Tom Jones’ Post

Available in the BNLX and Nordics via BIOKÉ! BioSkryb Genomics has announced the launch of its groundbreaking ResolveDNA Whole Genome and ResolveOME Whole Genome and Transcriptome Single-Cell Core Kits, marking a significant leap forward in single-cell multiomics research. These cutting-edge kits harness the power of primary template-directed amplification, delivering not only efficient workflows but also industry-leading insights into single-cell DNA. With streamlined processes taking less than eight hours, researchers can now delve into the intricate details of clonal architectures and gain invaluable insights into disease pathogenesis using longitudinal samples. What's more, the ResolveOME kit goes beyond conventional approaches by seamlessly integrating DNA and RNA from every cell, eliminating the need for cumbersome sample splitting. This integration not only simplifies the workflow but also ensures comprehensive multiomic analysis, providing researchers with a holistic view of cellular processes. Powered by BioSkryb's innovative BaseJumper platform, comprehensive data analysis and visualization are now at researchers' fingertips. Additionally, ResolveServices™ offers tailored solutions such as the ResolveXOME exome enrichment solution and custom DNA panels, enabling researchers to customize their genomic analyses to suit their specific research objectives. With BioSkryb's cutting-edge technologies and customizable solutions, researchers can now unlock the full potential of single-cell multiomics with unprecedented ease and precision. #genomics #singlecell #multiomics #dnaanalysis #research #biotech

🔬 New Technology for Spatial Genomics! 🧬 Check out the recent study "Slide-tags enables single-nucleus barcoding for multimodal spatial genomics" published in Nature by Andrew J. C. Russell et al. 🚀 Slide-tags allows tagging single nuclei within intact tissue sections using spatial barcode oligonucleotides from DNA-barcoded beads with less than 10 μm spatial resolution and high-quality whole-transcriptome data. 🧫📊 🔵 Adaptable to various single-cell measurement technologies, including multiomic measurements of open chromatin, RNA, and TCR sequences. 🟠 Successfully used in the human cortex to uncover cell-type-specific spatial gene expression patterns and identify spatially varying genes systematically. 🟣 Analyzed densely packed tissues like the human tonsil, identifying subpopulations and spatially varying genes in germinal center B cells, T follicular helper cells, and follicular dendritic cells. 🟢 Achieved higher spatial resolution and molecular sensitivity compared to existing approaches. 📚 Nature paper: https://buff.ly/3RnwqUR 📢 Join the Conversation 📢 Share your ideas, methods, and tools in the comments! 👇 💬 #Genomics #SpatialGenomics #SingleCell #Bioinformatics #Pharma #ResearchInnovation #Biotechnology #LifeSciences #NatureResearch

BioSkryb Genomics is proud to announce our new ResolveDNA® Whole Genome Single-Cell Core Kit is now shipping. The ResolveDNA Core Kit combines the power of primary template-directed amplification (PTA) with library preparation and adapter ligation to provide a convenient, scalable, and streamlined workflow, while maintaining industry-leading whole genome amplification. Additional details on this new product, including performance specifications, can be found in the product brochure: https://lnkd.in/ePiJPb4R ResolveDNA can help you: • Capture 97% of the genome • Analyze co-occurring SNVs, CNVs, and SVs • Resolve clonal architecture with unprecedented resolution Learn more: https://lnkd.in/dwUxZqV5 #genomics #multiomics #singlecell

