Synnovation Therapeutics’ Post

ARJUNA Therapeutics develops highly targeted molecules for innovative cancer treatments, and after spending four years developing a GMP manufacturing process, is now ready for scale-up and clinical trials. The lead asset, #Ag5, represents a novel form of metal - five silver atoms are covalently bonded together using quantum chemistry to make a very small molecule capable of crossing the blood-brain barrier. #Ag5 is active in cells with high levels of mitochondrial activity and it catalyzes the reactive oxygen species in the mitochondria of cells. It holds promise as single agents and combinatorial therapies for solid tumors and as adjunct therapies to radiation to improve efficacy and limit side effects. Learn more here 👉 https://lnkd.in/eefKPutT. #cancer #radiationtherapy #molecules #quantumchemistry #inorganic #catalyst #pharma #biotech #drugcandidate #innovative #asset #clinicaltiral #Bioneex #BioneexStories

📢Check out the #Review "Cell-Penetrating Peptides (CPPs) as Therapeutic and Diagnostic Agents for Cancer" 🧐by Ryan A. Bottens and Tohru Yamada University of Illinois Chicago Find the full paper here👉 https://lnkd.in/dPKu4P7H Keywords: cell penetration; protein transduction; targeted delivery; therapeutics; diagnostics; clinical trial

🔬 Don't miss this Most-Cited Highlight! 📚 "Relevance of ABC Transporters in Drug Development" 🧪 Learn about: 1️⃣ Critical role of ABC Transporters in protecting vital organs 2️⃣ Structure and function of P-glycoprotein, Multidrug Resistance-Associated Protein 2, and Breast Cancer Resistance Protein 3️⃣ Techniques to evaluate drug-ABC transporter interactions Discover more: https://bit.ly/452flFl #DrugDevelopment #ABCTransporters #ResearchHighlight #Pharmacology #Science #BenthamScience

#siRNAs, a subclass of #oligonucleotides, can selectively silence disease-causing genes, offering new therapeutic opportunities. #GalNAc-siRNA conjugates have emerged as a key strategy in cancer therapy due to their targeting capabilities. Read this WuXi TIDES case study to see how our integrated CMC services managed oligonucleotide synthesis, GalNAc supply, formulation development, manufacturing, and analytical support. Using innovative conjugation chemistry and tailored analytical studies, we significantly improved crude purity and yield, delivering two siRNA-GalNAc CMC packages ready for IND submission within 14 months. Visit our website: https://lnkd.in/g6AmChYd #WuXiTIDES #siRNAs #oligonucleotides #therapies

New treatments that are effective against resistant mutant AML is of high unmet need. Download this publication to learn how Crown Bioscience collaborated with Hanx Biopharmaceuticals and other cancer researchers for this study, investigating the efficacy of narazaciclib, a novel multi-kinase inhibitor, and how it targets and inhibits key kinases involved in AML models. You can also learn more about which Crown Bioscience AML preclinical models were used. #OncologyResearch #DrugDevelopment #AcuteMyeloidLeukemia

New treatments that are effective against resistant mutant AML is of high unmet need. Download this publication to learn how Crown Bioscience collaborated with Hanx Biopharmaceuticals and other cancer researchers for this study, investigating the efficacy of narazaciclib, a novel multi-kinase inhibitor, and how it targets and inhibits key kinases involved in AML models. You can also learn more about which Crown Bioscience AML preclinical models were used. #OncologyResearch #DrugDevelopment #AcuteMyeloidLeukemia

In this lecture, Intellia Therapeutics, Inc. will provide an overview of how Intellia is leveraging its CRISPR-based technologies to develop novel, potentially curative therapeutics. To fully realize the transformative potential of CRISPR-based technologies, Intellia is pursuing two primary approaches. https://bit.ly/3P0hSJG The company’s in vivo investigational programs use intravenously administered CRISPR as the therapy, in which proprietary delivery technology enables highly precise editing of disease-causing genes directly within specific target tissues. Intellia’s investigational ex vivo programs use CRISPR to create the therapy by using engineered human cells to treat cancer and autoimmune diseases. #CRISPR #GenomeEditing #genomesequencing

Happy Halloween! No tricks here, just the magic of science 😉 #Insilico modelling of human trials is a powerful tool to predict outcomes in oncology drug development…. but it’s important to tread carefully when interpreting the results. 💡 The magic ingredient? Start with an established model of treatment and tumour characteristics. ✨ Our Virtual Tumour™ platform is one of the industry’s most advanced predictive models focused solely on oncology. Our model is calibrated using available PK and PD data and can predict the effect on tumour growth of combinations of anti-cancer agents, including radiation. 🔬 Eager to learn how we can help you brew up success in drug development? 👀 Let's chat! #Cancer #DrugDevelopment #Insilico #VirtualTumour #TranslationalModelling #CancerDrugs #CancerSimulation #CombinationTherapies #BioTech #Pharma #PYC

We're thrilled to announce the publication of groundbreaking research on narazaciclib and its anti-AML activity in preclinical models with specific AML mutations of clinical significance. This collaboration between Hanx Biopharmaceuticals, Crown Bioscience, and other cancer researchers has revealed promising results in targeting and inhibiting key kinases involved in AML. Dive deeper into our findings and discover how our collaborative efforts are contributing to treatments for AML. ➡️ https://bit.ly/3UrLjH7 #OncologyResearch #DrugDevelopment #AcuteMyeloidLeukemia

Now available from 2BScientific Ltd. learn more about where Echelon’s PI4K Kinase related kits fit into your workflow, take a look at our full article here: https://lnkd.in/exQfwnfp Echelon Biosciences recognises the significance of investigating the involvement of PI4K in cellular signalling, as evidenced by the notable reagents they offer. 🐝 PI(4)P Mass ELISA Kit - Precisely quantifies PI(4)P with unmatched specificity. 🐝 PI4-Kinase Activity Assay - Essential for understanding membrane signaling by measuring PI(4)P levels. 🐝 Purified Anti-PtdIns(4)P Monoclonal Antibody - Highly specific for targeting PtdIns(4)P, aiding research on cell signaling. Our friendly team at 2BScientific Ltd. guarantees fast service and 100% product satisfaction, make sure to get in contact at sales@2bscientific.com with any queries about Echelons products, or anything concerning life science reagents! #oncology #proteomics #lipids #cancerresearch #cellbiology