In a new study, researchers at Weill Cornell Medicine, including CRI Lloyd J. Old STAR Dr. Gregory Sonnenberg, identified a previously unknown link between two key pathways that regulate the immune system in mammals. "Until now, most research on CTLA-4 focused on T cells, another type of immune cell. By uncovering that it is selectively upregulated on ILC3s by IL-23, this demonstrates that we should be thinking about these pathways more broadly to develop more selective therapeutics," describes Dr. Sonnenberg. Discover: https://bit.ly/4b7Msdp #Immunotherapy #CancerResearch #IBD #TCells
Cancer Research Institute (CRI)’s Post
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Assistant Editor of Exploration of Immunology（EI, a free of charge and open access online journal. Now EI is indexed in Scopus, DOAJ, etc.）
📢 Newly Published Paper Sharing: Entrance to the multifaceted world of CD4+ T cell subsets #tcells #lymphocyte 👥 Authors: Murilo Porfírio de Aguiar, Julia Hailer Vieira 🔑 Keywords: Helper lymphocyte, regulatory lymphocyte, T helper cell, regulatory T cell, #CD4+, subsets 🎯 "...The research underscores the clinical relevance of CD4+ T cell subset dysregulation in various diseases, advocating for a nuanced understanding of these subsets for potential therapeutic advancements in immune-related disorders." 🔗 Read the full article: https://lnkd.in/gXPxuMww
Entrance to the multifaceted world of CD4+ T cell subsets
explorationpub.com
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📢 Newly Published Paper Sharing: Entrance to the multifaceted world of CD4+ T cell subsets #tcells #lymphocyte 👥 Authors: Murilo Porfírio de Aguiar, Julia Hailer Vieira 🔑 Keywords: Helper lymphocyte, regulatory lymphocyte, T helper cell, regulatory T cell, #CD4+, subsets 🎯 "...The research underscores the clinical relevance of CD4+ T cell subset dysregulation in various diseases, advocating for a nuanced understanding of these subsets for potential therapeutic advancements in immune-related disorders." 🔗 Read the full article: https://lnkd.in/gYbTgQvh
Entrance to the multifaceted world of CD4+ T cell subsets
explorationpub.com
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Assistant Editor of Exploration of Immunology（EI, a free of charge and open access online journal. Now EI is indexed in Scopus, DOAJ, etc.）
📢 Daily Paper Sharing: Entrance to the multifaceted world of CD4+ T cell subsets #tcells #lymphocyte 👥 Authors: Murilo Porfírio de Aguiar, Julia Hailer Vieira 🔑 Keywords: Helper lymphocyte, regulatory lymphocyte, T helper cell, regulatory T cell, #CD4+, subsets 🎯 "...The research underscores the clinical relevance of CD4+ T cell subset dysregulation in various diseases, advocating for a nuanced understanding of these subsets for potential therapeutic advancements in immune-related disorders." 🔗 Read the full article: https://lnkd.in/gXPxuMww
Entrance to the multifaceted world of CD4+ T cell subsets
explorationpub.com
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A recent clinical trial has shown promising results, with three autoimmune disease patients responding positively to an allogeneic CD19-directed CAR-T therapy. Read more: https://lnkd.in/erWcyBB5 This is the first clinical proof-of-concept demonstrating the efficacy and safety of an “off the shelf” cell therapy for autoimmune disease, marking a significant milestone for the field! Learn how Discovery's expertise in donor recruitment and management can propel advancements in allogeneic cell therapy development for cancers, autoimmune diseases, and more: https://lnkd.in/gHyaMqQA #CARTCellTherapy #AutoimmuneDiseases #Allogeneic
In a first, patients with autoimmune diseases respond to allogeneic CAR-T treatment
fiercebiotech.com
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CSO and Board Member at JJP Biologics│BD & Serial entrepreneur │ Founder & Speaker│Academic collaborator │ ”Passion is unstoppable”
Evidence is accumulating……
IgA autoantibodies in Alzheimer Disease✨✨ While microglia, the resident immune cells of the central nervous system, play a crucial role in AD, recent evidence suggests the infiltration of cerebral vessels and parenchyma by peripheral immune cells, including neutrophils, T lymphocytes, B lymphocytes, NK cells, and monocytes in AD. Obviously, if peripheral immune cells can use the breaches in the BBB, IgA autoantibodies are also able to penetrate to the lesions. More evidence of the involvement of neutrophils are source of MPO activity is the subject of current JJP Biologics scientific post. Because due to breaches in the BBB, next to CD89 expressing and resident microglia, CD89-expressing peripheral neutrophils and monocytes get access to the CNS. The current manuscript shows data in the human AD brain suggesting that neutrophils accumulate, and are associated with blood vessels in AD where they may contribute to vascular stalling and BBB leakage. It was also shown that neutrophils and NETs are the key source of MPO in the brain during AD which may represent an important mechanism through which