Twist Bioscience, a pioneer in providing high-quality synthetic DNA through its innovative silicon platform, has announced the introduction of the Human Pangenome Spike-in for the Twist Exome 2.0 panel. This development aims to empower researchers by enabling them to detect a broader spectrum of genetic variation during whole exome sequencing (WES). Emily Leproust, Ph.D., CEO, and co-founder of Twist Bioscience emphasized the importance of inclusive research tools, stating, "No single human genome can fully represent the diversity of our population. To drive scientific progress for all communities, researchers require tools that cater to diverse backgrounds." By harnessing the reference sequences curated by the Human Pangenome Reference Consortium (HPRC), Twist Bioscience offers a solution that facilitates a deeper understanding of human genetic diversity, essential for the development of new assays. The Human Pangenome Reference Consortium (HPRC), funded by the National Human Genome Research Institute (NHGRI), is dedicated to sequencing and assembling complete genomes from individuals representing diverse populations. This effort aims to create a more comprehensive reference standard, reflecting the genomic landscape of various human populations. Notably, the updated HPRC reference includes samples from individuals with African, Americas, East Asian, and South Asian ancestry. Bob Fulton and Karen Miga, Co-Chairs of the Production and Technology Working Group of the Human Pangenome Reference Project, highlighted the significance of collaboration with companies like Twist. They noted that utilizing the HPRC reference standard in research tools supports scientists in studying genetic variation, potentially leading to the development of more effective diagnostic tests and treatments tailored to diverse genomic data. #geneticresearch #diversity #twistbioscience #pangenome #exomepanel

🚀 Exciting Advances in Genetic Engineering! 🚀 Thrilled to share a groundbreaking development in genomic rearrangements. Latest research unveils the potential of IS110 insertion sequences, a family of minimal and autonomous mobile genetic elements, in genome design. These elements express a structured non-coding RNA that binds specifically to their encoded recombinase, enabling sequence-specific recombination between two DNA molecules. Key Highlights: 🔬 Structured Non-Coding RNA: Binds to the IS110-encoded recombinase, facilitating precise genomic rearrangements. 🧬 Modular and Programmable: The target-binding and donor-binding loops can be independently reprogrammed for directed DNA insertion, excision, and inversion. 🌟 Unified Mechanism: Offers a versatile tool for genome design, expanding the diversity of nucleic-acid-guided systems beyond CRISPR and RNA interference. This innovative IS110 bridge recombination system paves the way for advanced genome engineering, providing new opportunities for genetic research and applications. #GeneticEngineering #GenomeDesign# #Biotechnology #ResearchInnovation#

🔬 Advancing Target Enrichment for Precision Genomics.🔬 In the area of genomic analysis, precision is paramount. Our team has pioneered a transformative approach to target enrichment, seamlessly integrating it into the standard sequencing workflow on the Element AVITI™ System. Key Points: 🎯 Hybridization-based methods have revolutionized genomic region enrichment over the past 15 years. 🎯 From disease variant discovery to somatic applications, targeted enrichment offers sensitive and efficient sequencing solutions. 🎯 We recognize the need for enhanced sensitivity in challenging genome regions and for detecting low-frequency variants, particularly in somatic analyses. Our Solution: ✨ Integrated, on-flow cell target enrichment on the Element AVITI System. ✨ Unique surface chemistry eliminates additional time and steps in sequencing. ✨ No modifications needed in library preparation; one workflow fits various target enrichment experiments. Ready to Shift Your Science? Dive into our scientific poster for insights into efficient target enrichment in oncology and exome studies: https://bit.ly/3xNtpqO #ElemBio #AVITI #PrecisionGenomics #Sequencing #TargetEnrichment #GenomicAnalysis #ResearchInnovation #ShiftYourScience

Attention genomics researchers and lab managers! 🧬🔬 It's time to check out our latest guide: "Automated liquid handling miniaturization for genomics applications". Read the guide to learn more around: - Key automation and miniaturization considerations - The benefits miniaturization can bring to NGS library preparation workflows - The advantages automation can bring to your genomics application Whether you're working on NGS library prep, PCR setup, or high-throughput screening, this guide is your key to unlocking the power of miniaturization! 👉 Download now: https://lnkd.in/ghVQ8QqY #Genomics #LabAutomation #LiquidHandling #ScienceTech SelectScience

