The New Optometrist’s Post

Could a neuropeptide with cytoprotective and pro-regenerative properties offer #ophthalmologists a viable alternative to #corneal transplants? 📰Read the full article here: https://bit.ly/42wSYru #optometry #eyecare

Could a neuropeptide with cytoprotective and pro-regenerative properties offer #ophthalmologists a viable alternative to #corneal transplants? 📰Read the full article here: https://bit.ly/42wSYru #optometry #eyecare

#spinalcordinjury #Ferroptosis #vascularendothelialcell #bloodspinalcordbarrier #recovery Ferroptosis inhibition protects vascular endothelial cells and maintains integrity of the blood-spinal cord barrier after spinal cord injury https://lnkd.in/gnKwqj4A Maintaining the integrity of the blood-spinal cord barrier is critical for the recovery of spinal cord injury. Ferroptosis contributes to the pathogenesis of spinal cord injury. We hypothesized that ferroptosis is involved in disruption of the blood-spinal cord barrier. In this study, we administered the ferroptosis inhibitor liproxstatin-1 intraperitoneally after contusive spinal cord injury in rats. Liproxstatin-1 improved locomotor recovery and somatosensory evoked potential electrophysiological performance after spinal cord injury. Liproxstatin-1 maintained blood-spinal cord barrier integrity by upregulation of the expression of tight junction protein. Liproxstatin-1 inhibited ferroptosis of endothelial cell after spinal cord injury, as shown by the immunofluorescence of an endothelial cell marker (rat endothelium cell antigen-1, RECA-1) and ferroptosis markers Acyl-CoA synthetase long-chain family member 4 and 15-lipoxygenase. Liproxstatin-1 reduced brain endothelial cell ferroptosis in vitro by upregulating glutathione peroxidase 4 and downregulating Acyl-CoA synthetase long-chain family member 4 and 15-lipoxygenase. Furthermore, inflammatory cell recruitment and astrogliosis were mitigated after liproxstatin-1 treatment. In summary, liproxstatin-1 improved spinal cord injury recovery by inhibiting ferroptosis in endothelial cells and maintaining blood-spinal cord barrier integrity.

Ophthopedia Update:Disparities in Retinal Vein Occlusion Presentation and Initiation of Anti-VEGF Therapy: an Academy IRIS® Registry Analysis: Investigate disparities in retinal vein occlusion (RVO) presentation and initiation of anti-vascular endothelial growth factor (anti-VEGF) treatment. #Ophthalmology #Retina #Ophthotwitter

How many times did you complain about your back pain in 2024? I recently discovered that the main cause of chronic low-back pain is the deterioration of the jelly-like discs between the vertebras. The worst part is that we don't know how to prevent or treat it. A group of scientists is investigating how neurons in this area modulate the process of intervertebral degeneration besides just signaling pain. In previous studies they defined the role of two neuropeptides released by sensory neurons: 🔴 CGRP --> stimulates inflammation and degradation of the extracellular matrix 🔵 Neuropeptide Y --> prevents cell apoptosis and extracellular matrix degradation Now, in a recent study, they uncovered the role of vasoactive intestinal peptide (or VIP) released by sympathetic neurons. ⚪ VIP --> decreased the deterioration of the intervertebral discs in a mouse model and even reverted the condition! Interested in more details? Check out the news article I wrote for Advanced Science News (and the paper links in the comments) https://lnkd.in/dkF_9uVu

Ferroptosis is a novel form of programmed cell death, distinguished from apoptosis, autophagy, and programmed necrosis and has received much attention since it was defined in 2012. Ferroptotic cells physiologically exhibit iron metabolism dysregulation, oxidative stress, and lipid peroxidation. Morphologically, they show plasma membrane disruption, cytoplasmic swelling, and mitochondrial condensation. Osteoporosis is taken more and more seriously as the proportion of the aging population continues to increase globally. Interestingly, ferroptosis has been demonstrated to be involved in the development and progression of osteoporosis in many extant studies. The review summarizes iron metabolism, lipid peroxidation, and the different regulatory signals in ferroptosis. Changes in signaling mechanisms within osteoblasts, osteoclasts, and osteocytes after ferroptosis occur are explained here. Studies showed ferroptosis play an important role in different osteoporosis models (diabetes osteoporosis, postmenopausal osteoporosis, glucocorticoid-induced osteoporosis). Inhibitors and EC (Exos) targeting ferroptosis could ameliorate bone loss in osteoporotic mice by protecting cells against lipid peroxidation. Shortly, we hope that more effective and appropriate clinical therapy means will be utilized in the treatment of osteoporosis. Read more on 📄 An update on the role of ferroptosis in the pathogenesis of osteoporosis https://bit.ly/3AJqz7O ✒️ Xinhui Wu, Xiaoxin Fang, Feng Lu, Qiong Chen, Junjian Liu, and Longpo Zheng #ferroptosis #osteoporosis #lipidperoxidation #oxidativestress #plasmamembrane #osteoblast #osteoclast #osteocytes #OpenReviews #orthopedics #orthopaedics #surgery #openaccess

