UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences’ Post

Tryptophan’s dark journey: how the Kynurenine pathway fuels HIV’s hidden dangers. Uncover the secrets to fight a "metabolic war" against HIV. It's easy to understand on the graphic how the Kynurenine pathway can cause HIV-Associated Mitochondrial Dysfunction (HIVAMD) and accelerated aging on PLWH on ART. There is something wrong with the Quinolinate Phosphyribosyl Transferase (QPRT) enzyme on PLWH otherwise most of the Quinolinic acid would transform to NAD(+) ("De-novo" pathway). I think chronic inflammatory states like HIV lean the pathway toward 3HK, 3HAA, and Quinolinic acid formation with LESS NAD(+) production. Like an intracellular pellagra state?. I think that potentially we can manipulate this.... Figures subject to copyright

This webinar by CORE - Community Response to Reduce Inequalities, includes recommendations by the WHO to modernise testing algorithms to expand screening and for prompt linkage to care, and addresses Western Blot testing in the context of other effective and cheaper options to confirm an HIV diagnosis. WHO provides an overview on the diagnostics landscape for cost-effective testing in community settings. Participants will discuss ways in which to increase testing capacity of service providers.  The needs assessment, conducted among CORE’s 14 community-based organisations across 12 European countries, revealed that testing kits used could be more cost-effective to save resources and scale up testing. Speakers: Cheryl Johnson – WHO Headquarters, Geneva and Viatcheslav Grankov – WHO European Region Office, Copenhagen.  https://lnkd.in/grestuRe

"HIV viral load refers to the amount of HIV RNA present in the blood and serves as a critical indicator of HIV replication in the body. Monitoring viral load levels is essential for assessing the effectiveness of treatment, reducing the risk of disease progression, and preventing transmission of HIV to others." For Details and Appointment +91- 9136363692 , +91- 9871605858 www.hivdoctorsindelhi.com https://lnkd.in/dyE3aVEx #HIVprevention #PEPtreatment #healthcare #stopHIVtransmission #knowyourstatus #gettested #healthylifestyle #preventioniskey #spreadawareness #endHIVstigma #Drvinodraina #drrainasafehandsclinic #needleprickinjury #hivtreatmentindelhi #pepforhivtreatment #HIVTesting #hivaids #needle #hivawarenessandprevention #pepmedication #health #doctor #prptreatment #exposure #PEPTreatment #postexposureprophylaxis

From my previous role: Our team of collaborators published this paper studying how well different lentiviruses related to HIV replicate in lymphoid tissues. https://lnkd.in/gpwcz9rM

Implementation of a rapid diagnostic assay package for cryptococcosis, histoplasmosis and tuberculosis in people living with HIV in Paraguay https://lnkd.in/ewA4SbxU

⭐ Let's Unite for STI Awareness Week! ⭐ Today miDiagnostics wants to repeat Dr. Teodora Wi, Lead for Sexually transmitted infections of the WHO Global HIV, Hepatitis and STIs Programmes message: “Early testing and diagnosis are key in stopping the spread of STIs. When left untreated, certain STIs can lead to long-term irreversible outcomes and some can be potentially fatal." Let's spread the message together 🤲 #STIawarenessweek #earlydetection #miDX #togetherwecare

Recurrent pneumonia is defined by two or more episodes within a 1-yr period and should be considered an AIDS￾defining condition. HIV testing should be pursued if the status is unknown (ATS 2023). #RespiratoryMedicine #RespiratoryICU #ICHP

Nelson Vergel, an HIV long-term survivor and friend of RORA Bio recently chronicled his journey as person living as an HIV-immune non-responder (“HIV-INR”). See the link below. People living as HIV-INRs face persistent immunological challenges in which their CD4 T-cell levels remain below 300 cells/mL (a better range is 500-1500). The low T-cell level makes them more susceptible to infection and certain cancers for life. RORA Bio is developing a first-in-class T-cell platform that may help support T-cell levels in HIV-INR patients should future clinical trials be successful. The platform consists of a newly discovered, long-lived, stem-like memory cell population that we call “RORA cells”. https://lnkd.in/eRRenhrY

The PURPOSE 1 trial demonstrated that after 52 weeks, no cisgender women acquired HIV infection after receiving subcutaneous twice-yearly lenacapavir. Read Viewpoint in Med by Cell Press https://lnkd.in/gpqSsvHy HIV incidence with lenacapavir was significantly lower than HIV incidence with daily oral emtricitabine/tenofovir alafenamide (F/TAF) or daily oral emtricitabine/tenofovir disoproxil fumarate (F/TDF). It is the first pre-exposure prophylaxis regimen with 100% efficacy in young women. #HIVPrevention #Lenacapavir #PURPOSE1Trial 

Congratulations to all coauthors and to all who helped in the implementation of this important project! Our article “The Effect of a Tobacco Use Reduction Program on the Prevalence of Smoking and Tobacco Use and Quitting Behavior Among People Living With HIV/AIDS in Michigan" has published in the peer reviewed Journal, Preventing Chronic Disease in January 2024. Here is the citation for the article: Shamo F, Macomber KE, Hitchingham J, Bennett S, Watson S. The Effect of a Tobacco Use Reduction Program on the Prevalence of Smoking and Tobacco Use and Quitting Behavior Among People Living With HIV/AIDS in Michigan. Prev Chronic Dis 2024;21:E03. [PMID: 38207177 DOI: 10.5888/pcd21.230115]