University of Arizona BIO5 Institute’s Post

“Understanding the metastatic tumor landscape is greatly helped by having access to the resource Hartwig Medical Foundation provides. Earlier large-scale initiatives, such as TCGA, focused on primary cancer instead. Hartwig provides the cancer research community with valuable oncogenomic resources for thousands of metastatic cancer patients”: Lodewyk Wessels, Group leader Computational Cancer Biology The Netherlands Cancer Institute. Daniel Vis, Postdoctoral Research Fellow, Soufiane Mourragui, Computational Biologist Hubrecht Institute, Developmental Biology and Stem Cell Research, Jinhyuk Bhin  Would you like to use this data, too? https://lnkd.in/excwE-kp  The data is pseudonymized and made available free of charge to cancer research institutes and hospitals. It is used by research groups all over the world. Hartwig Medical Foundation is a not-for-profit organization that promotes scientific research in the fight against and treatment of cancer and other diseases, in the broadest sense and provided it is in the public interest.   #cancerresearch #cancergenomics #bioinformatics 

Congratulations to Irene Ghobrial, MD, Dr. med. David Cordas dos Santos, and the Ghobrial Lab at Dana-Farber Cancer Institute for being awarded a prestigious grant from the NIH/NCI as part of the Human Tumor Atlas Network. This funding will support the lab's groundbreaking work on the Multidimensional Myeloma Pre-Cancer Atlas (MMPCA), which aims to create a comprehensive spatial and temporal map of disease progression in multiple myeloma. The MMPCA will analyze genomic and microenvironmental changes, using state-of-the-art techniques like spatial transcriptomics, proteomics, and single-cell sequencing. This research will deepen our understanding of how precursor conditions evolve into overt myeloma, paving the way for more effective treatments and earlier interventions. https://lnkd.in/eArBbb85

Reveal more about the underlying mechanisms of #cancer. Join us at #AACR24 to hear how researchers are generating ultra-rich #nanopore data — resolving SNPs, SVs & epigenetic mods, at the haplotype level from a single dataset — to gain an unprecedented view of cancer. During our Spotlight Theater session Mikhail Kolmogorov, Ayse Keskus and Julie Geyer will discuss accelerating precision oncology research with nanopore sequencing. There's also plenty going on on our booth... Don't miss our live sequencing demos. Learn how to use adaptive sampling to enrich any #cancer gene panel of interest, and how to characterise genomic and epigenomic variation between tumour-normal samples using long, native #nanopore sequencing reads. Grab a coffee and join us at one of our three Data for Breakfast sessions. Learn how you can generate ultra-rich nanopore sequencing to gain an unprecedented view of cancer. #WYMM #AACR Learn more: https://bit.ly/3wZtPtJ

Following up on my previous post about my journey into the fascinating world of genomics, I’ve come to realize the importance of a hook—something that captivates your interest and keeps you engaged. This concept was familiar to me from homeschooling my children, where I emphasized the importance of a compelling start in storytelling. It turns out, the same principle applies to podcasts. I recently experienced this firsthand while listening to a conversation between Cara and Erica, which concluded with an intriguing question: "If given a magic wand, what would you wish for?" The answer—molecular tumor boards for every patient—struck a chord with me and brought back memories of my time at VCU (Virginia Commonwealth University) in the Radiation Oncology department. I vividly recall attending tumor board meetings where critical patient cases were discussed by a multidisciplinary team, including medical, radiation, and surgical oncologists. At the time, much of the conversation went over my head, but I now see how crucial these interdisciplinary discussions are for devising the best treatment strategies. Cancer is inherently an interdisciplinary disease, requiring the collaboration of various specialists to navigate a patient's journey toward the best possible prognosis. In today’s era, molecular tumor specialists play a vital role in helping physicians leverage biomarker and genomic information to enhance patient care. A wise colleague once told me, “You can’t call yourself an oncology domain expert without delving deep into genomics.” With that in mind, my quest to deepen my understanding of genomics continues, fueled by podcasts and other educational resources. #Cancer #Oncology #Interdisciplinary #Genomics

Proud to work with an organization that is supporting projects that have real impact on cancer patients. As a scientist, and as a breast cancer patient, I would like to celebrate the amazing role #genomics is playing in the diagnosis and treatment of patients with #cancer. #CancerAwarness #April #Genome #GenomicProfiling #PrecisionOncology #GenomicsForAll #BigData #DataSharing

