UD Office of Economic Innovation and Partnerships’ Post

#HighlyCitedPapers 📝 Recent Advances in Biocatalysis for Drug Synthesis — Kinner et al. In this paper, the authors aim to highlight recent developments in biocatalysis, particularly focusing on their relevance for synthesizing and late-stage functionalization of active pharmaceutical ingredients, thereby bypassing traditional chemical processes. Full text is available 👇 https://lnkd.in/d_sMEDxY #medicine #health #research #science

The Polymer Science & Technology Congress starts today, come by and take a look at Dr. Marjan Hezarkhani's poster on “Antifungal and antibacterial activity of a novel pullulan-graft-Poly N-vinyl imidazole". We are proud to see one of our experts in Pharmaceutical Development driving important research in this critical scientific field. Learn more at Polimertr.org #SGSUK #Pharma #LifeSciences #Research #Polymer #Antifungal #Antibacterial

📖📖📖Highly-Cited Paper #article #recommendation Comprehensive Characterization of 76 Pharmaceuticals and Metabolites in Wastewater by LC-MS/MS by Cristian Gómez Canela, Sílvia Edo, Natalia Rodríguez, Gemma GOTOR NAVARRA, and Silvia Lacorte. 👉https://lnkd.in/eM-gjDhz MDPI, Institut Quimic de Sarria Cets, Universitat Ramon Llull, Institute of Environmental Assessment and Water Research (IDAEA-CSIC) #pharmaceuticals #metabolites #wastewater #lcms #ms #analysis #chemistry This article belongs to the Collection Recent Trend in Chromatography for Pharmaceutical Analysis: https://lnkd.in/d-X-ABKW

Chemists from MIT have developed a novel system to synthesize complex molecules known as oligocyclotryptamines. Oligocyclotryptamines are complex compounds originally isolated from plants that demonstrate potential for use in an array of pharmaceutical products including antibiotics, analgesics, or cancer drugs. While promising, only small quantities of oligocyclotryptamines are naturally available. To overcome this lack of availability, MIT chemists developed a method, published in the Journal of the American Chemical Society, to add tryptamine-derived components one at a time to molecules. This approach allows the team to precisely assemble the rinds and control the orientation of the final product. #PharmaceuticalInnovation #DrugDiscovery #Chemistry #MIT #PharmaceuticalResearch #HealthcareInnovation #MedicinalChemistry #SynthesisMethod #LifeSciences #HealthcareTechnology #ResearchAndDevelopment #Biotech #HealthcareScience #InnovationInScience #PharmaTech

New paper alert! Matteo Salvalaglio is a leader in the implementation of molecular dynamics in #crystallization (among other things!), and I have been fortunate enough to #collaborate with him for several years on a number of projects. In this paper, we integrated experimentation and modelling to rationalise the impact of #impurities on the crystallization of an active pharmaceutical ingredient. Hope you enjoy the read, and feel free to send comments, questions, feedback and share instances where you observed similar effects. ------------------------------------------------------------------------------- We are Particology Ltd, your friendly particle experts. Reach out to find out more about us: team@particology.com, or check us out on: https://lnkd.in/dMfSD6n3 #particology #solidform #polymorphism #particleengineering #crystallization #particlecharacterization #formulation #pharmadevelopment #contractresearch

𝐇𝐢𝐠𝐡-𝐩𝐞𝐫𝐟𝐨𝐫𝐦𝐚𝐧𝐜𝐞 𝐋𝐢𝐪𝐮𝐢𝐝 𝐂𝐡𝐫𝐨𝐦𝐚𝐭𝐨𝐠𝐫𝐚𝐩𝐡𝐲 (𝐇𝐏𝐋𝐂) 𝐌𝐚𝐫𝐤𝐞𝐭 𝐰𝐨𝐫𝐭𝐡 $5.7 𝐛𝐢𝐥𝐥𝐢𝐨𝐧 Download PDF Brochure Now: https://lnkd.in/djtUANns The growth in this market is driven by high sensitivity &accuracy of the HPLC technique, the growing importance of HPLC tests in drug approvals, the rising popularity of hyphenated techniques, and increasing pharmaceutical R&D spending. However, the high cost of HPLC systems is expected to restrict market growth to a certain extent. 𝐓𝐡𝐞 𝐜𝐨𝐦𝐩𝐚𝐧𝐢𝐞𝐬 𝐟𝐞𝐚𝐭𝐮𝐫𝐞𝐝 𝐢𝐧 𝐭𝐡𝐢𝐬 𝐫𝐞𝐩𝐨𝐫𝐭 𝐢𝐧𝐜𝐥𝐮𝐝𝐞: Waters Corporation  Agilent Technologies  SHIMADZU CORPORATION  Thermo Fisher Scientific PerkinElmer  GE HealthCare  Bio-Rad Laboratories Merck Millipore Hitachi Showa Denko Carbon, Inc. Phenomenex Jasco Hamilton Company SIELC Technologies orochemie GmbH + Co. KG Restek Corporation Trajan Scientific and Medical Tosoh Bioscience, Inc. #chromatography #healthcare #biotechnology #pharmaceuticals

