Spontaneous Russell’s Post

Have you been meaning to find out more about #VisiumHD? This blog is for you, introducing you to the basics of the HD technology and workflow, why the CytAssist matters, FAQs about sample compatibility and data analysis, and biological examples of the discovery power of high-resolution #spatialtranscriptomics. Check it out!

If you have interest in spatial biology, take a look at this recent blogpost from 10X Genomics... about half way into the post, they show some beautiful images of mouse swiss-rolls and how the Visium HD can pinpoint specific expression of cell types, including Paneth cells...imagine what other gene signatures one could find to correlate with changes in epithelial cell composition in tissues! Alimentiv's specialty histopathology lab, AcelaBio, offers 10X Genomics Visium workflows, including the Visium HD! Let me know if you're interested and we can talk about your ideas for exploring spatial biology!

Trouble managing flow cytometry data? TetraScience has created a more efficient, collaborative approach to data management by advancing cloud-based flow cytometry analysis. With the Tetra Data and AI Workspace, prominent analysis software can now be conveniently co-located with scientific data for streamlined workflows and reduced time-to-insight. Learn how scientists are revolutionizing their flow cytometry analysis with this innovative platform: https://lnkd.in/e9G74yMw #FlowCytometry #ScientificAI #ScientificData

https://lnkd.in/gAhaxYRy Accelerating and simplifying the insight is where the GenAI and using focused Granite LLMs really makes a difference. This is where medical science can provide early detection to improve an outcome. I urge all to have a read and remind ourselves that no one is immune without regular self care. Wishing CanSense much success and the work which they do today to be available across the globe in years to come.

For years, the focus on sequencing tech has been on cost (which has been achieved with running many samples in parallel). But maybe the focus should have actually been on speed. It's not that cost doesn't matter but what makes sequence data useful is getting the appropriate insight in time for a decision. Once you're in the $100s-$1000s price range, at least in a clinical setting, it's more about being able to act on the information than shaving another few dollars off the price tag.

Exciting breakthrough in single-cell genomics! 🧬 scGHOST, a cutting-edge method for annotating single-cell subcompartments in 3D genome organization. This innovative approach sheds light on the intricate variability of nuclear architecture within individual cells. What's particularly intriguing is its potential impact on transcriptional regulation and our understanding of brain development. By identifying cell-type-specific subcompartments linked to gene transcription, scGHOST offers invaluable insights into how gene expression is finely tuned during neurodevelopment. This opens up new avenues for unraveling the complexities of brain function and disease. A remarkable advancement indeed! 🌟 #SingleCellGenomics #TranscriptionalRegulation #BrainDevelopment #ResearchInnovation

Journey into the future of #drugdiscovery with advances in #highcontentscreening. Explore 3D cell models, multiplexing, and data management tools revolutionizing research. http://ms.spr.ly/6041YWpbL #HCS

Journey into the future of #drugdiscovery with advances in #highcontentscreening. Explore 3D cell models, multiplexing, and data management tools revolutionizing research. http://ms.spr.ly/6044YWpdC #HCS

Most interesting interview with Susan Tousi, CEO of DELFI Diagnostics, on #DNA #Fragmentomics as early #biomarker for #cancer. Cancers cells have unstable genomes and high turnover. When they die their DNA is released into blood and can be detected in #liquid #biopsy samples. #AI models are trained to sensitively detect cancer fragments in whole #genome #sequencing data for early cancer #detection. Ourselves have embarked on a similar project based on #RNA in collaboration with RealSeq Biosciences. RNA Fragmentomics has also a #multiomics dimension by providing information about many different RNA species, as well as information about #isoforms, alternative #splicing and other variants that reflect #disease, while also providing sequence variance information in the #exome. Stay in touch - Fragmentomics is hear! https://lnkd.in/dGZANuRG Illumina Natera Roche Sequenom GRAIL Myriad Genetics Thermo Fisher Scientific QIAGEN Bio-Rad Laboratories Biocartis Sysmex Corporation Agilent Technologies mdxhealth Guardant Health NeoGenomics Laboratories LUCENSE Simsen Diagnostics Personal Genomics SAGA Diagnostics Agena Bioscience MENARINI Group Mirxes Biocept, Inc. CellMax Life Inivata Freenome Exosome Diagnostics Biodesix, Inc. Guardant Health ANGLE BioVendor Group Stilla Technologies

Machine learning enables pan-cancer identification of mutational hotspots at persistent CTCF binding sites https://lnkd.in/e_7qn-ky