BBB inflammation influences oxidative stress in AD. https://lnkd.in/g92AWPUV Since IgA autoantibody deposits are found in AD brain, and the observation that these are of the IgA isotype is not coincidental. These IgA autoantibodies could, when the bind their target in brain, provide an IgA matrix to myeloid cells like neutrophils, monocytes and also resident microglia through cross-linking of the the CD89 receptor resulting in activation of MPO and consequently resulting in severe tissue damage. The oxidative force of MPO is one of the causes of the tissue damage. For this reason, JJP Biologics has developed JJP-1212, which completely blocks the potent effector functions like MPO activation of these IgA auto-antibodies. Stay tuned with JJP Biologics and follow us here on LinkedIn. Be a smart goose 🎆🎆 https://lnkd.in/eZV3ZbS9 #JJP1212 #AntiCD89 #IgA #AgencjaBadańMedycznych #SMARTGOOSE
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Assistant Editor of Exploration of Immunology（EI, a free of charge and open access online journal. Now EI is indexed in Scopus, DOAJ, etc.）
📢 Daily Paper Sharing: Entrance to the multifaceted world of CD4+ T cell subsets #tcells #lymphocyte 👥 Authors: Murilo Porfírio de Aguiar, Julia Hailer Vieira 🔑 Keywords: Helper lymphocyte, regulatory lymphocyte, T helper cell, regulatory T cell, #CD4+, subsets 🎯 "...The research underscores the clinical relevance of CD4+ T cell subset dysregulation in various diseases, advocating for a nuanced understanding of these subsets for potential therapeutic advancements in immune-related disorders." 🔗 Read the full article: https://lnkd.in/gXPxuMww
Entrance to the multifaceted world of CD4+ T cell subsets
explorationpub.com
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Assistant Editor of Exploration of Immunology（EI, a free of charge and open access online journal. Now EI is indexed in Scopus, DOAJ, etc.）
📢 Daily Paper Sharing: Entrance to the multifaceted world of CD4+ T cell subsets #tcells #lymphocyte 👥 Authors: Murilo Porfírio de Aguiar, Julia Hailer Vieira 🔑 Keywords: Helper lymphocyte, regulatory lymphocyte, T helper cell, regulatory T cell, #CD4+, subsets #Tcell 🎯 "...The research underscores the clinical relevance of CD4+ T cell subset dysregulation in various diseases, advocating for a nuanced understanding of these subsets for potential therapeutic advancements in immune-related disorders." 👤 Academic editor: Dominique J. Charron, Hospital Saint Louis, France 🔗 Read the full article: https://lnkd.in/gXPxuMww
Entrance to the multifaceted world of CD4+ T cell subsets
explorationpub.com
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📢 Daily Paper Sharing: Entrance to the multifaceted world of CD4+ T cell subsets #tcells #lymphocyte 👥 Authors: Murilo Porfírio de Aguiar, Julia Hailer Vieira 🔑 Keywords: Helper lymphocyte, regulatory lymphocyte, T helper cell, regulatory T cell, #CD4+, subsets 🎯 "...The research underscores the clinical relevance of CD4+ T cell subset dysregulation in various diseases, advocating for a nuanced understanding of these subsets for potential therapeutic advancements in immune-related disorders." 🔗 Read the full article: https://lnkd.in/gYbTgQvh
Entrance to the multifaceted world of CD4+ T cell subsets
explorationpub.com
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📢 Daily Paper Sharing: Entrance to the multifaceted world of CD4+ T cell subsets #tcells #lymphocyte 👥 Authors: Murilo Porfírio de Aguiar, Julia Hailer Vieira 🔑 Keywords: Helper lymphocyte, regulatory lymphocyte, T helper cell, regulatory T cell, #CD4+, subsets 🎯 "...The research underscores the clinical relevance of CD4+ T cell subset dysregulation in various diseases, advocating for a nuanced understanding of these subsets for potential therapeutic advancements in immune-related disorders." 🔗 Read the full article: https://lnkd.in/gYbTgQvh
Entrance to the multifaceted world of CD4+ T cell subsets
explorationpub.com
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🔬 Myeloid Cells: A Frontier in Therapeutic Interventions 🔬 Myeloid cells, key players in the immune system, are at the forefront of innovation in therapeutic research. From monocytes and macrophages to granulocytes, dendritic cells, and mast cells, these versatile immune cells adapt and respond rapidly to various stimuli. Their ability to combat infections, regulate inflammation, and maintain homeostasis makes them prime targets for developing novel therapies across oncology, autoimmunity, and inflammatory diseases. At Biocytogen, we’re harnessing the power of myeloid cells through our advanced RenMice® antibody discovery platform. Our myeloid cell-related antibody assets offer exciting opportunities for drug development, paving the way for breakthroughs in multiple disease areas. Get in touch with us today to explore how our innovative solutions can help advance your research! #MyeloidCells #Immunotherapy #Oncology #Autoimmunity #Inflammation #Biotech #AntibodyDiscovery #Biocytogen #RenMice
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