liver. Diseased tissue culture allows us to study the effects of our siRNA therapies before moving onto whole livers. Using fluorescent dyes, the teams can track where an siRNA therapy is being delivered to. In this case, mostly to hepatocytes (yellow). At Ochre we study over 20 different types of cells in the liver, using transdisciplinary methods like this to improve how we specifically deliver our therapies to them. #TeamOchre #healthtech #biotech #genomics #liverdisease
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📣 𝗘𝘅𝗰𝗶𝘁𝗶𝗻𝗴 𝗡𝗲𝘄𝘀: 𝗙𝗶𝗿𝘀𝘁 𝗠𝗢𝘅 𝟮.𝟬 𝗦𝗮𝗺𝗽𝗹𝗲 𝗣𝗿𝗼𝗰𝗲𝘀𝘀𝗲𝗱 𝗮𝘁 CENTOGENE! We are thrilled to share that last week we’ve received and sequenced our first MOx 2.0 sample – coming all the way from Panama on our sample collection solution CentoCard®! MOx 2.0 is at the forefront of our commitment to innovation in rare and neurodegenerative disease diagnostics. With advanced multiomic capabilities, now including RNA analysis, it empowers us to provide even more comprehensive insights and life-changing answers to patients and healthcare providers. Learn more about MOx 2.0 and its transformative capabilities in our upcoming webinar on November 15: https://lnkd.in/efK67Azr #MOx #Multiomics #Transcriptomics #Launch #MultiomicRevolution #PrecisionMedicine #RNA #Sequencing #Innovation #Diagnostics #RareDisease #CentoTalk #Webinar
Learn more about CENTOGENE's transcriptomic approach
centogene.com
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Exciting News: Our Inaugural Paper of 2024! Unraveling the intricate world of alternative splicing, a post-transcriptional process crucial for amplifying protein diversity. The orchestration of alternative splicing is wielded by RNA binding proteins, exhibiting various control mechanisms. However, amidst the myriad of predicted RNA binding proteins, a systematic evaluation of their direct involvement in enhancing exon inclusion remains unexplored. In our latest research study, we share our systematic assessment of hundreds of both established and predicted RNA binding proteins. The focus of our study revolves around discerning their potential to directly influence exon inclusion (by tethering). This undertaking marks a step forward in clarifying the network of proteins responsible for shaping the transcriptome. As an intriguing implication, we hint at the identification of promising candidates that could be seamlessly fused with RNA-targeting proteins. We find exon suppression is relatively trivial for RNA binding proteins (many modalities here) but this fusion holds the potential to cause exon inclusion over reporter and endogenous splicing events, offering a glimpse into the future possibilities of manipulating RNA processing with higher precision. Congrats newly minted alumni Jon Schmok and others from my lab! Thank you Marko Jovanovic and Lena Street for the collaboration. #RNA #RNAbindingproteins #splicing https://lnkd.in/gyDN4e-R
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Assessing levels of circulating free and EV-associated nucleic acids in the plasma of glioblastoma patients: in their latest work, Elisabeth Rackles, Juan Manuel Falcon Perez at CIC bioGUNE and collaborators reported a straightforward and reproducible method to analyse cell-free nucleic acids in plasma and EVs using conventional flow cytometry, which can be easily translated into clinical practice https://lnkd.in/e-P587k3 They demonstrated that Pyronin Y-fluorescent staining of EVs isolated from cell-conditioned media is an effective method for detecting DNA and RNA using flow cytometry. An article co-authored by Elena Zaccheroni, Patricia Hernández López, Stefania Faletti, Massimiliano Del Bene, Francesco DiMeco and Giuliana Pelicci #extracellularvesicles #exosomes #glioblastoma #RNA #flowcytometry #Vesiculab
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