🎉 Announcing the launch of our FlexPrepUltra-High Throughput Library Preparation Kit! Designed with a proprietary Twist-developed enzyme to enable throughput at low cost, and accelerate the adoption of NGS by microarray users in population and agrigenomics, complete with Gencove software for genomic analysis. “At Twist, we continue to push the boundaries of what applications can be made possible with synthetic DNA and to develop products that open up new markets. Legacy methods of profiling very large numbers of samples for agrigenomics to genotype cows, pigs and other animals as well as for population genomics studies, have not kept pace with evolving NGS methods and are tied to a fixed set of markers. Innovative next-generation sequencing methods provide far superior data to microarray technology, with the Twist FlexPrep UHT Kit surpassing even the most advanced NGS methods to maximize throughput and minimize cost,” said Emily Leproust, Ph.D., CEO and co-founder of Twist Bioscience. “When conducting large scale experiments and running multiple samples in parallel, researchers must ensure that there is equivalent mass of each sample included, and this ‘normalization’ process takes time, energy and effort. Using a novel technology, the FlexPrep UHT Kit self-normalizes, eliminating a critical time-consuming step while at the same time enabling high throughput, streamlining workflows and enabling scalability and customization. In addition to the differentiating capabilities of the kit, we’re collaborating with Gencove to offer a complementary genomic analysis solution to our customers.” Learn more here: https://lnkd.in/gvTTt6ws Find FlexPrep here: https://lnkd.in/g_PdhhHu Twist Bioscience, #DNA #NGS

𝐓𝐡𝐞 𝐞𝐯𝐨𝐥𝐮𝐭𝐢𝐨𝐧 𝐨𝐟 𝐡𝐮𝐦𝐚𝐧 𝐠𝐞𝐧𝐨𝐦𝐞 𝐬𝐞𝐪𝐮𝐞𝐧𝐜𝐢𝐧𝐠 - 25 𝐲𝐞𝐚𝐫𝐬 𝐚𝐠𝐨 𝐭𝐨 𝐭𝐨𝐝𝐚𝐲 From the sequencing of chromosome 22 in 1999 to today's rapid and cost-effective next-generation sequencing (NGS), the world of genomics has changed dramatically. In our latest blog, we explore this fascinating journey and highlight the incredible advances in DNA sequencing technology over the past 25 years and its profound impact on medicine and biological science. At Micronit, we are proud to have been part of this journey of discovery since our founding 25 years ago in 1999. Our innovative glass microfluidic chips play an important role in enabling the precision and efficiency needed for modern genomic research. Find out how sequencing has shaped the future of personalized medicine, targeted therapies and more. 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗳𝘂𝗹𝗹 𝗯𝗹𝗼𝗴 𝗵𝗲𝗿𝗲: https://lnkd.in/eZ7qGZWt #Genomics #DNASequencing #NextGenSequencing #PersonalizedMedicine #Micronit #Microfluidics #Biotechnology #Innovation

Are you ready to dive into the latest breakthroughs in genomics? The American Society of Human Genetics (ASHG) Annual Meeting 2024 is just around the corner! As a scientist or biotech professional, staying current with rapidly evolving genomic technologies and research can be overwhelming. How do you separate the signal from the noise? The ASHG 2024 conference in Denver, CO, offers a solution by bringing together leading experts, cutting-edge research, and networking opportunities all in one place. From genome sequencing to precision medicine, this event covers it all. By attending, you'll gain invaluable insights into the latest advancements in human genetics, potentially accelerating your research or product development. Don't miss the chance to hear from renowned speakers like David Altshuler of Vertex Pharmaceuticals and Heather Hampel from City of Hope National Medical Center. Want to learn more about ASHG or to schedule time to meet with us at the event? Head to the blog: https://hubs.li/Q02VL0sJ0 #GenomicsResearch #BiotechInnovation #ASHGConference #LifeSciences #ASHG2024 #BiotechConference #LifeScienceMarketing #LeadGeneration