Unravel cancer cell evolution with BioSkryb at the American Association for Cancer Research® (AACR) Annual Meeting 2024 in San Diego. The all-new ResolveDNA® and ResolveOME™ single-cell core kits enable multiomic characterization of DNA and RNA from each cell in order to unravel the complexity of tumor biology. Compatible with automation and optimized for scale, these kits provide a complete end-to-end workflow that produces sequencing-ready libraries in under 8 hours. Visit Booth #704 at #AACR24 to see how the new core kits for ResolveDNA enable detection of co-occurring SNV, CNV, ploidy, and structural variants from each cell, and how ResolveOME core kits layers-in the full-length transcriptome data from each genotyped cell. Learn more, or schedule a meeting: https://lnkd.in/eFd8U2DE #singlecell #research #genomics #cancerresearch #singlecell #multiomics #AACR24

This is how you use Phenoplex to get the most out of the software. Also, spatial biology is happening everywhere - not just where you think to look! Watch this and learn what I mean.

🔬It's Fluorescence Friday and today we are very excited to feature a recent publication in the journal Molecular Cancer by the group of Prof. Wayne A. Marasco from Dana-Farber Cancer Institute Inc. The research, led by Dr. Yufei (Sophie) Wang, addressed a fundamental problem in the revolutionary immunotherapy approach CAR-T: Most solid tumors don't have proteins that are exclusively expressed in their cells and not in healthy cell, but instead, tumor cells express the same proteins as healthy cells, only in different numbers, a phenomenon that is known as of on-target off-tumor (OTOT). The research group set up to engineer new CAR-T cells that exclusively target kidney cancer cells that express many copies of the protein CAIX but not healthy bile duct cells that express only few copies of this protein. For that, they joined forces with ONI's experts, András Miklósi, Haraman Johal and Ricardo Nunes Bastos, and together they harnessed the power of the #Nanoimager and #dSTORM imaging to define exactly how many single protein molecules of the protein CAIX are present on tumor samples from patients, on healthy bile duct cells and on cultured cells they used as a model. The difference in the numbers of single protein molecules was enough to screen new CAR-T cells that could have fewer side effects in kidney cancer patients. ONI is extremely proud to take part in such an important research, and to have our technology used to improve people's health and make their lives better. We offer our congratulations to Prof. Marasco and to the whole team, and we are excited to see where their research takes them next! Read their paper at: https://hubs.li/Q02qjVq60 #fluorescenceFriday #cancerResearch #CarT #microscopy #superresolution #biology #research #imaging #kidneycancer #caix

The podcast I recently posted was a follow-up to my paper that was published in conjunction with the Ipsos Global Oncology Centre of Expertise back in November 2023. This POV, Mastering Complexity, can be found here (along with the podcast): https://lnkd.in/ggvaV_hh 🚀 This paper is the grand finale of an epic eight-year journey, a series that set out to challenge and decode the enigma of cancer. 🌌 We venture into uncharted territories of cancer treatment, wielding revolutionary tools such as third-generation sequencing, labs on a chip, artificial intelligence, and nanorobots. 🔮 We unveil the extraordinary realm of cancer's complexity, like a cosmic explorer discovering galaxies of mind-boggling numbers and intricate genetic pathways. 🐘 Highlighting nature's ingenious survivors like elephants and mole rats, we unravel their secret shields against cancer, a testament to evolution's miraculous solutions. 💫 We dare to dream of a future where cancer is but a memory, a world where we have harnessed our human complexity and emerged victorious. 🔗 If you haven't read the paper already, the Ipsos Oncology CoE invites you on this thrilling journey, to explore the frontiers of cancer research. Join the conversation, share your insights, and let's shape the future of cancer treatment together... #CancerResearch #Genomics #ArtificialIntelligence #MolecularDiagnostics #PrecisionMedicine #GeneticEngineering #Oncology

👨🔬 Meet Matteo - senior scientist in the Cell Stress and Survival group 💫 Matteo was born in Italy 🇮🇹 and is now working at the Danish Cancer Institute 💚 where he, along with 200 colleagues from 27 countries, work tirelessly to find new answers to the many questions about cancer ⭐ Find out more about Matteo and his research here👇 ❇️ My research: 💬 I have extensive knowledge in cell and molecular biology, specialising in mitochondrial homeostasis and cellular metabolism and signaling. My research focuses particularly on investigating the mechanisms that cells use to detect and break down damaged or unnecessary mitochondria. ❇️ I work at the Danish Cancer Institute because: 💬 I believe that the DCI provides a stimulating research environment. My goal in working here is to apply my knowledge to research the mechanisms behind tumor development and how cancer cells, by altering their metabolism, can become resistant to treatment. ❇️ One of my most significant findings is: 💬 I have discovered a new molecular process that exists across two separate organelles: lysosomes and mitochondria. Currently, I am investigating how cancer cells can use this mechanism to enhance their own survival. #cancerresearch #cancer #research #science #biology