Antimicrobial resistance (AMR) is one of the most critical public health challenges of our time. In 2021, an estimated 4.71 million deaths were associated with bacterial AMR. Multidrug-resistant Gram-negative bacteria are responsible for much of this threat. In response, several new diagnostic technologies aimed at rapidly detecting AMR have been developed. The last decade has also seen the licensing of antibiotics that have changed the treatment landscape for these challenging infections. Find out more 👉 hubs.li/Q033jgKr0 Figure: Mechanisms of action of key antibiotics for the treatment of multidrug-resistant Gram-negative bacterial infections #AMR #PublicHealth #MedicalResearch #TheLancet
Very interesting topic 👏
Antimicrobial resistance is one of the most critical challenges we face, and I’m genuinely excited about the development of new diagnostics and therapeutics with innovative mechanisms of action. That said, as a physician, the first thing that comes to mind when discussing AMR is the improper use of antibiotics, which remains a major driver of resistance. Educating prescribers and reinforcing the importance of adhering to guidelines are just as crucial as advancing new treatments. Combining cutting-edge innovation with responsible prescribing practices will be key to tackling this issue effectively. Excited to see how these efforts evolve!
As a clinician, we are the ones who make the maximum negative contribution to antibiotic resistance. In daily practice, despite all the literature written, our preference is often empirical antibiotic therapy based on physical examination and laboratory findings and to avoid legal consequences. This is a fact that everyone knows but no one feels uncomfortable with. Still, a nice article published in Lancet.
"Antimicrobial resistance (AMR) is indeed a critical public health challenge globally, and Pakistan is no exception. With the misuse of antibiotics being rampant, limited regulations, and poor public awareness, AMR is escalating rapidly in the country. Interventions in Pakistan must focus on strict prescription monitoring, improving diagnostic facilities, and creating widespread awareness about the consequences of antibiotic misuse. Additionally, promoting antimicrobial stewardship programs in hospitals and enhancing surveillance systems are vital steps to combat this growing threat effectively."
Congratulations! Multidrug-resistant Gram-negative bacterial infections and AMR are a rapidly growing concern in urology, since the identified priority pathogens are all highly related to urinary tract infections! Raising awareness in the urologic community and performing research on urinary tract infections has never been more important.
Thank you for sharing this informative post on the critical issue of antimicrobial resistance. It's encouraging to see the development of new diagnostic technologies and the licensing of antibiotics that can help combat multidrug-resistant Gram-negative bacteria. However, it's important to note that addressing AMR requires a multifaceted approach that includes not only the development of new treatments but also efforts to promote responsible use of antibiotics, improve infection prevention and control measures, and invest in research and development. We must work together to tackle this global health challenge and ensure the continued effectiveness of antibiotics for future generations.
Very informative
AMR is becoming a silent pandemic.
Professor of Bioinorganic Chemistry at University of Sheffield
2moA useful précis of the challenges for researchers