Thera Research Ltda. CRO’s Post

Exciting Research Update! We're thrilled to share a recent publication that utilized our Calprotectin ELISA Assay Kit to explore the predictive power of patient-derived materials for clinical responsiveness to tofacitinib, a Janus kinase (JAK) inhibitor, in treating ulcerative colitis (UC). Key Takeaways: 🔹Patient-derived intestinal organoids were used to predict individual clinical responsiveness to tofacitinib prior to treatment. 🔹Sensitivity of organoids to tofacitinib correlated with drug responsiveness in patients, linked to the inhibition of STAT1 phosphorylation and cell viability upon cytokine stimulation. 🔹Decreased levels of the cationic transporter MATE1, responsible for tofacitinib uptake, were associated with reduced drug responsiveness. 🔹The study provides a potential method for predicting patient response to tofacitinib, which could lead to more personalized and effective treatment strategies for UC. #research #calprotectin #eaglebio https://buff.ly/4bphq1A

#mTOR inhibitors suppress the mammalian target of rapamycin (mTOR) pathway, which regulates autophagy and cell growth. By inhibiting mTOR, these drugs can modulate autophagy and have potential applications in cancer therapy, neurodegenerative diseases, and metabolic disorders. https://lnkd.in/gpqXvzzY #mTOR #inhibitors #autophagy #cellgrowth #cancertherapy #neurodegenerativediseases #metabolicdisorders #oncology #drugdevelopment #biology #research #cellularpathways #mTORpathway #targetedtherapy #scientificdiscoveries #biomedicalresearch #pharmacology #precisionmedicine #cellsignaling #healthcareinnovation #potentialapplications #diseaseprevention #bioscience #drugdiscovery #healthtech #medicalbreakthroughs #innovativetreatmentapproaches

Today, we are sharing our CEOs thoughts on a recent exciting industry development

Biological intelligence approach to Alzheimer's disease reveals that: 1. 76 of 1,208 (6.3%) of BRAINCURES Discovery Engine (BDE) Compounds are associated with long-term potentiation (LTP) and have a clinical Alzheimer's disease (AD) association. One such BDE compound is memantine, a drug that received a US FDA approval for treatment of AD in 2003; 2. 229 of 1,208 (18.9%) BDE-compounds have a clinical Alzheimer's disease association. 153 of the above 229 (66.8%) BDE-compounds do not have a published LTP-AD association yet; 3. 623 of 1,208 (51.6%) of BDE-Compounds are associated with long-term potentiation and have a preclinical Alzheimer's disease association

Can #ketamine and its metabolites, such as HNK, be used beyond depression as therapeutics? We explored that in a now published manuscript, demonstrating that HNK can reverse synaptic and behavioural deficits in mouse models of #Alzheimers… check it out! https://lnkd.in/eEm9cHAx

INDUSTRY NEWS - CAR-T in autoimmunity My thoughts on the news 'Cartesian Therapeutics clears an autoimmune CAR-T trial, starts another Phase 2 and raises $130M' https://lnkd.in/eHtpW7T3 This is an exciting development that expands on tantalizing CAR-T data in autoimmunity first reported in lupus last year. Is autoimmunity the saving grace for the CAR-T field as multiple companies migrate from oncology? The competition will be no less fierce in autoimmunity where mAbs have made significant advances over the years and are truly off-the-shelf products, and cheaper as well. One key question concerns how many CAR-T products can the autoimmunity field accommodate, especially if they are all targeting B cell specific antigens. Perhaps the competitive landscape will be adjudicated by the relative durability of any response. Whereas the durability of mAb function is dictated by standard pharmacokinetics, the durability of CAR-T responses may be longer if they function as an immunomodulatory reset to the immune system. Time and data will tell. #Alloplex #celltherapies #CAR-T #oncologyresearch #cancerresearch

Currently, there is no test system, whether in vitro or in vivo, capable of examining all endpoints required for #genotoxicity evaluation used in pre-clinical drug safety assessment. The objective of this study was to develop a model which could assess all the required endpoints and possesses robust human #metabolic activity, that could be used in a streamlined, animal-free manner. Liver-on-chip (LOC) models have intrinsic human metabolic activity that mimics the in vivo environment, making it a preferred test system. For this #assay, the LOC was assembled using primary human hepatocytes or #HepaRG cells, in a MPS-T12 plate, maintained under #microfluidic flow conditions using the PhysioMimix® Microphysiological System (MPS), and co-cultured with human lymphoblastoid (TK6) cells in transwells. Read More: https://lnkd.in/gHtaakwi

Maximize your research outcomes with high-quality Human iPSC-derived hepatocytes, Hepatosight-S® from NEXEL! These highly pure and functional hepatocytes - ·      Recover quickly upon thawing to form a monolayer of polygonal shaped cells ·      Express typical hepatocyte markers like HNF4α, A1AT, ASGPR1 ·      Demonstrate high fidelity to primary hepatocytes when tested in hepatotoxic conditions Key features of Hepatosight-S® ·      Human Liver Functional Model ·      Accurate Human Toxicity ·      Long-term 3D Organoid Culture GV Research Platform (GVRP) is the authorized distributor of NEXEL's cell products and associated culture media in India. To learn more about NEXEL’s cell products, visit - https://gvrp.in/nexel/ Reach us for more information at: 📨: info@gvrp.in 🌐: www.gvrp.in ......................... #stemcelltechnology #drugdiscovery #toxicitytesting #hepatotoxicity #partnership #drugdevelopment #liverdisease #india #biomedicalresearch #stemcells #cellandgenetherapy

Preclinical findings indicate that blocking potassium channels in the upper airway with topical nasal application increases pharyngeal dilator muscle activity and reduces upper airway collapsibility. These findings highlight the potential for this novel therapeutic approach to improve #SleepApnea 😴https://ow.ly/oV3F50R3mQe

😃 Expanding the GPCR-RAMP Interactome with MolBoolean The GPCR-RAMP interactome is important for understanding G protein-coupled receptors (GPCRs) function, drug discovery, disease mechanisms, and personalized medicine. 👉🏼 In a new study, Kotliar et al, used the #MolBoolean assay from #AtlasAntibodies to test for native GPCR-RAMP complexes in cell membranes. They specifically investigated GPCR-RAMP2 interactions in SK-N-MC cells. The results of the MolBoolean assay showed that several GPCRs exhibited complex formation with RAMP2, such as the presence of GPCR-RAMP2 complexes in the cell membranes. Overall, the MolBoolean assay provided evidence for the physiological relevance of GPCR-RAMP interactions and confirmed the presence of GPCR-RAMP2 complexes in native cell membranes. 👉🏼 Read full article here: https://ow.ly/qgcf50SkNrH 👉🏼 Learn more about MolBoolean: https://lnkd.in/dAFePfmk #insituPLA #antibodies #proteomic #GPCRs