A family of solute carriers (SLC) is an important group of membrane transporters involved in drug absorption, distribution and elimination. Regulatory authorities (EMA, FDA) recommend investigating the potential roles of SLC superfamily members OATP1B1, OATP1B3, OAT1, OAT3, OCT2, MATE1 and MATE2 for transporter-mediated drug-drug interactions (DDI), by evaluating whether the new drug candidate is a substrate (potential DDI victim) or an inhibitor (potential DDI perpetrator) towards drug transporters. In addition, EMA suggests also considering investigation of OCT1, whenever in vitro and in vivo findings suggest its involvement in DDI to be anticipated. Learn more via this post and the Admescope website. #Symeres #Admescope #Transporters #DrugDiscovery #DrugDevelopment
A family of solute carriers (SLC) is an important group of membrane transporters involved in drug absorption, distribution and elimination. Evaluation of transporter-mediated drug-drug interactions (DDI) is required by regulatory bodies to identify if a new drug candidate is an object (a substrate of an enzyme or a transporter, previously referred to as a ‘victim’) or a precipitant (a drug that can induce or inhibit an enzyme or transporter, previously referred to as a perpetrator). If you’d like to learn more about Uptake transporter Inhibition or Substrate studies, please contact us. https://lnkd.in/d5j27hXt Admescope a Symeres company #Admescope #Symeres #drugdevelopment #solutecarriers #membranetransporters #drugdruginteraction #uptaketransporters #