Peptide drugs, biological fermentation, Pharmaceuticals applications and natural products can be separated and purified, with target compounds extracted and high-purity substances recovered, using sample sizes ranging from milligrams to grams. ASA LC-2000 is ideal for purification units in universities, pharmaceutical factories, and research institutions, CRO's enabling structural identification, small-scale preparation, and process research and development. # Purifications # Chromatography # Semi-Preparative HPLC # Peptide

🌟 We are excited to announce a new collaboration between leading small molecule API CMO ESTEVE QUIMICA, INSTITUT DE CIÈNCIA DE MATERIALS DE BARCELONA (ICMAB-CSIC) research center and NANOMOL TECHNOLOGIES, experts in particle engineering and characterization. Over the next three years, we aim to develop scalable, efficient, and sustainable techniques for producing drug intermediates with enhanced solubility, bioavailability and controlled solid form. 🔬 Drug development is costly and risky. To address these challenges and boost value, the PHASOL project, funded by the Agencia Estatal de Investigación, focuses on complementary particle technologies such as compressed fluid precipitation and spray drying to optimize the administration of active ingredients. This approach aims to seek synergies between the 3 participating entities, and to create solutions for development and manufacturing of pharmaceutical intermediates with significant improvements in quality, efficacy, and safety. 🚀 Stay tuned as we revolutionize the pharmaceutical industry! #Pharmaceuticals #Innovation #Collaboration #DrugDevelopment #Bioavailability #Sustainability #SprayDrying #CompressedFluids

Late Stage Saturation (LSS) vs Late Stage Functionalization (LSF) Converting aromatic molecules into saturated analogs with a higher fraction of sp3 carbons holds promise for enhancing their medicinal properties. This study demonstrates the feasibility of saturating aromatic and heteroaromatic drugs through mild rhodium-catalyzed hydrogenation, acid-mediated reduction, or photocatalyzed-hydrogenation techniques. By transforming sp2 carbon atoms into sp3 carbon atoms, can create saturated molecules with improved medicinal characteristics. Notably, the rhodium-catalyzed approach accommodates traces of dimethyl sulfoxide (DMSO) or water, enabling the reformulation of pharmaceutical compound collections stored in wet DMSO for chemical synthesis. Exemplified through the late-stage saturation (LSS) of 768 complex and densely functionalized small-molecule drugs, showcasing the transformative potential of these techniques in drug development. Great work Dr. Frank Glorius Dr. Tim Cernak and the team. #SaturatedMedicines #FunctionalizationVersusSaturation #RhodiumCatalyzedChemistry #DrugDevelopmentMethods #LateStageTransformation #MedicinalChemistry #PharmaceuticalInnovation #Sp3CarbonConversion #TransformativeDrugResearch #ChemicalSynthesisTechniques #NCATS #NIH #JACS

Dr. Shaukat Ali, senior director of scientific affairs and technical marketing at Ascendia, and Dr. John Carpenter, professor emeritus of pharmaceutical sciences at the University of Colorado, recently conducted a webinar on lyophilized formulations of #biological molecules (eg, proteins). The presentation examined the main steps in the #lyophilization process and the mechanisms by which excipients provide stabilization to protein during freezing, drying, storage, and reconstitution. Watch the webinar here: https://lnkd.in/eGdpu5kE #DrugDevelopment #CDMO