Ophthopedia Update:Neurotrophic keratopathy: General features and new therapies.: Neurotrophic keratopathy is an uncommon degenerative corneal disorder characterized by compromised corneal sensory innervation, resulting in the formation of epithelial defects and nonhealing corneal ulcers. Various treatment modalities are available to stabilize disease progression, improve patient well-being, and prevent vision loss. For eligible patients, medical and surgical reinnervation have emerged as pioneering therapies, holding promise for better management. This article presents a comprehensive review of the disease, providing an update relevant to ophthalmologists on pathogenesis, diagnosis, treatment options, and novel therapies targeting pathophysiological pathways. #Ophthalmology #Eye #Ophthotwitter

There's concern over whether diagnostic discography can increase the risk of long-term lower back issues in patients. A 10-year cohort study from 2016 revealed that medical visits, CT scans, and MRI exams, loss of work, and extended episodes of back pain were more common in the discography group compared to control subjects. 🧐📊 https://lnkd.in/ebDHJRC5 It's traditionally believed that the damage from discography (if any) is purely physical, but there's evidence suggesting that iodinated contrast media can impact disc cells. 🚫 Cell culture studies have shown cytotoxic effects such as swelling and vacuolation of the mitochondria even at lower concentrations of Iodinated contrast than those used clinically. (❕) https://lnkd.in/eDaCKKy3 This cytotoxicity is even more alarming in the disc, as it's unclear how long the contrast can remain there. ⌛ Another study suggests that iodinated contrast and/or lidocaine may interfere with the biological repair mechanisms of the intervertebral disc, potentially contributing to further disc degeneration. 🚨 https://lnkd.in/e44nse5B Moreover, iodinated contrast can interfere with PRP regenerative mechanisms. This study found that radiographic contrast media can alter platelet behavior, inhibiting ADP-induced platelet aggregation. https://lnkd.in/e7YVFvCs 🔬 It's also been observed that some iodinated contrast media interfere with platelet activation and clot formation, affecting fibrinogen structure and platelet aggregation. 🤔 https://lnkd.in/ebDHJRC5 What can we do? ➡️Try to use the minimal amount of disc-level contrast. 🤏 ➡️Ozone might be an alternative for discography, or at least to check if the disc is competent. 🧿 ➡️Use contrast diluted to 50%, with 5% dextrose (D5W). 💧 ➡️After applying contrast, if the disc is not watertight (competent) use PPP to "wash out" the contrast, then apply PRP. 💦➡️🩸 Please share this post to spread awareness about the potential disc damage caused by contrast media. And don't miss the next Sociedad Española del Dolor congress for more updates on this topic. 📢👀 Thanks to the UCA - Doctor Mikel Sánchez team for supporting research in this area. #RegenerativeMedicine #PainTreatment #painmanagement #MedicalInnovation #regenerativemedicine #painmanagement #MedicalInnovation

Is organ transplantation illegal? It might sound surprising, but at one point in history, the concept of organ transplantation seemed like a distant dream—and it raised many ethical questions. But in 1954, medical history was changed forever with the first successful organ transplant. The surgery, a kidney transplant, was performed by Dr. Joseph Murray at Brigham Hospital in Boston. What made this surgery even more remarkable was that the donor and recipient were identical twins. Richard Herrick was suffering from kidney failure, and his twin brother, Ronald, stepped in to save his life. At the time, there were huge concerns about organ rejection. But because they were identical twins, the doctors knew Richard’s body would likely accept Ronald’s kidney without complications. It was a bold, pioneering move. No one had ever successfully transplanted an organ before, and many believed it was impossible or even unethical. But on December 23, 1954, everything changed. The surgery was a success, and Richard’s body accepted his brother’s kidney. This operation wasn’t just a victory for Richard—it was a breakthrough for the entire field of medicine. From that moment on, the possibilities seemed endless. Today, organ transplants have become life-saving procedures performed all over the world. But it all started with that first operation—one bold step into the unknown that sparked a revolution in healthcare. That first organ transplantation showed that not only is it legal but also a medical necessity that saves countless lives. The buying and selling of human organs is illegal. Everyone who involves in organ transplantation must follow the govt guidelines of that respective country. P.S: I welcome your thoughts in the comments section👇 #OrganTransplantation #OrganTransplantationHistory #MedicalBreakthrough #PioneersInMedicine #LifeSavingSurgery #MedicalInnovation #MedicalMarketing #HospitalSuccess images source: Google

In a groundbreaking development, eGenesis, Inc. and Mass General Brigham have successfully conducted the first xenotransplantation using a CRISPR gene-edited pig kidney. While this is very early in development, we hope that it can potentially open up new avenues in medical science to help address the critical shortage of human organs for transplantation. #xenotransplantation #CRISPR #medicalinnovation