FUJIFILM Wako Chemicals USA’s Post

#Neuroscience research has traditionally relied on primary neuronal cell cultures, which can be limited and challenging to work with. This is particularly critical in drug discovery for neurodegenerative diseases, where robust and scalable models are essential. Stem cell-derived neurons, particularly human iCell® Neurons, offer a scalable solution, addressing the limitations of primary cell cultures. These neurons provide a physiologically relevant environment for studying human drug targets in terminally differentiated, postmitotic cells. At Nanion Technologies, in collaboration with FUJIFILM Cellular Dynamics, Inc, we have prepared an 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗡𝗼𝘁𝗲 that may interest researchers working in neuroscience drug discovery. Here are a few highlights from this AppNote: ◾ Human iPSC-derived neurons, such as iCell® Neurons, offer a scalable, flexible, and cost-effective solution for neuroscience research. ◾ These neurons were successfully utilized on the Patchliner, facilitating detailed electrophysiological studies. The Patchliner’s capabilities allowed for simultaneous recording from multiple cells, providing robust data. ◾ iCell® Neurons express key ion channels, including NaV, KV, and GABAA receptors, and demonstrate electrophysiological properties aligning closely with those observed in manual patch clamp studies, providing reliable data for neurotoxicity, disease research, and drug discovery. ➡ For full details, 𝗱𝗼𝘄𝗻𝗹𝗼𝗮𝗱 𝗼𝘂𝗿 𝗮𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗻𝗼𝘁𝗲 here: https://lnkd.in/gAqK7PYq #Neuroscience #DrugDiscovery #hiPSC #IonChannels #iPSC #neurons #PatchClamp